CA2008940C - Method for the preparation of 4-(cyclic-amino)-2h-1-benzopyrans and 4-amino-3-hydroxy-2h-1-benzopyrans - Google Patents

Method for the preparation of 4-(cyclic-amino)-2h-1-benzopyrans and 4-amino-3-hydroxy-2h-1-benzopyrans Download PDF

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Publication number
CA2008940C
CA2008940C CA002008940A CA2008940A CA2008940C CA 2008940 C CA2008940 C CA 2008940C CA 002008940 A CA002008940 A CA 002008940A CA 2008940 A CA2008940 A CA 2008940A CA 2008940 C CA2008940 C CA 2008940C
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CA
Canada
Prior art keywords
alkyl
carbon atoms
compound
isomer
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002008940A
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English (en)
French (fr)
Other versions
CA2008940A1 (en
Inventor
Erol Ali Faruk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of CA2008940A1 publication Critical patent/CA2008940A1/en
Application granted granted Critical
Publication of CA2008940C publication Critical patent/CA2008940C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002008940A 1989-02-01 1990-01-30 Method for the preparation of 4-(cyclic-amino)-2h-1-benzopyrans and 4-amino-3-hydroxy-2h-1-benzopyrans Expired - Fee Related CA2008940C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8902118.2 1989-02-01
GB898902118A GB8902118D0 (en) 1989-02-01 1989-02-01 Chemical process

Publications (2)

Publication Number Publication Date
CA2008940A1 CA2008940A1 (en) 1990-08-01
CA2008940C true CA2008940C (en) 2000-12-05

Family

ID=10650905

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002008940A Expired - Fee Related CA2008940C (en) 1989-02-01 1990-01-30 Method for the preparation of 4-(cyclic-amino)-2h-1-benzopyrans and 4-amino-3-hydroxy-2h-1-benzopyrans

Country Status (23)

Country Link
US (1) US5126460A (de)
EP (1) EP0385584B1 (de)
JP (1) JP2859348B2 (de)
KR (1) KR0179364B1 (de)
AT (1) ATE123029T1 (de)
AU (1) AU626376B2 (de)
CA (1) CA2008940C (de)
DE (1) DE69019554T2 (de)
DK (1) DK0385584T3 (de)
ES (1) ES2074532T3 (de)
FI (1) FI900499A7 (de)
GB (1) GB8902118D0 (de)
GR (1) GR3017077T3 (de)
HK (1) HK1006308A1 (de)
HU (1) HUT58074A (de)
IE (1) IE66738B1 (de)
IL (1) IL93229A0 (de)
MA (1) MA21741A1 (de)
NO (1) NO900420L (de)
NZ (1) NZ232289A (de)
PT (1) PT92999B (de)
TW (1) TW206213B (de)
ZA (1) ZA90660B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5095016A (en) * 1989-08-11 1992-03-10 Kaken Pharmaceutical Co., Ltd. Benzopyran compounds, processes for their production and pharmaceutical compositions
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US7576094B2 (en) * 2004-12-13 2009-08-18 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors
KR101351454B1 (ko) * 2005-08-31 2014-01-14 아메데온, 인코포레이티드 위장 및 중추 신경계 장애의 치료에 유용한 입체이성질체 화합물의 합성 방법 및 중간 생성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
GB1548222A (en) * 1976-12-17 1979-07-04 Beecham Group Ltd Trans-4-heterocyclyl-3,4-dihydro-2h-benzo pyarn-3-ol derivatives
GB2107706A (en) * 1981-09-25 1983-05-05 Beecham Group Plc Benzopyrans
DE3368629D1 (en) * 1982-04-28 1987-02-05 Beecham Group Plc Novel chromenes and chromans
GB8308063D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
GB8308062D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
GB8313679D0 (en) * 1983-05-18 1983-06-22 Beecham Group Plc Active compounds
EP0139992B1 (de) * 1983-09-01 1988-12-28 Beecham Group Plc Chromanol-Derivate
US4876269A (en) * 1986-09-10 1989-10-24 E. I. Du Pont De Nemours And Company Benoz-fused cycloalkane trans-1,2-diamine derivatives
FR2615191B1 (fr) * 1987-05-16 1991-01-11 Sandoz Sa Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments
FI90343C (fi) * 1987-06-23 1994-01-25 Merck Patent Gmbh Menetelmä korkeaa verenpainetta alentavien ja rytmihäiriöitä vastustavien trans-2,2-dimetyylikroman-3-olijohdannaisten valmistamiseksi
DE3823533A1 (de) * 1988-07-12 1990-02-08 Beiersdorf Ag Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate
GB8918298D0 (en) * 1989-08-10 1989-09-20 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
KR900012931A (ko) 1990-09-03
FI900499A7 (fi) 1990-08-02
AU626376B2 (en) 1992-07-30
NO900420L (no) 1990-08-02
HU900588D0 (en) 1990-04-28
EP0385584B1 (de) 1995-05-24
PT92999A (pt) 1990-08-31
CA2008940A1 (en) 1990-08-01
ATE123029T1 (de) 1995-06-15
AU4892190A (en) 1990-08-09
MA21741A1 (fr) 1990-10-01
JP2859348B2 (ja) 1999-02-17
GR3017077T3 (en) 1995-11-30
NZ232289A (en) 1992-09-25
ES2074532T3 (es) 1995-09-16
TW206213B (de) 1993-05-21
HUT58074A (en) 1992-01-28
GB8902118D0 (en) 1989-03-22
HK1006308A1 (en) 1999-02-19
EP0385584A1 (de) 1990-09-05
PT92999B (pt) 1995-12-29
IE900342L (en) 1990-08-01
FI900499A0 (fi) 1990-01-31
ZA90660B (en) 1992-05-27
DK0385584T3 (da) 1995-07-17
IE66738B1 (en) 1996-02-07
KR0179364B1 (ko) 1999-03-20
DE69019554D1 (de) 1995-06-29
JPH02240079A (ja) 1990-09-25
IL93229A0 (en) 1990-11-05
US5126460A (en) 1992-06-30
NO900420D0 (no) 1990-01-30
DE69019554T2 (de) 1995-09-28

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