CA2004646A1 - Protease, transcriptase inverse et endonucleases de retrovirus, et methode de production de ces enzymes - Google Patents

Protease, transcriptase inverse et endonucleases de retrovirus, et methode de production de ces enzymes

Info

Publication number
CA2004646A1
CA2004646A1 CA2004646A CA2004646A CA2004646A1 CA 2004646 A1 CA2004646 A1 CA 2004646A1 CA 2004646 A CA2004646 A CA 2004646A CA 2004646 A CA2004646 A CA 2004646A CA 2004646 A1 CA2004646 A1 CA 2004646A1
Authority
CA
Canada
Prior art keywords
retroviral
protease
proteins
reverse transcriptase
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2004646A
Other languages
English (en)
Other versions
CA2004646C (fr
Inventor
Atsusi Saito
Hideo Shinagawa
Atsuo Nakata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation for Microbial Diseases of Osaka University BIKEN
Original Assignee
Research Foundation for Microbial Diseases of Osaka University BIKEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1088411A external-priority patent/JP2852431B2/ja
Application filed by Research Foundation for Microbial Diseases of Osaka University BIKEN filed Critical Research Foundation for Microbial Diseases of Osaka University BIKEN
Publication of CA2004646A1 publication Critical patent/CA2004646A1/fr
Application granted granted Critical
Publication of CA2004646C publication Critical patent/CA2004646C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
    • C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002004646A 1988-12-07 1989-12-05 Protease, transcriptase inverse et endonucleases de retrovirus, et methode de production de ces enzymes Expired - Fee Related CA2004646C (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP30942788 1988-12-07
JP309,427/1988 1988-12-07
JP1088411A JP2852431B2 (ja) 1988-12-07 1989-04-06 レトロウイルスのプロテアーゼ、逆転写酵素及びエンドヌクレアーゼ、並びにこれ等の酵素の製法
JP88,411/1989 1989-04-06

Publications (2)

Publication Number Publication Date
CA2004646A1 true CA2004646A1 (fr) 1990-06-07
CA2004646C CA2004646C (fr) 1999-10-05

Family

ID=26429797

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002004646A Expired - Fee Related CA2004646C (fr) 1988-12-07 1989-12-05 Protease, transcriptase inverse et endonucleases de retrovirus, et methode de production de ces enzymes

Country Status (9)

Country Link
EP (1) EP0372904B1 (fr)
AT (1) ATE112318T1 (fr)
AU (1) AU643942B2 (fr)
CA (1) CA2004646C (fr)
DE (1) DE68918563T2 (fr)
DK (1) DK612889A (fr)
HU (1) HU209835B (fr)
MY (1) MY104975A (fr)
NZ (1) NZ231593A (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT62654A (en) * 1990-05-28 1993-05-28 Univ Osaka Res Found Process for producing plasmid capable of expressing retrovirus gene and processing it after translation, as well its expression products
WO1992011028A1 (fr) * 1990-12-19 1992-07-09 Epitope, Inc. Vaccin a transcriptase inverse contre le vih
EP0555797A1 (fr) * 1992-02-10 1993-08-18 Becton, Dickinson and Company Solution tampon universelle pour endonucléases de réstriction
DE69604051T2 (de) * 1995-01-27 1999-12-16 The Government Of The United States Of America, As Represented By The Secretary Verfahren zum sensitiven nachweis von reverser transcriptase
US6242187B1 (en) 1996-01-29 2001-06-05 Virologic, Inc. Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
EP0852626B1 (fr) * 1996-01-29 2002-04-03 Virologic, Inc. Compositions et procedes pour determiner la sensibilite et la resistance vis-a-vis de medicaments antiviraux et criblage de medicaments antiviraux

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7512287A (en) * 1986-05-20 1987-12-22 Dana-Farber Cancer Institute Expression of human t-cell lymphotropic virus (htlv-iii)reve rse transcriptase and uses thereof

Also Published As

Publication number Publication date
ATE112318T1 (de) 1994-10-15
MY104975A (en) 1994-07-30
AU643942B2 (en) 1993-12-02
HUT54412A (en) 1991-02-28
DK612889D0 (da) 1989-12-05
AU4590889A (en) 1990-08-02
EP0372904A3 (fr) 1991-09-25
NZ231593A (en) 1992-07-28
DE68918563D1 (de) 1994-11-03
HU896176D0 (en) 1990-02-28
EP0372904A2 (fr) 1990-06-13
DE68918563T2 (de) 1995-02-23
EP0372904B1 (fr) 1994-09-28
DK612889A (da) 1990-06-08
CA2004646C (fr) 1999-10-05
HU209835B (en) 1994-11-28

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