ES2074532T3 - Procedimiento para la preparacion de 4-(ciclico-amido)-2h-1-benzopiranos y 4-amino-3-hidroxi-2h-1-benzopiranos. - Google Patents

Procedimiento para la preparacion de 4-(ciclico-amido)-2h-1-benzopiranos y 4-amino-3-hidroxi-2h-1-benzopiranos.

Info

Publication number
ES2074532T3
ES2074532T3 ES90301063T ES90301063T ES2074532T3 ES 2074532 T3 ES2074532 T3 ES 2074532T3 ES 90301063 T ES90301063 T ES 90301063T ES 90301063 T ES90301063 T ES 90301063T ES 2074532 T3 ES2074532 T3 ES 2074532T3
Authority
ES
Spain
Prior art keywords
alkil
carbon
atoms
amino
benzopyrans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90301063T
Other languages
English (en)
Inventor
Erol Ali Faruk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of ES2074532T3 publication Critical patent/ES2074532T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE PRESENTA UN PROCESO PARA LA PREPARACION DE UN ISOMERO (3S,4R) PURO DE UN COMPUESTO DE FORMULA (A), EN LA QUE UNA ENTRE R1 Y R2 ES HIDROGENO Y LA OTRA SE SELECCIONA ENTRE ALKIL CARBONIL, ALCOXICARBONIL, ALKILCARBONILOXIDO, ALKIL HIDROXIMETIL, NITRO, ZIANO, CLORO, TRIFLUOROMETIL, ALKIL SULFINIL, ALKIL SULFONIL, ALCOXISULFINIL, ALCOXISULFONIL, ALKIL CARBONILAMINO, ALCOXICARBONILAMINO O AMINOSULFINIL, AMINOSULFONIL O AMINO CARBONIL, ESTANDO LA MOLECULA AMINO OPCIONALMENTE SUSTITUIDA POR UNO O DOS GRUPOS ALKIL, O ALKIL SULFINIL AMINO, ALKIL SULFONIL AMINO, ALCOXISULFONILAMINO O ALCOXISULFONILAMINO O ETILENICAMENTE SUSTITUIDO POR ALKIL CARBONIL, NITRO O CIANO O -C(ALKIL)NOH O -C(ALKIL)NNH2, TENIENDO LOS GRUPOS ALKIL O LAS MOLECULAS ALKIL DE LOS GRUPOS QUE CONTIENEN ALKIL ENTRE 1 Y 6 ATOMOS DE CARBONO; UNA DE ENTRE R3 Y R4 ES HIDROGENO O ALKIL QUE TIENE ENTRE 1 Y 4 ATOMOS DE CARBONO Y LA OTRA ES ALKIL QUE TIENE ENTRE 1 Y 4 ATOMOS DE CARBONO, R3 Y R4 JUNTAS SON POLIMETILENO C2-C5; R5 ES HIDROGENO, ALKIL QUE TIENE ENTRE 1 Y 3 ATOMOS DE CARBONO O AZIL QUE TIENE ENTRE 1 Y 8 ATOMOS DE CARBONO; Y N ES 1 O 2; EN DICHO COMPUESTO EL ANILLO PIRROLIDONIL O PIPERIDONIL SE FORMA CICLANDO UN COMPUESTO DE DIHIDROBENZOPIPIRANOL PRECURSOR APROPIADO QUE HAYA SIDO RESUELTO A LA CONFIGURACION (3S,4R) O UNA MEZCLA EN LA CUAL PREDOMINE LA CONFIGURACION (3S,4R) CON RESPECTO A LA CONFIGURACION (3R,4S)
ES90301063T 1989-02-01 1990-02-01 Procedimiento para la preparacion de 4-(ciclico-amido)-2h-1-benzopiranos y 4-amino-3-hidroxi-2h-1-benzopiranos. Expired - Lifetime ES2074532T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898902118A GB8902118D0 (en) 1989-02-01 1989-02-01 Chemical process

Publications (1)

Publication Number Publication Date
ES2074532T3 true ES2074532T3 (es) 1995-09-16

Family

ID=10650905

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90301063T Expired - Lifetime ES2074532T3 (es) 1989-02-01 1990-02-01 Procedimiento para la preparacion de 4-(ciclico-amido)-2h-1-benzopiranos y 4-amino-3-hidroxi-2h-1-benzopiranos.

Country Status (22)

Country Link
US (1) US5126460A (es)
EP (1) EP0385584B1 (es)
JP (1) JP2859348B2 (es)
KR (1) KR0179364B1 (es)
AT (1) ATE123029T1 (es)
AU (1) AU626376B2 (es)
CA (1) CA2008940C (es)
DE (1) DE69019554T2 (es)
DK (1) DK0385584T3 (es)
ES (1) ES2074532T3 (es)
FI (1) FI900499A7 (es)
GB (1) GB8902118D0 (es)
GR (1) GR3017077T3 (es)
HU (1) HUT58074A (es)
IE (1) IE66738B1 (es)
IL (1) IL93229A0 (es)
MA (1) MA21741A1 (es)
NO (1) NO900420L (es)
NZ (1) NZ232289A (es)
PT (1) PT92999B (es)
TW (1) TW206213B (es)
ZA (1) ZA90660B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5095016A (en) * 1989-08-11 1992-03-10 Kaken Pharmaceutical Co., Ltd. Benzopyran compounds, processes for their production and pharmaceutical compositions
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
AU2005316739A1 (en) * 2004-12-13 2006-06-22 Galileo Pharmaceuticals, Inc. Spiro derivatives as lipoxygenase inhibitors
AU2006284601B2 (en) * 2005-08-31 2012-12-20 Renexxion, Llc Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
GB1548222A (en) * 1976-12-17 1979-07-04 Beecham Group Ltd Trans-4-heterocyclyl-3,4-dihydro-2h-benzo pyarn-3-ol derivatives
EP0076075B1 (en) * 1981-09-25 1986-11-20 Beecham Group Plc Pharmaceutically active benzopyran compounds
DE3368629D1 (en) * 1982-04-28 1987-02-05 Beecham Group Plc Novel chromenes and chromans
GB8308063D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
GB8308062D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
GB8313679D0 (en) * 1983-05-18 1983-06-22 Beecham Group Plc Active compounds
DE3475786D1 (de) * 1983-09-01 1989-02-02 Beecham Group Plc Chromanol derivatives
US4876269A (en) * 1986-09-10 1989-10-24 E. I. Du Pont De Nemours And Company Benoz-fused cycloalkane trans-1,2-diamine derivatives
FR2615191B1 (fr) * 1987-05-16 1991-01-11 Sandoz Sa Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments
IL86798A (en) * 1987-06-23 1992-12-01 Sanofi Sa 2,2-dimethylchroman-3-ol derivatives, their preparation and pharmaceutical compositions containing them
DE3823533A1 (de) * 1988-07-12 1990-02-08 Beiersdorf Ag Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate
GB8918298D0 (en) * 1989-08-10 1989-09-20 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
HU900588D0 (en) 1990-04-28
FI900499A7 (fi) 1990-08-02
AU626376B2 (en) 1992-07-30
PT92999A (pt) 1990-08-31
NZ232289A (en) 1992-09-25
DE69019554D1 (de) 1995-06-29
HUT58074A (en) 1992-01-28
MA21741A1 (fr) 1990-10-01
DE69019554T2 (de) 1995-09-28
FI900499A0 (fi) 1990-01-31
EP0385584A1 (en) 1990-09-05
KR0179364B1 (ko) 1999-03-20
NO900420L (no) 1990-08-02
JPH02240079A (ja) 1990-09-25
DK0385584T3 (da) 1995-07-17
CA2008940C (en) 2000-12-05
US5126460A (en) 1992-06-30
ATE123029T1 (de) 1995-06-15
IE66738B1 (en) 1996-02-07
GB8902118D0 (en) 1989-03-22
IE900342L (en) 1990-08-01
CA2008940A1 (en) 1990-08-01
HK1006308A1 (en) 1999-02-19
ZA90660B (en) 1992-05-27
NO900420D0 (no) 1990-01-30
TW206213B (es) 1993-05-21
JP2859348B2 (ja) 1999-02-17
GR3017077T3 (en) 1995-11-30
EP0385584B1 (en) 1995-05-24
AU4892190A (en) 1990-08-09
IL93229A0 (en) 1990-11-05
PT92999B (pt) 1995-12-29
KR900012931A (ko) 1990-09-03

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