CA2003190A1 - Composes pharmaceutiques contenant de l'acide n- (3,4,-dimetoxy-cinnamoyl) anthranilique - Google Patents

Composes pharmaceutiques contenant de l'acide n- (3,4,-dimetoxy-cinnamoyl) anthranilique

Info

Publication number: CA2003190A1
Authority: CA; Canada
Prior art keywords: dimethoxycinnamoyl; composition; anthranilic acid; pharmaceutical compositions; compositions containing
Prior art date: 1989-04-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2003190A

Other languages

English (en)

Other versions

CA2003190C (fr

Inventor

Tokihiko Yamamoto

Taihei Shibazaki

Yukihiko Kinoshita

Ryoji Yamamoto

Yukiyoshi Ajisawa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

NITTEN OPHTHALMIC RESEARCH Co

Kissei Pharmaceutical Co Ltd

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-04

Filing date

1989-11-17

Publication date

1990-10-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13861211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2003190(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-11-17 Application filed by Individual filed Critical Individual

1990-10-04 Publication of CA2003190A1 publication Critical patent/CA2003190A1/fr

1997-04-29 Application granted granted Critical

1997-04-29 Publication of CA2003190C publication Critical patent/CA2003190C/fr

2009-11-17 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

NZHGWWWHIYHZNX-UHFFFAOYSA-N 2-((3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid Chemical compound C1=C(OC)C(OC)=CC=C1C=CC(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-UHFFFAOYSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000000203 mixture Substances 0.000 abstract 3
206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
206010039085 Rhinitis allergic Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
201000010105 allergic rhinitis Diseases 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
150000007514 bases Chemical class 0.000 abstract 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Ophthalmology & Optometry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA002003190A 1989-04-04 1989-11-17 Composes pharmaceutiques contenant de l'acide n- (3,4,-dimetoxy-cinnamoyl) anthranilique Expired - Fee Related CA2003190C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP85521/01		1989-04-04
JP1085521A JPH07116029B2 (ja)	1989-04-04	1989-04-04	トラニラスト水溶液製剤

Publications (2)

Publication Number	Publication Date
CA2003190A1 true CA2003190A1 (fr)	1990-10-04
CA2003190C CA2003190C (fr)	1997-04-29

Family

ID=13861211

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002003190A Expired - Fee Related CA2003190C (fr)	1989-04-04	1989-11-17	Composes pharmaceutiques contenant de l'acide n- (3,4,-dimetoxy-cinnamoyl) anthranilique

Country Status (12)

Country	Link
US (1)	US5356620A (fr)
EP (1)	EP0391002B1 (fr)
JP (1)	JPH07116029B2 (fr)
KR (1)	KR940002660B1 (fr)
AT (1)	ATE103808T1 (fr)
AU (1)	AU623191B2 (fr)
CA (1)	CA2003190C (fr)
DE (1)	DE68914438T2 (fr)
DK (1)	DK555089A (fr)
ES (1)	ES2063146T3 (fr)
FI (1)	FI95773C (fr)
NO (1)	NO176346C (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5897858A (en)	1994-02-03	1999-04-27	Schering-Plough Healthcare Products, Inc.	Nasal spray compositions exhibiting increased retention in the nasal cavity
ATE222759T1 (de) *	1996-02-07	2002-09-15	Lead Chem Co Ltd	Tranilast enthaltendes externum und verfahren zu dessen herstellung
JPH09278653A (ja) *	1996-04-05	1997-10-28	Santen Pharmaceut Co Ltd	網膜疾患治療剤
IL118657A0 (en) *	1996-06-14	1996-10-16	Arad Dorit	Inhibitors for picornavirus proteases
ES2196366T3 (es) *	1996-09-28	2003-12-16	Kissei Pharmaceutical	Inhibidor de turbidez sub-epitelial.
EA001745B1 (ru) *	1996-10-14	2001-08-27	Киссеи Фармасьютикал Ко., Лтд.	Ингибитор вторичной катаракты
AU739271B2 (en) *	1997-02-14	2001-10-11	Kissei Pharmaceutical Co. Ltd.	Agents inhibiting progress of pterygium and postoperative recurrence of the same
EP1008347A4 (fr) *	1997-04-18	2002-02-06	Kissei Pharmaceutical	Remedes pour la prophylaxie ou le traitement de maladies se traduisant par une proliferation excessive des cellules epitheliales pigmentaires de la retine
IL122591A0 (en)	1997-12-14	1998-06-15	Arad Dorit	Pharmaceutical compositions comprising cystein protease inhibitors
US6274626B1 (en)	1998-12-22	2001-08-14	Bausch & Lomb Incorporated	Pheniramine-containing compositions and method for treating allergic responses
JP2001158750A (ja) *	1999-12-02	2001-06-12	Lion Corp	眼科用組成物及び抗アレルギー薬の持続性向上方法
JP4541504B2 (ja) *	2000-06-14	2010-09-08	沢井製薬株式会社	トラニラストまたはその薬理学的に許容される塩を有効成分として含有する安定な水溶液製剤
AU2002234236A1 (en) *	2001-01-10	2002-07-24	Smithkline Beecham Corporation	Process and product
JP2011225626A (ja) *	2001-02-01	2011-11-10	Rohto Pharmaceutical Co Ltd	点眼剤
JP2002363075A (ja) *	2001-06-05	2002-12-18	Kao Corp	高血圧症予防・治療剤
DE10254872A1 (de) *	2002-11-25	2004-06-03	Symrise Gmbh & Co. Kg	Anthranilsäureamide und deren Derivate als kosmetische und pharmazeutische Wirkstoffe
JP2004189731A (ja) *	2002-11-26	2004-07-08	Taisho Pharmaceut Co Ltd	点鼻剤
US20050106230A1 (en) *	2003-11-17	2005-05-19	Young Janel E.	Drug-enhanced adhesion prevention
JP2006306765A (ja) *	2005-04-27	2006-11-09	Nippon Tenganyaku Kenkyusho:Kk	トラニラスト水性点眼液
MX352516B (es) *	2006-07-05	2017-04-06	Fibrotech Therapeutics Pty Ltd	Compuestos terapeuticos.
CA2709937C (fr) *	2007-12-21	2016-03-22	Fibrotech Therapeutics Pty Ltd	Analogues halogenes d'agents antifibrotiques
EP2947073B1 (fr)	2009-10-22	2019-04-03	Fibrotech Therapeutics Pty Ltd	Analogues cycliques fusionnés d'agents antifibrotiques
CN103140215A (zh) *	2010-07-21	2013-06-05	爱尔康研究有限公司	具有提高的溶解度特征的药物组合物
JP7191515B2 (ja) *	2017-01-17	2022-12-19	ロート製薬株式会社	眼科組成物
SG11201907139UA (en)	2017-02-03	2019-09-27	Certa Therapeutics Pty Ltd	Anti-fibrotic compounds
JP6427244B2 (ja) *	2017-10-03	2018-11-21	ロート製薬株式会社	点眼剤
TWI651095B (zh) *	2017-10-18	2019-02-21	晶碩光學股份有限公司	具有抗敏舒緩效果的眼用產品
CN109718376B (zh) *	2017-10-27	2022-01-25	晶硕光学股份有限公司	具有抗敏舒缓效果的眼用产品
US11078155B2 (en)	2018-08-14	2021-08-03	Nuformix Technologies Limited	Crystalline tranilast salts and their pharmaceutical use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1296518A (fr) *	1959-04-25	1962-06-22		Véhicule liquide pour collyre
US3856919A (en) *	1970-06-08	1974-12-24	Burton Parsons Chemicals Inc	Ophthalmic solution
US4070484A (en) *	1973-01-18	1978-01-24	Kissei Pharmaceutical Co., Ltd.	Antiallergic composition containing aromatic carboxylic amide derivatives and method of using the same
US4029817A (en) *	1973-09-24	1977-06-14	Allergan Pharmaceuticals	Soft contact lens preserving solutions
JPS6144811A (ja) *	1984-08-10	1986-03-04	Ss Pharmaceut Co Ltd	徐放性ジクロフエナクナトリウム製剤
US4666929A (en) *	1985-04-10	1987-05-19	Shiseido Company Ltd.	Anthranilic acid ester derivatives and antiinflammatory and analgetic external preparations containing the same
CA1291036C (fr) *	1986-04-23	1991-10-22	Edwin I. Stoltz	Administration de medicaments par voie nasale
KR910002669B1 (ko) *	1986-12-25	1991-05-03	데이산세이야꾸 가부시끼가이샤	서방성 과립 및 그를 함유하는 지속성 복합과립

1989
- 1989-04-04 JP JP1085521A patent/JPH07116029B2/ja not_active Expired - Lifetime
- 1989-11-03 AU AU44384/89A patent/AU623191B2/en not_active Ceased
- 1989-11-07 DK DK555089A patent/DK555089A/da not_active Application Discontinuation
- 1989-11-11 KR KR1019890016341A patent/KR940002660B1/ko not_active Expired - Lifetime
- 1989-11-16 EP EP89311879A patent/EP0391002B1/fr not_active Expired - Lifetime
- 1989-11-16 AT AT89311879T patent/ATE103808T1/de not_active IP Right Cessation
- 1989-11-16 DE DE68914438T patent/DE68914438T2/de not_active Expired - Fee Related
- 1989-11-16 ES ES89311879T patent/ES2063146T3/es not_active Expired - Lifetime
- 1989-11-17 CA CA002003190A patent/CA2003190C/fr not_active Expired - Fee Related
- 1989-11-17 FI FI895492A patent/FI95773C/fi not_active IP Right Cessation
- 1989-11-17 NO NO894602A patent/NO176346C/no unknown
1991
- 1991-04-03 US US07/680,786 patent/US5356620A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH02264716A (ja)	1990-10-29
FI95773B (fi)	1995-12-15
US5356620A (en)	1994-10-18
NO176346B (no)	1994-12-12
HK1003780A1 (en)	1998-11-06
EP0391002B1 (fr)	1994-04-06
KR900015722A (ko)	1990-11-10
CA2003190C (fr)	1997-04-29
NO894602L (no)	1990-10-05
AU623191B2 (en)	1992-05-07
EP0391002A3 (fr)	1991-06-26
NO894602D0 (no)	1989-11-17
AU4438489A (en)	1990-10-11
ES2063146T3 (es)	1995-01-01
DK555089A (da)	1990-10-05
EP0391002A2 (fr)	1990-10-10
DE68914438T2 (de)	1994-07-28
KR940002660B1 (ko)	1994-03-28
JPH07116029B2 (ja)	1995-12-13
FI895492A0 (fi)	1989-11-17
ATE103808T1 (de)	1994-04-15
DE68914438D1 (de)	1994-05-11
NO176346C (no)	1995-03-22
DK555089D0 (da)	1989-11-07
FI95773C (fi)	1996-03-25

Legal Events

Date	Code	Title	Description
1994-07-15	EEER	Examination request
2007-11-19	MKLA	Lapsed

Publication	Publication Date	Title
EP0391002A3 (fr)	1991-06-26	Compositions pharmaceutiques contenant de l'acide anthranilique N-(3-4-diméthoxycinnamoyl)
AU616838B2 (en)	1991-11-07	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro- 2h-benzopyran or dihydrobenzodioxin)carboxamide derivatives
BR0213242A (pt)	2004-09-28	Composto ou um seu sal ou solvato, composto e seus sais de adição de ácido fisiologicamente aceitáveis, composição farmacêutica, método de tratamento de um ou mais distúrbios, uso de um composto, e, processo de preparação de um composto
AU617918B2 (en)	1991-12-05	2-aminopyrimidinone derivatives
CA2007181A1 (fr)	1990-07-06	Compose pharmaceutique a liberation continue
HK129093A (en)	1993-12-03	N-tert-butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl)isoquinoline-3-carboxamide & asparaginyl derivatives thereof
PH25504A (en)	1991-07-24	Novel substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides pharmaceutical composition containing said compound, method of use thereof
NZ236168A (en)	1993-05-26	Stereochemically pure r- or s- piperazinealkanamides; pharmaceutical compositions, methods of treatment and preparation
IE892535L (en)	1990-02-05	Antipsychotic 3-piperazinylbenzazole derivatives
MY108482A (en)	1996-09-30	Compounds.
HUT55598A (en)	1991-06-28	Fungicidal composition comprising new amino acid amide derivatives as active ingredient and process for producing the active ingredients
PT81246A (en)	1985-11-01	Amide derivatives
AU5879798A (en)	1998-09-08	Agents inhibiting progress of pterygium and postoperative recurrence of the same
CA2395438A1 (fr)	2001-07-05	Compositions seches contenant un acide amine hydrophobe
HUT51622A (en)	1990-05-28	Process for producing 3-piperidinole-indazole derivatives and pharmaceutical preparations having effect against high blood pressure containing these compounds as active substance
RU99108789A (ru)	2001-02-10	Ингибитор субэпителиального помутнения роговицы