CA2005420A1 - Antagonistes competitifs de la gonadoliberine - Google Patents

Antagonistes competitifs de la gonadoliberine

Info

Publication number: CA2005420A1
Authority: CA; Canada
Prior art keywords: competitive; antagonists; phe; ser; gonadoliberin
Prior art date: 1988-12-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2005420A

Other languages

English (en)

Other versions

CA2005420C (fr

Inventor

Cenek Kolar

Wolfgang Konig

Jurgen K. Sandow

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hoechst AG

Original Assignee

Hoechst AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-14

Filing date

1989-12-13

Publication date

1990-06-14

1989-12-13 Application filed by Hoechst AG filed Critical Hoechst AG

1990-06-14 Publication of CA2005420A1 publication Critical patent/CA2005420A1/fr

2000-01-18 Application granted granted Critical

2000-01-18 Publication of CA2005420C publication Critical patent/CA2005420C/fr

2009-12-13 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000005557 antagonist Substances 0.000 title abstract 2
230000002860 competitive effect Effects 0.000 title abstract 2
102000009165 Gonadoliberin Human genes 0.000 title 1
108050000048 Gonadoliberin Proteins 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
HQMLIDZJXVVKCW-UWTATZPHSA-N (2r)-2-aminopropanamide Chemical compound C[C@@H](N)C(N)=O HQMLIDZJXVVKCW-UWTATZPHSA-N 0.000 abstract 1
108700012941 GNRH1 Proteins 0.000 abstract 1
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical compound NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 abstract 1
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

CA002005420A 1988-12-14 1989-12-13 Antagonistes competitifs de la gonadoliberine Expired - Fee Related CA2005420C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DEP3842010.4		1988-12-14
DE3842010A DE3842010A1 (de)	1988-12-14	1988-12-14	Kompetitive gonadoliberin-antagonisten

Publications (2)

Publication Number	Publication Date
CA2005420A1 true CA2005420A1 (fr)	1990-06-14
CA2005420C CA2005420C (fr)	2000-01-18

Family

ID=6369104

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002005420A Expired - Fee Related CA2005420C (fr)	1988-12-14	1989-12-13	Antagonistes competitifs de la gonadoliberine

Country Status (16)

Country	Link
US (1)	US5071836A (fr)
EP (1)	EP0373545B1 (fr)
JP (1)	JPH02258798A (fr)
KR (1)	KR0142195B1 (fr)
AR (1)	AR247572A1 (fr)
AT (1)	ATE101622T1 (fr)
AU (1)	AU620184B2 (fr)
CA (1)	CA2005420C (fr)
DE (2)	DE3842010A1 (fr)
DK (1)	DK630289A (fr)
ES (1)	ES2061908T3 (fr)
IE (1)	IE62873B1 (fr)
IL (1)	IL92661A (fr)
NZ (1)	NZ231716A (fr)
PT (1)	PT92557B (fr)
ZA (1)	ZA899509B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5455232A (en) *	1992-02-04	1995-10-03	Piljac; Goran	Pharmaceutical preparation based on rhamnolipid
DK1380582T3 (da) *	1998-08-07	2006-12-04	Applied Research Systems	FSH-mimetika til behandling af infertilitet
CA2339018A1 (fr) *	1998-08-07	2000-02-17	Applied Research Systems Ars Holding N.V.	Analogues de l'hormone de stimulation des follicules pour traiter l'infertilite

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH11571A (en) *	1973-10-03	1978-03-31	American Home Prod	P-gui-d-phe-trp-ser-tyr-d-ala-leu-arg-pro-gly-nh2,its non-toxic salts and method of use thereof
DE2617646C2 (de) *	1976-04-22	1986-07-31	Hoechst Ag, 6230 Frankfurt	Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
FI832053L (fi) *	1982-06-10	1983-12-11	Syntex Inc	Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande
US4504467A (en) *	1983-10-21	1985-03-12	Eli Lilly And Company	Glycopeptide derivatives
US4530920A (en) *	1983-11-07	1985-07-23	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist
US4569927A (en) *	1984-02-23	1986-02-11	The Salk Institute For Biological Studies	GnRH Antagonists IV
DE3634435A1 (de) *	1986-10-09	1988-04-14	Hoechst Ag	Analoga von gonadoliberin mit verbesserter loeslichkeit, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
DK163689A (da) *	1988-04-08	1989-10-30	Sandoz Ag	Peptidderivater

1988
- 1988-12-14 DE DE3842010A patent/DE3842010A1/de not_active Withdrawn
1989
- 1989-10-12 AR AR89315650A patent/AR247572A1/es active
- 1989-12-09 AT AT89122757T patent/ATE101622T1/de not_active IP Right Cessation
- 1989-12-09 ES ES89122757T patent/ES2061908T3/es not_active Expired - Lifetime
- 1989-12-09 EP EP89122757A patent/EP0373545B1/fr not_active Expired - Lifetime
- 1989-12-09 DE DE89122757T patent/DE58906995D1/de not_active Expired - Fee Related
- 1989-12-12 KR KR1019890018352A patent/KR0142195B1/ko not_active Expired - Fee Related
- 1989-12-12 NZ NZ231716A patent/NZ231716A/en unknown
- 1989-12-12 IL IL9266189A patent/IL92661A/en unknown
- 1989-12-12 US US07/448,904 patent/US5071836A/en not_active Expired - Fee Related
- 1989-12-13 PT PT92557A patent/PT92557B/pt not_active IP Right Cessation
- 1989-12-13 JP JP1321603A patent/JPH02258798A/ja active Pending
- 1989-12-13 IE IE399089A patent/IE62873B1/en not_active IP Right Cessation
- 1989-12-13 ZA ZA899509A patent/ZA899509B/xx unknown
- 1989-12-13 DK DK630289A patent/DK630289A/da not_active Application Discontinuation
- 1989-12-13 CA CA002005420A patent/CA2005420C/fr not_active Expired - Fee Related
- 1989-12-13 AU AU46113/89A patent/AU620184B2/en not_active Ceased

Also Published As

Publication number	Publication date
PT92557A (pt)	1990-06-29
ATE101622T1 (de)	1994-03-15
EP0373545B1 (fr)	1994-02-16
DE58906995D1 (de)	1994-03-24
NZ231716A (en)	1991-12-23
KR900009693A (ko)	1990-07-05
AU620184B2 (en)	1992-02-13
EP0373545A3 (en)	1990-10-17
AU4611389A (en)	1990-06-21
JPH02258798A (ja)	1990-10-19
IE893990L (en)	1990-06-14
IL92661A0 (en)	1990-08-31
EP0373545A2 (fr)	1990-06-20
ES2061908T3 (es)	1994-12-16
IL92661A (en)	1994-05-30
IE62873B1 (en)	1995-03-08
KR0142195B1 (ko)	1998-07-01
AR247572A1 (es)	1995-01-31
US5071836A (en)	1991-12-10
DK630289A (da)	1990-06-15
DK630289D0 (da)	1989-12-13
DE3842010A1 (de)	1990-06-21
CA2005420C (fr)	2000-01-18
PT92557B (pt)	1995-08-09
ZA899509B (en)	1990-08-29

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Legal Events

Date	Code	Title	Description
1996-10-16	EEER	Examination request
2003-12-15	MKLA	Lapsed