CA2000937A1 - Preparation de 5'-phosphate de riboflavine (5'-fmn) et de son sel de sodium et de chlorure de l'ester de l'acide riboflavine-4',5'-cyclophosphorique - Google Patents

Preparation de 5'-phosphate de riboflavine (5'-fmn) et de son sel de sodium et de chlorure de l'ester de l'acide riboflavine-4',5'-cyclophosphorique

Info

Publication number: CA2000937A1
Authority: CA; Canada
Prior art keywords: riboflavin; phosphate; preparation; acid ester; sodium salt
Prior art date: 1988-10-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2000937A

Other languages

English (en)

Other versions

CA2000937C (fr

Inventor

Johannes Grimmer

Hans Kiefer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

BASF SE

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-19

Filing date

1989-10-18

Publication date

1990-04-19

1989-10-18 Application filed by Individual filed Critical Individual

1990-04-19 Publication of CA2000937A1 publication Critical patent/CA2000937A1/fr

1997-03-18 Application granted granted Critical

1997-03-18 Publication of CA2000937C publication Critical patent/CA2000937C/fr

2009-10-18 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000011768 flavin mononucleotide Substances 0.000 title abstract 5
239000004228 Riboflavin-5'-Phosphate Substances 0.000 title abstract 4
FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 title abstract 4
235000019231 riboflavin-5'-phosphate Nutrition 0.000 title abstract 4
159000000000 sodium salts Chemical class 0.000 title abstract 3
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 title 1
239000002253 acid Substances 0.000 title 1
150000002148 esters Chemical class 0.000 title 1
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 abstract 2
-1 alkali metal salt Chemical class 0.000 abstract 2
XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
239000000010 aprotic solvent Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
235000019192 riboflavin Nutrition 0.000 abstract 1
239000002151 riboflavin Substances 0.000 abstract 1
229960002477 riboflavin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nutrition Science (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA002000937A 1988-10-19 1989-10-18 Preparation de 5'-phosphate de riboflavine (5'-fmn) et de son sel de sodium et de chlorure de l'ester de l'acide riboflavine-4',5'-cyclophosphorique Expired - Fee Related CA2000937C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3835563A DE3835563A1 (de)	1988-10-19	1988-10-19	Riboflavin-4',5'-cyclo- phosphorsaeureesterchlorid, dessen herstellung und verwendung zur herstellung von riboflavin-5'-phosphat (5'-fmn) bzw. dessen natriumsalz
DEP3835563.9		1988-10-19

Publications (2)

Publication Number	Publication Date
CA2000937A1 true CA2000937A1 (fr)	1990-04-19
CA2000937C CA2000937C (fr)	1997-03-18

Family

ID=6365440

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002000937A Expired - Fee Related CA2000937C (fr)	1988-10-19	1989-10-18	Preparation de 5'-phosphate de riboflavine (5'-fmn) et de son sel de sodium et de chlorure de l'ester de l'acide riboflavine-4',5'-cyclophosphorique

Country Status (5)

Country	Link
US (1)	US5017700A (fr)
EP (1)	EP0364875B1 (fr)
JP (1)	JP2716546B2 (fr)
CA (1)	CA2000937C (fr)
DE (2)	DE3835563A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3930668A1 (de) *	1989-09-14	1991-03-28	Basf Ag	Verfahren zur herstellung von riboflavin-5'-phosphat(5'-fmn) bzw. dessen natriumsalz
JP3274225B2 (ja)	1992-06-03	2002-04-15	富士写真フイルム株式会社	アミノ酸誘導体及びその用途
ITTO20020622A1 (it)	2002-07-16	2004-01-16	Dayco Europe Srl	Gruppo integrato puleggia-smorzatore torsionale
EP1553099A4 (fr) *	2002-08-02	2006-06-28	Inst Radiation Med Amms Pla	Derive de riboflavine ainsi que sa fabrication et ses utilisations
CN102617643B (zh) *	2012-03-06	2013-04-10	黄金秀	一种核黄素磷酸钠化合物
CN103396452B (zh) *	2013-08-19	2015-09-30	周晓东	一种核黄素磷酸钠化合物及其组合物
CN106674225B (zh) *	2016-11-09	2019-04-02	珠海同源药业有限公司	一种核黄素磷酸钠化合物及其药物组合物
CN107286194A (zh) *	2017-06-07	2017-10-24	山西集翔生物工程有限公司	一种核黄素磷酸钠生产工艺
CN111094309A (zh) *	2018-09-21	2020-05-01	邦泰生物工程(深圳)有限公司	高纯度核黄素磷酸钠的制备方法
CN117257833A (zh) *	2023-08-17	2023-12-22	复旦大学附属眼耳鼻喉科医院	一种金属核黄素纳米材料及跨上皮角膜交联制剂
CN117442566A (zh) *	2023-09-25	2024-01-26	复旦大学附属眼耳鼻喉科医院	一种金属核黄素复合纳米材料的冻干制剂、分散方法及分散制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1684738A (en) *		1928-09-18		Charles henbi mabschalk
US2111491A (en) *	1935-01-26	1938-03-15	Winthrop Chem Co Inc	Process of preparing phosphoric acid esters of hydroxyalkyl isoalloxazines
US2661365A (en) *	1950-03-11	1953-12-01	Monsanto Chemicals	Alkanediol phosphoryl monochlorides
US2610177A (en) *	1950-11-08	1952-09-09	Hoffmann La Roche	Riboflavin monophosphoric acid ester salts and method of preparation
SU1007363A1 (ru) *	1981-05-08	1985-07-15	Ордена Трудового Красного Знамени Институт Органической И Физической Химии Им.А.Е.Арбузова	2-Замещенные 4-метилен-5,5-диалкил-1,3,2-диоксафосфоланы и способ их получени

1988
- 1988-10-19 DE DE3835563A patent/DE3835563A1/de not_active Withdrawn
1989
- 1989-09-28 US US07/413,590 patent/US5017700A/en not_active Expired - Fee Related
- 1989-10-12 DE DE8989118924T patent/DE58903876D1/de not_active Expired - Lifetime
- 1989-10-12 EP EP89118924A patent/EP0364875B1/fr not_active Expired - Lifetime
- 1989-10-18 CA CA002000937A patent/CA2000937C/fr not_active Expired - Fee Related
- 1989-10-18 JP JP1269248A patent/JP2716546B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3835563A1 (de)	1990-04-26
EP0364875B1 (fr)	1993-03-24
EP0364875A1 (fr)	1990-04-25
US5017700A (en)	1991-05-21
CA2000937C (fr)	1997-03-18
JP2716546B2 (ja)	1998-02-18
DE58903876D1 (de)	1993-04-29
JPH02174789A (ja)	1990-07-06

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Legal Events

Date	Code	Title	Description
1993-11-15	EEER	Examination request
2007-10-18	MKLA	Lapsed