CA2013449A1 - Acides 5-alkylquinolone carboxyliques antibacteriens - Google Patents

Acides 5-alkylquinolone carboxyliques antibacteriens

Info

Publication number: CA2013449A1
Authority: CA; Canada
Prior art keywords: alkylquinolonecarboxylic; antibacterial; acids; optionally substituted; hydrogen
Prior art date: 1989-04-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2013449A

Other languages

English (en)

Other versions

CA2013449C (fr

Inventor

Michael Schriewer

Klaus Grohe

Andreas Krebs

Uwe Petersen

Thomas Schenke

Ingo Haller

Karl G. Metzger

Rainer Endermann

Hans-Joachim Zeiler

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee

Bayer AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-03

Filing date

1990-03-30

Publication date

1990-10-03

1990-03-30 Application filed by Bayer AG filed Critical Bayer AG

1990-10-03 Publication of CA2013449A1 publication Critical patent/CA2013449A1/fr

2001-01-02 Application granted granted Critical

2001-01-02 Publication of CA2013449C publication Critical patent/CA2013449C/fr

2010-03-30 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000002253 acid Substances 0.000 title abstract 2
150000007513 acids Chemical class 0.000 title abstract 2
230000000844 anti-bacterial effect Effects 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

CA002013449A 1989-04-03 1990-03-30 Acides 5-alkylquinolone carboxyliques antibacteriens Expired - Fee Related CA2013449C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DEP3910663.2		1989-04-03
DE3910663A DE3910663A1 (de)	1989-04-03	1989-04-03	5-alkylchinoloncarbonsaeuren

Publications (2)

Publication Number	Publication Date
CA2013449A1 true CA2013449A1 (fr)	1990-10-03
CA2013449C CA2013449C (fr)	2001-01-02

Family

ID=6377683

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002013449A Expired - Fee Related CA2013449C (fr)	1989-04-03	1990-03-30	Acides 5-alkylquinolone carboxyliques antibacteriens

Country Status (16)

Country	Link
EP (1)	EP0391132A1 (fr)
JP (1)	JP3046035B2 (fr)
KR (1)	KR0156245B1 (fr)
CN (1)	CN1035945C (fr)
AU (1)	AU638005B2 (fr)
CA (1)	CA2013449C (fr)
DD (1)	DD298400A5 (fr)
DE (1)	DE3910663A1 (fr)
FI (1)	FI901615A7 (fr)
HU (2)	HUT58056A (fr)
IL (1)	IL93954A0 (fr)
NO (1)	NO173547C (fr)
NZ (1)	NZ233142A (fr)
PH (1)	PH27364A (fr)
PT (1)	PT93639A (fr)
ZA (1)	ZA902510B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4920120A (en) *	1988-01-25	1990-04-24	Warner-Lambert Company	Antibacterial agents
MY105136A (en) *	1988-04-27	1994-08-30	Daiichi Seiyaku Co	Optically active pyridonecarboxylic acid derivatives.
DD285601A5 (de) *	1988-07-15	1990-12-19	Bayer Ag,De	Verfahren zur herstellung von 7-(1-pyrrolidinyl)-3-chinolon- und naphthyridoncarbonsaeure-derivaten
DE59009705D1 (de) *	1989-04-17	1995-11-02	Bayer Ag	Verfahren zur Herstellung von 2,7-Diazabicyclo(3.3.0)octanen.
US5177210A (en) *	1989-04-17	1993-01-05	Bayer Aktiengesellschaft	Preparation of 2,7-diazabicyclo(3.3.0)octanes
US5241076A (en) *	1989-04-17	1993-08-31	Bayer Aktiengesellschaft	1,4-diazatricyclo [6.3.0.0]undecanes
EP0593766B1 (fr) *	1991-05-28	2000-09-06	Daiichi Pharmaceutical Co., Ltd.	Derive d'acide pyridonecarboxylique
DE4120646A1 (de) *	1991-06-22	1992-12-24	Bayer Ag	7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
TW209865B (fr) *	1992-01-10	1993-07-21	Bayer Ag
KR960003611B1 (ko) *	1992-07-23	1996-03-20	재단법인 한국화학연구소	신규한 디아자비시클로 알켄 유도체 및 그의 제조방법
DE4234078A1 (de) *	1992-10-09	1994-04-14	Bayer Ag	Chinoloncarbonsäuren
DE4234330A1 (de) *	1992-10-12	1994-04-14	Bayer Ag	Chinoloncarbonsäuren
JP3268098B2 (ja) *	1992-12-25	2002-03-25	第一製薬株式会社	二環性環状アミン誘導体
AU4272793A (en) *	1993-04-24	1994-11-21	Korea Research Institute Of Chemical Technology	Novel quinolone carboxylic acid derivatives and process for preparing the same
DE4329600A1 (de) *	1993-09-02	1995-03-09	Bayer Ag	Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
DE4339134A1 (de) *	1993-11-16	1995-05-18	Bayer Ag	1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate
DE4408212A1 (de) *	1994-03-11	1995-09-14	Bayer Ag	5-Vinyl- und 5-Ethinyl-chinolon- und -naphthyridon-carbonsäuren
DE19546249A1 (de) *	1995-12-12	1997-06-19	Bayer Ag	Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
ATE228130T1 (de) *	1996-02-23	2002-12-15	Bayer Ag	Gegebenenfalls substituierte 8-cyan-1-cyclopropyl-7-(2,8-diazabicyclo- 4.3.0)-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3- hinolincarbonsäuren und ihre derivate
DE19633805A1 (de) *	1996-02-23	1997-08-28	Bayer Ag	Gegenenenfalls substituierte 8-Cyan-l-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre Derivate
DE19652239A1 (de)	1996-12-16	1998-06-18	Bayer Ag	Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
DE19854356A1 (de) *	1998-11-25	2000-05-31	Bayer Ag	Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) *	1998-11-25	2000-05-31	Bayer Ag	Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854357A1 (de) *	1998-11-25	2000-05-31	Bayer Ag	Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
JP2006504690A (ja) *	2002-09-10	2006-02-09	ファイザー・プロダクツ・インク	Ｃｎｓ及びその他の障害の治療に有用なジアザ二環式化合物
SI1666477T1 (sl)	2003-09-10	2013-10-30	Kyorin Pharmaceutical Co., Ltd.	Derivati 7-(4-substituiran 3-ciklopropilaminometil-1-pirolidinil) kinolonkarboksilne kisline
US8222407B2 (en)	2007-05-24	2012-07-17	Kyorin Pharmaceutical Co., Ltd.	Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3522405A1 (de) *	1985-06-22	1987-01-02	Bayer Ag	1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln
DE3543513A1 (de) *	1985-12-10	1987-06-11	Bayer Ag	Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln
DE3601567A1 (de) *	1986-01-21	1987-07-23	Bayer Ag	7-(azabicycloalkyl)-chinoloncarbonsaeure- und -naphthyridon-carbonsaeure-derivate
DE3702393A1 (de) *	1987-01-28	1988-08-11	Bayer Ag	8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
US5591744A (en) *	1987-04-16	1997-01-07	Otsuka Pharmaceutical Company, Limited	Benzoheterocyclic compounds
US4920120A (en) *	1988-01-25	1990-04-24	Warner-Lambert Company	Antibacterial agents

1989
- 1989-04-03 DE DE3910663A patent/DE3910663A1/de not_active Withdrawn
1990
- 1990-03-20 NO NO901274A patent/NO173547C/no not_active IP Right Cessation
- 1990-03-21 EP EP90105293A patent/EP0391132A1/fr not_active Withdrawn
- 1990-03-28 AU AU52317/90A patent/AU638005B2/en not_active Ceased
- 1990-03-28 JP JP2077135A patent/JP3046035B2/ja not_active Expired - Lifetime
- 1990-03-30 CA CA002013449A patent/CA2013449C/fr not_active Expired - Fee Related
- 1990-03-30 FI FI901615A patent/FI901615A7/fi not_active Application Discontinuation
- 1990-03-30 IL IL93954A patent/IL93954A0/xx unknown
- 1990-03-30 NZ NZ233142A patent/NZ233142A/en unknown
- 1990-04-02 CN CN90101902A patent/CN1035945C/zh not_active Expired - Fee Related
- 1990-04-02 DD DD90339323A patent/DD298400A5/de not_active IP Right Cessation
- 1990-04-02 PT PT93639A patent/PT93639A/pt not_active Application Discontinuation
- 1990-04-02 ZA ZA902510A patent/ZA902510B/xx unknown
- 1990-04-03 HU HU912263A patent/HUT58056A/hu unknown
- 1990-04-03 KR KR1019900004548A patent/KR0156245B1/ko not_active Expired - Fee Related
- 1990-04-03 PH PH40321A patent/PH27364A/en unknown
- 1990-04-03 HU HU902055A patent/HU204811B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2013449C (fr)	2001-01-02
FI901615A7 (fi)	1990-10-04
AU638005B2 (en)	1993-06-17
KR900016186A (ko)	1990-11-12
NZ233142A (en)	1992-09-25
PT93639A (pt)	1990-11-20
AU5231790A (en)	1990-10-04
EP0391132A1 (fr)	1990-10-10
NO901274D0 (no)	1990-03-20
JP3046035B2 (ja)	2000-05-29
FI901615A0 (fi)	1990-03-30
ZA902510B (en)	1991-01-30
HUT58056A (en)	1992-01-28
PH27364A (en)	1993-06-21
HU204811B (en)	1992-02-28
KR0156245B1 (ko)	1998-11-16
NO173547C (no)	1993-12-29
IL93954A0 (en)	1990-12-23
HUT56563A (en)	1991-09-30
HU902055D0 (en)	1990-08-28
HU912263D0 (en)	1991-12-30
DE3910663A1 (de)	1990-10-04
NO173547B (no)	1993-09-20
JPH02289583A (ja)	1990-11-29
CN1046162A (zh)	1990-10-17
DD298400A5 (de)	1992-02-20
CN1035945C (zh)	1997-09-24
NO901274L (no)	1990-10-04

Legal Events

Date	Code	Title	Description
1997-01-21	EEER	Examination request
2003-03-31	MKLA	Lapsed

Publication	Publication Date	Title
CA2013449A1 (fr)	1990-10-03	Acides 5-alkylquinolone carboxyliques antibacteriens
CA2305807A1 (fr)	1999-04-15	Composes heterocycliques condenses substitues
IL78773A0 (en)	1986-08-31	2-(4-benzoyl-1-piperidyl)-1-phenylalkanol derivatives
DK428989D0 (da)	1989-08-30	Benzylaminderivater
EP0218541A3 (en)	1988-05-25	3-vinyl and 3-ethinyl-beta-carboline derivatives, their preparation and their use as medicaments
NZ326675A (en)	2000-01-28	Oxazoline arthropodicides
SE8001818L (sv)	1980-09-09	Merkaptoacyldihydropyrazolkarboxylsyraderivat
ES2002617A6 (es)	1988-09-01	Un procedimiento para la preparacion de gamma-carbolinas
MA20002A1 (fr)	1984-10-01	Nouveaux composes heterocycliques et leur preparation
EP0292051A3 (fr)	1990-03-21	Dérivés de la thiénopyridine
ES8608495A1 (es)	1986-06-16	Procedimiento para la obtencion de nuevos compuestos de aralquiltriazol
FI870254A0 (fi)	1987-01-21	Foerfarande foer framstaellning av 3-acylaminometylimidazo/1,2-a/pyridiner.
ATE123025T1 (de)	1995-06-15	2-amino-n-(((4-(aminocarbonyl)pyrimidin-2- yl>amino>alkyl>-pyrimidin-4- carbonsäureamidderivate, ihre herstellung und ihre anwendung in der therapeutica.
ES8407481A1 (es)	1984-10-01	"procedimiento para la preparacion de alfa-(1-triazolil)-ceto-derivados"
CA2118052A1 (fr)	1995-04-16	Derives du n-(aminosubstitue)pyrrole, leur procede de preparation et compositions herbicides
EP0159692A3 (fr)	1987-02-04	Dérivés annelés de la 4H-1,4-benzothiazine
CA2042355A1 (fr)	1991-04-28	Derives du sulfamidosulfomyluree et herbicides
FI863701L (fi)	1986-09-12	Propanolderivat.
ES8505669A1 (es)	1985-06-01	Procedimiento para la obtencion de derivados de triazolilmetil-piridiloximetil-carbinoles
CA2066364A1 (fr)	1993-10-17	Derives de la propargylamine psychoactifs
AU1147383A (en)	1983-08-25	Substituted oximoacetanilides
CA2036630A1 (fr)	1991-08-21	Derives du 1-phenoxycarbonyl 1-2-pyrrolidinone et agents nootropiques
CA2048053A1 (fr)	1992-02-04	2-amino-4-fluoroalkoxy-1,3,5-triazines et leur mode d'obtention
GR3015774T3 (en)	1995-07-31	Benzylketones and fongicides containing them.
ATE52514T1 (de)	1990-05-15	S-aralkyltrithiophosphonat-insektizide.