CA2010272A1 - Benzenesulfonamides et procede de preparation - Google Patents
Benzenesulfonamides et procede de preparationInfo
- Publication number
- CA2010272A1 CA2010272A1 CA2010272A CA2010272A CA2010272A1 CA 2010272 A1 CA2010272 A1 CA 2010272A1 CA 2010272 A CA2010272 A CA 2010272A CA 2010272 A CA2010272 A CA 2010272A CA 2010272 A1 CA2010272 A1 CA 2010272A1
- Authority
- CA
- Canada
- Prior art keywords
- carbon atoms
- alkyl
- hydrogen
- preparation
- tert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000008331 benzenesulfonamides Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000003524 antilipemic agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K31/00—Housing birds
- A01K31/18—Chicken coops or houses for baby chicks; Brooders including auxiliary features, e.g. feeding, watering, demanuring, heating, ventilation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Plural Heterocyclic Compounds (AREA)
- Paper (AREA)
- Photoreceptors In Electrophotography (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3905075.0 | 1989-02-18 | ||
| DE3905075A DE3905075A1 (de) | 1989-02-18 | 1989-02-18 | Benzolsulfonamide und verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2010272A1 true CA2010272A1 (fr) | 1990-08-18 |
| CA2010272C CA2010272C (fr) | 1999-11-16 |
Family
ID=6374463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002010272A Expired - Lifetime CA2010272C (fr) | 1989-02-18 | 1990-02-16 | Benzenesulfonamides et procede de preparation |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5143937A (fr) |
| EP (1) | EP0384279B1 (fr) |
| JP (1) | JP2851108B2 (fr) |
| KR (1) | KR0175298B1 (fr) |
| AT (1) | ATE104273T1 (fr) |
| AU (1) | AU622765B2 (fr) |
| CA (1) | CA2010272C (fr) |
| DE (2) | DE3905075A1 (fr) |
| DK (1) | DK0384279T3 (fr) |
| ES (1) | ES2052988T3 (fr) |
| FI (1) | FI900760A7 (fr) |
| IE (1) | IE63880B1 (fr) |
| IL (1) | IL93427A (fr) |
| NO (1) | NO172117C (fr) |
| NZ (1) | NZ232550A (fr) |
| PT (1) | PT93160B (fr) |
| ZA (1) | ZA901189B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA92970B (en) * | 1991-02-12 | 1992-10-28 | Hoechst Ag | Arylsulfonylureas,processes for their preparation,and their use as herbicides and growth regulators |
| DE4109735A1 (de) * | 1991-03-25 | 1992-10-01 | Boehringer Mannheim Gmbh | Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
| US6653331B2 (en) * | 1996-07-03 | 2003-11-25 | Pharmacia & Upjohn Company | Targeted drug delivery using sulfonamide derivatives |
| US6284923B1 (en) * | 1997-08-22 | 2001-09-04 | Tularik Inc | Substituted benzene compounds as antiproliferative and cholesterol lowering action |
| EP1053227B1 (fr) | 1998-01-29 | 2008-11-05 | Amgen Inc. | MODULATEURS DU RECEPTEUR ACTIVE DE LA PROLIFERATION DES PEROXYSOMES (PPAR$g(g)) |
| US6583157B2 (en) | 1998-01-29 | 2003-06-24 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| AU763687B2 (en) | 1998-06-25 | 2003-07-31 | Tularik Inc. | Arylsulfonanilide phosphates |
| US6153585A (en) | 1998-07-20 | 2000-11-28 | Tularik Inc. | Arylsulfonanilide derivatives |
| BR9913903A (pt) | 1998-09-23 | 2001-07-03 | Tularik Inc | Composto, método para tratar ou impedir um estado doentio, e, composição farmacêutica |
| US7041691B1 (en) * | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| DE19941559A1 (de) * | 1999-09-01 | 2001-03-15 | Aventis Pharma Gmbh | Verwendung von Bissulfonamiden zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Hyperlipidömie |
| WO2001082916A2 (fr) | 2000-05-03 | 2001-11-08 | Tularik Inc. | Compositions therapeutiques combinees et leurs methodes d'utilisation |
| US20030171399A1 (en) * | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| US6822001B2 (en) | 2000-11-03 | 2004-11-23 | Tularik Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
| US20050250854A1 (en) * | 2000-11-03 | 2005-11-10 | Amgen Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
| US7223761B2 (en) | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| AU2005221140A1 (en) * | 2004-03-08 | 2005-09-22 | Amgen Inc. | Therapeutic modulation of PPAR (gamma) activity |
| CN114129577B (zh) * | 2021-12-15 | 2022-07-12 | 徐州医科大学 | 苯磺酰胺化合物在制备预防和/或治疗衰老疾病的药物中的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA618769A (en) * | 1961-04-18 | Tagmann Eugen | Process for the manufacture of sulfamyl-anilines | |
| US2236168A (en) * | 1940-02-27 | 1941-03-25 | Du Pont | Lubricant |
| US3165550A (en) * | 1960-06-29 | 1965-01-12 | Pfizer & Co C | N-substituted p-benzenedisulfonamides |
| DE1278443C2 (de) * | 1963-11-30 | 1975-07-24 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 2,4-disulfonamid-1-chlorbenzolen |
| US3678039A (en) * | 1967-04-27 | 1972-07-18 | Lincoln Harvey Werner | 4-trifluoromethyl-anthranilic acids |
| US3737316A (en) * | 1971-08-31 | 1973-06-05 | Eastman Kodak Co | Two-equivalent sulfonamido couplers |
| CA1072359A (fr) * | 1974-10-08 | 1980-02-26 | Hiroyuki Konishi | Methode de controle de la croissance des plantes |
| US4013621A (en) * | 1975-04-29 | 1977-03-22 | Ciba-Geigy Corporation | Substituted sulfonamide derivatives of hindered phenols and stabilized compositions |
| DE3713757A1 (de) * | 1987-04-24 | 1988-11-10 | Hoechst Ag | Benzolsulfonamidderivate und verfahren zu ihrer herstellung |
-
1989
- 1989-02-18 DE DE3905075A patent/DE3905075A1/de not_active Withdrawn
-
1990
- 1990-02-14 AT AT90102859T patent/ATE104273T1/de not_active IP Right Cessation
- 1990-02-14 DE DE59005304T patent/DE59005304D1/de not_active Expired - Lifetime
- 1990-02-14 ES ES90102859T patent/ES2052988T3/es not_active Expired - Lifetime
- 1990-02-14 EP EP90102859A patent/EP0384279B1/fr not_active Expired - Lifetime
- 1990-02-14 DK DK90102859.7T patent/DK0384279T3/da active
- 1990-02-15 FI FI900760A patent/FI900760A7/fi not_active Application Discontinuation
- 1990-02-15 NZ NZ232550A patent/NZ232550A/en unknown
- 1990-02-15 PT PT93160A patent/PT93160B/pt active IP Right Grant
- 1990-02-16 IE IE58890A patent/IE63880B1/en not_active IP Right Cessation
- 1990-02-16 US US07/480,932 patent/US5143937A/en not_active Expired - Lifetime
- 1990-02-16 NO NO900750A patent/NO172117C/no not_active IP Right Cessation
- 1990-02-16 IL IL9342790A patent/IL93427A/en not_active IP Right Cessation
- 1990-02-16 ZA ZA901189A patent/ZA901189B/xx unknown
- 1990-02-16 AU AU49851/90A patent/AU622765B2/en not_active Expired
- 1990-02-16 KR KR1019900001886A patent/KR0175298B1/ko not_active Expired - Fee Related
- 1990-02-16 CA CA002010272A patent/CA2010272C/fr not_active Expired - Lifetime
- 1990-02-16 JP JP2034057A patent/JP2851108B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2010272C (fr) | 1999-11-16 |
| DE59005304D1 (de) | 1994-05-19 |
| JP2851108B2 (ja) | 1999-01-27 |
| DE3905075A1 (de) | 1990-08-30 |
| US5143937A (en) | 1992-09-01 |
| EP0384279B1 (fr) | 1994-04-13 |
| IL93427A0 (en) | 1990-11-29 |
| NO172117B (no) | 1993-03-01 |
| PT93160B (pt) | 1995-12-29 |
| JPH02255652A (ja) | 1990-10-16 |
| FI900760A0 (fi) | 1990-02-15 |
| NO900750D0 (no) | 1990-02-16 |
| NO900750L (no) | 1990-08-20 |
| DK0384279T3 (da) | 1994-08-08 |
| IE900588L (en) | 1990-08-18 |
| ATE104273T1 (de) | 1994-04-15 |
| IL93427A (en) | 1994-10-21 |
| IE63880B1 (en) | 1995-06-14 |
| AU622765B2 (en) | 1992-04-16 |
| NZ232550A (en) | 1992-05-26 |
| NO172117C (no) | 1993-06-09 |
| ES2052988T3 (es) | 1994-07-16 |
| EP0384279A1 (fr) | 1990-08-29 |
| KR0175298B1 (ko) | 1999-04-01 |
| FI900760A7 (fi) | 1990-08-19 |
| PT93160A (pt) | 1990-08-31 |
| AU4985190A (en) | 1990-08-23 |
| KR900012898A (ko) | 1990-09-03 |
| ZA901189B (en) | 1990-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |