CA2004695A1 - Phospholipide nucleosides - Google Patents

Phospholipide nucleosides

Info

Publication number
CA2004695A1
CA2004695A1 CA2004695A CA2004695A CA2004695A1 CA 2004695 A1 CA2004695 A1 CA 2004695A1 CA 2004695 A CA2004695 A CA 2004695A CA 2004695 A CA2004695 A CA 2004695A CA 2004695 A1 CA2004695 A1 CA 2004695A1
Authority
CA
Canada
Prior art keywords
nucleosides
phospholipid
pocl3
deoxy
nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2004695A
Other languages
English (en)
Other versions
CA2004695C (fr
Inventor
Rosanne Bonjouklian
Gerald Burr Grindey
Larry Wayne Hertel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CA2004695A1 publication Critical patent/CA2004695A1/fr
Application granted granted Critical
Publication of CA2004695C publication Critical patent/CA2004695C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002004695A 1988-12-12 1989-12-06 Phospholipide nucleosides Expired - Fee Related CA2004695C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28276688A 1988-12-12 1988-12-12
US07/282,766 1988-12-12

Publications (2)

Publication Number Publication Date
CA2004695A1 true CA2004695A1 (fr) 1990-06-12
CA2004695C CA2004695C (fr) 1999-08-10

Family

ID=23083035

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002004695A Expired - Fee Related CA2004695C (fr) 1988-12-12 1989-12-06 Phospholipide nucleosides

Country Status (5)

Country Link
EP (1) EP0376518B1 (fr)
JP (1) JP2817972B2 (fr)
CA (1) CA2004695C (fr)
DE (1) DE68924970T2 (fr)
ES (1) ES2081308T3 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563257A (en) * 1990-08-20 1996-10-08 Boehringer Mannheim Gmbh Phospholipid derivatives of nucleosides
US5484911A (en) * 1993-04-01 1996-01-16 Health Research, Inc. Nucleoside 5'-diphosphate conjugates of ether lipids
CA2284263A1 (fr) * 1997-03-24 1998-10-01 Eli Lilly And Company Acides difluoronucleosides-phosphoniques et leurs derives
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
DK1465615T3 (da) 2002-01-15 2012-11-12 Dartmouth College Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf
EP1567169A4 (fr) 2002-11-04 2009-10-21 Xenoport Inc Promedicaments de gemcitabine, leurs compositions pharmaceutiques et leurs utilisations
EP1464708A1 (fr) * 2003-04-03 2004-10-06 Pro. Bio. Sint. S.p.A. Procédé de préparation de fludarabine phosphate à partir de 2-fluoroadénine
GB0505781D0 (en) 2005-03-21 2005-04-27 Univ Cardiff Chemical compounds
CA2670099A1 (fr) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthese et activites biologiques de nouveaux composes tricycliques-bis-enones (tbe)
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
TWI492745B (zh) 2008-01-11 2015-07-21 Reata Pharmaceuticals Inc 合成的三萜系化合物及其使用於治療疾病之方法
WO2009129548A1 (fr) 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Modulateurs d’inflammation antioxydants : dérivés d’acide oléanolique homologués c-17
MX2010011435A (es) 2008-04-18 2011-01-25 Reata Pharmaceuticals Inc Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso.
TW201004627A (en) 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
DK2276493T3 (da) 2008-04-18 2019-01-02 Reata Pharmaceuticals Inc Antioxidative inflammationsmodulatorer: oleanolsyrederivater med amino- og andre modifikationer ved c-17
EA022588B1 (ru) 2008-04-18 2016-01-29 Ритэ Фамэсутикл, Инк. Антиоксидантные модуляторы воспаления: производные олеанолевой кислоты с насыщением в с-кольце
US9937128B2 (en) 2009-08-03 2018-04-10 The University Of North Carolina At Chapel Hill Liposomes comprising a calcium phosphate-containing precipitate
US9913822B2 (en) 2012-04-04 2018-03-13 Halozyme, Inc. Combination therapy with an anti-hyaluronan agent and therapeutic agent
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
BR112019022470A2 (pt) 2017-04-26 2020-05-12 I. Kalman Thomas Composto, composição, e, método para tratamento de um indivíduo com câncer.
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
WO2020041051A1 (fr) * 2018-08-20 2020-02-27 Cure Biopharma Inc. Promédicaments de gemcitabine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1264738A (fr) * 1984-12-04 1990-01-23 Eli Lilly And Company Traitement des tumeurs chez les mammiferes
CA1295998C (fr) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides et leur utilisation en tant qu'agents antineoplasiques
EP0262876B1 (fr) * 1986-09-27 1992-04-29 Toyo Jozo Kabushiki Kaisha Conjugué nucléoside-phospholipide

Also Published As

Publication number Publication date
DE68924970D1 (de) 1996-01-11
DE68924970T2 (de) 1996-05-15
ES2081308T3 (es) 1996-03-01
JPH02202896A (ja) 1990-08-10
CA2004695C (fr) 1999-08-10
EP0376518A1 (fr) 1990-07-04
JP2817972B2 (ja) 1998-10-30
EP0376518B1 (fr) 1995-11-29

Similar Documents

Publication Publication Date Title
CA2004695A1 (fr) Phospholipide nucleosides
MX167702B (es) Composicion farmaceutica anti-retroviral de 3'azid-2',3'-dideoxiuridina y metodo para elaborarla
AU3967689A (en) Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use
CA2215190A1 (fr) Arylphosphoramidates de nucleosides
MY102473A (en) Purine derivates and their pharmaceutical use
ES8707545A1 (es) Un metodo para preparar compuestos de 2-cloro-2'-desoxiadenosin-5'-fosfato.
ES8602840A1 (es) Un procedimiento para la preparacion de un nucleosido.
UA19333A (uk) Спосіб одержаhhя похідhих 5'-дезокси-5-фторцитидиhу
EP0498471A3 (en) Liposomes comprising a guanidino aminoglycoside
AU7944491A (en) Adenosine deaminase-stable anti-retroviral nucleosides
IL89796A0 (en) Bis-(hydroxymethyl)cyclobutyl purine and pyrimidine derivatives,pharmaceutical compositions containing the same and processes for the preparation thereof
AU4039097A (en) Propargylethoxyamino nucleotides
AU5831590A (en) 2-halo-9-(2-deoxy-2-fluoro-b-d-arabinofuranosyl) adenine nucleoside derivatives
EP0173059A3 (en) Method for the production of 2'-deoxyadenosine compounds
HUT48266A (en) Process for producing 2,3'-dideoxy-2'-fluoronukleozides and pharmaceutical compositions containing them as active componenets
EP0057548A3 (en) 7-beta-d-arabinofuranosyl-7h-pyrrolo(2,3-d)pyrimidine compounds useful as antiviral agents, pharmaceutical compositions containing the compounds, and processes for producing the compounds
ES8802363A1 (es) Procedimiento para la fabricacion de derivados nucleosidos
ES8707971A1 (es) Un metodo para producir un nucleosido de citosina
FI885094A7 (fi) Menetelmä terapeuttisesti käyttökelpoisen 2',3'-dideoksi-3'-fluoripyrimidiini- tai -puriininukleosidin valmistamiseksi
WO1990005736A3 (fr) Analogues de nucleosides
Egron et al. Anti-HIV pronucleotides: decomposition pathways and correlation with biological activities
MY103552A (en) Saccharide derivatives
ES8600321A1 (es) Un procedimiento para obtener compuestos de ribofuranosilselenazol-4-carboxamida-5'-fosfato
GB2160526B (en) Method for preparations of n6 - substituted 3',5' -cyclic adenosine monophosphate and salt thereof
DE3263508D1 (en) Phosphorylating agent and process for the phosphorylation of organic hydroxyl compounds

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed