CA2014521A1 - N,n'-ditrimethoxybenzoyl piperazines substituees en position 2, procede de preparation et composes therapeutiques les contenant - Google Patents

N,n'-ditrimethoxybenzoyl piperazines substituees en position 2, procede de preparation et composes therapeutiques les contenant

Info

Publication number: CA2014521A1
Authority: CA; Canada
Prior art keywords: preparation process; compositions containing; therapeutic compositions; carbon atoms; ditrimethoxybenzoyl
Prior art date: 1989-04-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2014521A

Other languages

English (en)

Other versions

CA2014521C (fr

Inventor

Pierre Braquet

Jean-Jacques Godfroid

Eduardo Pirotzky

Francoise Heymans

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ipsen Pharma SAS

Original Assignee

Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-15

Filing date

1990-04-12

Publication date

1990-10-15

1990-04-12 Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS

1990-10-15 Publication of CA2014521A1 publication Critical patent/CA2014521A1/fr

1997-09-09 Application granted granted Critical

1997-09-09 Publication of CA2014521C publication Critical patent/CA2014521C/fr

2010-04-12 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title abstract 2
150000004885 piperazines Chemical class 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
239000004480 active ingredient Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229940066771 systemic antihistamines piperazine derivative Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

CA002014521A 1989-04-15 1990-04-12 N,n'-ditrimethoxybenzoyl piperazines substituees en position 2, procede de preparation et composes therapeutiques les contenant Expired - Fee Related CA2014521C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898908587A GB8908587D0 (en)	1989-04-15	1989-04-15	New 2-substituted n,n'-ditrimethoxybenzoyl piperazines
GB8908587.2		1989-04-15

Publications (2)

Publication Number	Publication Date
CA2014521A1 true CA2014521A1 (fr)	1990-10-15
CA2014521C CA2014521C (fr)	1997-09-09

Family

ID=10655129

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002014521A Expired - Fee Related CA2014521C (fr)	1989-04-15	1990-04-12	N,n'-ditrimethoxybenzoyl piperazines substituees en position 2, procede de preparation et composes therapeutiques les contenant

Country Status (32)

Country	Link
US (1)	US5019576A (fr)
JP (1)	JP2633709B2 (fr)
KR (1)	KR900016178A (fr)
AR (1)	AR247736A1 (fr)
AT (1)	AT399337B (fr)
AU (1)	AU631334B2 (fr)
BE (1)	BE1007245A3 (fr)
CA (1)	CA2014521C (fr)
CH (1)	CH681301A5 (fr)
DE (1)	DE4011925A1 (fr)
DK (1)	DK91890A (fr)
DZ (1)	DZ1407A1 (fr)
ES (1)	ES2019554A6 (fr)
FI (1)	FI92058C (fr)
FR (2)	FR2645743B1 (fr)
GB (2)	GB8908587D0 (fr)
GR (1)	GR1000355B (fr)
HK (1)	HK95092A (fr)
IE (1)	IE65058B1 (fr)
IN (1)	IN175799B (fr)
IT (1)	IT1241631B (fr)
LU (1)	LU87719A1 (fr)
MA (1)	MA21805A1 (fr)
NL (1)	NL9000798A (fr)
NO (1)	NO176098C (fr)
NZ (1)	NZ233250A (fr)
OA (1)	OA09446A (fr)
PT (1)	PT93736B (fr)
SE (1)	SE505186C2 (fr)
SG (1)	SG92092G (fr)
TN (1)	TNSN90051A1 (fr)
ZA (1)	ZA902566B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5344830A (en) *	1992-12-10	1994-09-06	Merck & Co., Inc.	N,N-diacylpiperazine tachykinin antagonists
IL111730A (en) *	1993-11-29	1998-12-06	Fujisawa Pharmaceutical Co	Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
US5883098A (en) *	1993-11-29	1999-03-16	Fujisawa Pharmaceutical Co., Ltd.	Piperazine derivatives
US5610165A (en) *	1994-02-17	1997-03-11	Merck & Co., Inc.	N-acylpiperidine tachykinin antagonists
US5795894A (en) *	1995-05-02	1998-08-18	Schering Corporation	Piperazino derivatives as neurokinn antagonists
JP4173912B2 (ja) *	1995-05-02	2008-10-29	シェーリングコーポレイション	ニューロキニンアンタゴニストとしてのピペラジノ誘導体
US5892039A (en) *	1995-08-31	1999-04-06	Schering Corporation	Piperazino derivatives as neurokinin antagonists
BR9610277A (pt) *	1995-08-31	1999-07-06	Schering Corp	Derivados de piperazino como antagonistas de neurowuinina
US5869488A (en) *	1996-05-01	1999-02-09	Schering Corporation	Piperazino derivatives as neurokinin antagonists
FR2780649B1 (fr) *	1998-07-06	2001-03-09	Univ Paris Vii Denis Diderot	Derives de la piperazine pour l'inhibition de la replication du virus de l'immunodeficience humaine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1243991A (en) *	1968-06-10	1971-08-25	Ici Ltd	Piperidine, morpholine and piperazine derivatives
FR2209560A1 (en) *	1972-12-07	1974-07-05	Degussa	N-(Trialkoxyaroyl)-ethylenediamine derivs - useful as cardioactive medicaments, exhibit anti-ischaemic activity comparable to nitroglycerin
IL85700A0 (en) *	1987-03-24	1988-08-31	Takeda Chemical Industries Ltd	1,4-disubstituted piperazine compounds,their production and use
EP0318235A3 (fr) *	1987-11-25	1991-05-02	Takeda Chemical Industries, Ltd.	Composés de pipérazine PAF-antagoniste 1,4-disubstitués et leur production
KR900018073A (ko) *	1988-05-23	1990-12-20	추후보충	피페라진 화합물
GB8823776D0 (en) *	1988-10-11	1988-11-16	Scras	New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
GB8823775D0 (en) *	1988-10-11	1988-11-16	Scras	New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines
US4997836A (en) *	1988-11-11	1991-03-05	Takeda Chemical Industries, Ltd.	Trisubstituted piperazine compounds, their production and use

1989
- 1989-04-15 GB GB898908587A patent/GB8908587D0/en active Pending
1990
- 1990-04-03 ZA ZA902566A patent/ZA902566B/xx unknown
- 1990-04-04 GB GB9007612A patent/GB2230262B/en not_active Expired - Lifetime
- 1990-04-05 NL NL9000798A patent/NL9000798A/nl not_active Application Discontinuation
- 1990-04-05 IN IN140DE1990D patent/IN175799B/en unknown
- 1990-04-06 SE SE9001269A patent/SE505186C2/sv not_active IP Right Cessation
- 1990-04-06 GR GR900100270A patent/GR1000355B/el unknown
- 1990-04-09 US US07/506,421 patent/US5019576A/en not_active Expired - Lifetime
- 1990-04-09 NZ NZ233250A patent/NZ233250A/en unknown
- 1990-04-10 LU LU87719A patent/LU87719A1/fr unknown
- 1990-04-10 CH CH1206/90A patent/CH681301A5/fr not_active IP Right Cessation
- 1990-04-10 NO NO901631A patent/NO176098C/no unknown
- 1990-04-10 AR AR90316593A patent/AR247736A1/es active
- 1990-04-10 MA MA22064A patent/MA21805A1/fr unknown
- 1990-04-11 ES ES9001056A patent/ES2019554A6/es not_active Expired - Lifetime
- 1990-04-11 DK DK091890A patent/DK91890A/da unknown
- 1990-04-11 IE IE131490A patent/IE65058B1/en not_active IP Right Cessation
- 1990-04-11 DZ DZ900066A patent/DZ1407A1/fr active
- 1990-04-11 BE BE9000408A patent/BE1007245A3/fr not_active IP Right Cessation
- 1990-04-11 PT PT93736A patent/PT93736B/pt not_active IP Right Cessation
- 1990-04-11 AT AT0086690A patent/AT399337B/de not_active IP Right Cessation
- 1990-04-12 DE DE4011925A patent/DE4011925A1/de not_active Ceased
- 1990-04-12 CA CA002014521A patent/CA2014521C/fr not_active Expired - Fee Related
- 1990-04-12 TN TNTNSN90051A patent/TNSN90051A1/fr unknown
- 1990-04-12 IT IT20020A patent/IT1241631B/it active IP Right Grant
- 1990-04-12 OA OA59775A patent/OA09446A/fr unknown
- 1990-04-12 FI FI901883A patent/FI92058C/fi not_active IP Right Cessation
- 1990-04-13 JP JP2096620A patent/JP2633709B2/ja not_active Expired - Lifetime
- 1990-04-13 FR FR909004797A patent/FR2645743B1/fr not_active Expired - Lifetime
- 1990-04-13 FR FR909004798A patent/FR2645859B1/fr not_active Expired - Lifetime
- 1990-04-14 KR KR1019900005198A patent/KR900016178A/ko not_active Ceased
- 1990-04-17 AU AU53261/90A patent/AU631334B2/en not_active Ceased
1992
- 1992-09-11 SG SG920/92A patent/SG92092G/en unknown
- 1992-11-26 HK HK950/92A patent/HK95092A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATA86690A (de)	1994-09-15
HK95092A (en)	1992-12-04
NO176098C (no)	1995-02-01
GB8908587D0 (en)	1989-06-01
MA21805A1 (fr)	1990-12-31
IN175799B (fr)	1995-08-26
PT93736A (pt)	1990-11-20
GR1000355B (el)	1992-06-25
NZ233250A (en)	1991-03-26
DK91890A (da)	1990-10-16
US5019576A (en)	1991-05-28
ES2019554A6 (es)	1991-06-16
NO901631D0 (no)	1990-04-10
AR247736A1 (es)	1995-03-31
AU5326190A (en)	1990-11-01
GB2230262A (en)	1990-10-17
TNSN90051A1 (fr)	1991-03-05
NO901631L (no)	1990-10-16
DK91890D0 (da)	1990-04-11
ZA902566B (en)	1991-01-30
SG92092G (en)	1992-12-04
FI901883A0 (fi)	1990-04-12
DZ1407A1 (fr)	2004-09-13
JP2633709B2 (ja)	1997-07-23
JPH02292266A (ja)	1990-12-03
GR900100270A (en)	1991-09-27
CA2014521C (fr)	1997-09-09
KR900016178A (ko)	1990-11-12
SE505186C2 (sv)	1997-07-14
FR2645743B1 (fr)	1992-06-05
BE1007245A3 (fr)	1995-05-02
IT1241631B (it)	1994-01-25
GB9007612D0 (en)	1990-05-30
LU87719A1 (fr)	1990-07-24
FI92058B (fi)	1994-06-15
DE4011925A1 (de)	1990-10-18
AU631334B2 (en)	1992-11-19
CH681301A5 (fr)	1993-02-26
FR2645859A1 (fr)	1990-10-19
SE9001269L (sv)	1990-10-16
IE65058B1 (en)	1995-10-04
PT93736B (pt)	1996-09-30
IT9020020A1 (it)	1991-10-12
NL9000798A (nl)	1990-11-01
SE9001269D0 (sv)	1990-04-06
AT399337B (de)	1995-04-25
IE901314L (en)	1990-10-15
GB2230262B (en)	1992-02-26
IT9020020A0 (it)	1990-04-12
OA09446A (fr)	1992-10-15
FR2645743A1 (fr)	1990-10-19
FR2645859B1 (fr)	1992-06-05
NO176098B (no)	1994-10-24
FI92058C (fi)	1994-09-26

Legal Events

Date	Code	Title	Description
1993-04-05	EEER	Examination request
2006-04-12	MKLA	Lapsed

Publication	Publication Date	Title
GB8711802D0 (en)	1987-06-24	Dithioacetal compounds
EP0256503A3 (en)	1989-07-19	Pyridinecarboxamide derivatives and their use as fungicide
ES2044836T3 (es)	1994-01-16	Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene.
MX9306831A (es)	1995-01-31	Nuevos compuestos heterociclicos.
ATE57919T1 (de)	1990-11-15	Triazinderivate, verfahren zur herstellung der derivate und die derivate als wirksamen bestandteil enthaltende herbizide.
HK95092A (en)	1992-12-04	2-substituted n,n-di-trimethoxybenzoyl piperazines and pharmaceutical uses thereof
ES2046641T3 (es)	1994-02-01	Composicion antitumoral.
DE69623497D1 (de)	2002-10-10	1-methylcarbapenem-derivate
MX9206930A (es)	1993-06-01	Nuevos compuestos
EP0785190A3 (fr)	1997-08-27
DK0420224T3 (da)	1993-04-05	Anthihepatopatisk middel
SE8903312L (sv)	1990-04-12	New 2-carbonyl substituted n,n'-di-(trimethoxybenzol)piperazines, process for preparing the same and therapeutical compounds containing them
MY100957A (en)	1991-06-15	Quinazolinone compounds and processes for the preparation thereof.
SE8903313D0 (sv)	1989-10-09	New 2-methoxycarbonyl substituted n,n'-di(trimethoxybenzol) piperazines, process for preparing the same and therapeutical compounds compounds containing
MY101628A (en)	1991-12-31	Sulfonamide compounds and salts thereof, herbicidal compositions containing them, and process for producing them.
GB2190587B (en)	1990-01-17	Prophylactic and curing composition for arteriosclerosis
EP0273357A3 (en)	1989-11-02	Fluorine-containing macrolide compounds, pharmaceutical compositions comprising the same and their use for the manufacture of medicaments