CA2016765A1 - Sels cristallins stables de monohydrate de 2',3'-didesoxyinosine, de monohydrate de 2',3'-didesoxy-2',3'-didehydrothymidine, et de hemihydrate de 2',3'-didesoxy-2'-fluoroinosine, hautement solubles dans l'eau et antiviraux - Google Patents

Sels cristallins stables de monohydrate de 2',3'-didesoxyinosine, de monohydrate de 2',3'-didesoxy-2',3'-didehydrothymidine, et de hemihydrate de 2',3'-didesoxy-2'-fluoroinosine, hautement solubles dans l'eau et antiviraux

Info

Publication number: CA2016765A1
Authority: CA; Canada
Prior art keywords: dideoxy; monohydrate; fluoroinosine; didehydrothymidine; dideoxyinosine
Prior art date: 1989-05-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2016765A

Other languages

English (en)

Other versions

CA2016765C (fr

Inventor

Murray A. Kaplan

Robert K. Perrone

Joseph B. Bogardus

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Squibb Co

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-15

Filing date

1990-05-14

Publication date

1990-11-15

1990-05-14 Application filed by Individual filed Critical Individual

1990-11-15 Publication of CA2016765A1 publication Critical patent/CA2016765A1/fr

1997-10-21 Application granted granted Critical

1997-10-21 Publication of CA2016765C publication Critical patent/CA2016765C/fr

2010-05-14 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

150000003839 salts Chemical class 0.000 title abstract 3
SLWSQPYUSBXANQ-BAJZRUMYSA-N 9-[(2r,3r,5s)-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one Chemical compound O1[C@H](CO)C[C@@H](F)[C@@H]1N1C(NC=NC2=O)=C2N=C1 SLWSQPYUSBXANQ-BAJZRUMYSA-N 0.000 title abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
TYOLIMOHEMBOPU-UOERWJHTSA-N 9-[(2r,5s)-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one;hydrate Chemical class O.O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 TYOLIMOHEMBOPU-UOERWJHTSA-N 0.000 title 1
230000000840 anti-viral effect Effects 0.000 title 1
BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
150000001767 cationic compounds Chemical group 0.000 abstract 1
229910001411 inorganic cation Chemical group 0.000 abstract 1
150000002892 organic cations Chemical group 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CA002016765A 1989-05-15 1990-05-14 Sels cristallins stables de monohydrate de 2',3'-didesoxyinosine, de monohydrate de 2',3'-didesoxy-2',3'-didehydrothymidine, et de hemihydrate de 2',3'-didesoxy-2'-fluoroinosine, hautement solubles dans l'eau et antiviraux Expired - Fee Related CA2016765C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35206589A	1989-05-15	1989-05-15
US352,065		1989-05-15

Publications (2)

Publication Number	Publication Date
CA2016765A1 true CA2016765A1 (fr)	1990-11-15
CA2016765C CA2016765C (fr)	1997-10-21

Family

ID=23383649

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002016765A Expired - Fee Related CA2016765C (fr)	1989-05-15	1990-05-14	Sels cristallins stables de monohydrate de 2',3'-didesoxyinosine, de monohydrate de 2',3'-didesoxy-2',3'-didehydrothymidine, et de hemihydrate de 2',3'-didesoxy-2'-fluoroinosine, hautement solubles dans l'eau et antiviraux

Country Status (11)

Country	Link
JP (1)	JP2926257B2 (fr)
CA (1)	CA2016765C (fr)
CZ (1)	CZ9602347A3 (fr)
DD (1)	DD298406A5 (fr)
MY (1)	MY116824A (fr)
NZ (1)	NZ233646A (fr)
PL (1)	PL163999B1 (fr)
SK (2)	SK279130B6 (fr)
TW (1)	TW233301B (fr)
YU (1)	YU92890A (fr)
ZA (1)	ZA903662B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7122207B2 (en)	1998-05-22	2006-10-17	Bristol-Myers Squibb Company	High drug load acid labile pharmaceutical composition

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4731121B2 (ja) *	2004-02-02	2011-07-20	協和発酵キリン株式会社	キサンチン誘導体水和物
WO2009119785A1 (fr) *	2008-03-28	2009-10-01	浜理薬品工業株式会社	Procédé de purification d'un composé d'éthynylthymidine
US8445669B2 (en) *	2008-04-10	2013-05-21	Hamari Chemicals, Ltd.	Production process of ethynylthymidine compounds from 5-methyluridine as a starting material

1990
- 1990-05-11 YU YU92890A patent/YU92890A/sh unknown
- 1990-05-11 NZ NZ23364690A patent/NZ233646A/xx unknown
- 1990-05-12 TW TW79103864A patent/TW233301B/zh active
- 1990-05-14 MY MYPI90000768A patent/MY116824A/en unknown
- 1990-05-14 ZA ZA903662A patent/ZA903662B/xx unknown
- 1990-05-14 CA CA002016765A patent/CA2016765C/fr not_active Expired - Fee Related
- 1990-05-14 PL PL28517590A patent/PL163999B1/pl not_active IP Right Cessation
- 1990-05-15 DD DD90340679A patent/DD298406A5/de unknown
- 1990-05-15 SK SK2372-90A patent/SK279130B6/sk unknown
- 1990-05-15 JP JP12326390A patent/JP2926257B2/ja not_active Expired - Lifetime
1996
- 1996-08-08 CZ CZ19962347A patent/CZ9602347A3/cs not_active IP Right Cessation
1997
- 1997-09-19 SK SK1273-97A patent/SK279253B6/sk unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7122207B2 (en)	1998-05-22	2006-10-17	Bristol-Myers Squibb Company	High drug load acid labile pharmaceutical composition

Also Published As

Publication number	Publication date
SK127397A3 (en)	1998-08-05
CZ288463B6 (en)	2001-06-13
JP2926257B2 (ja)	1999-07-28
JPH035477A (ja)	1991-01-11
DD298406A5 (de)	1992-02-20
SK237290A3 (en)	1998-07-08
YU92890A (sh)	1992-09-07
TW233301B (fr)	1994-11-01
PL163999B1 (pl)	1994-06-30
ZA903662B (en)	1991-01-30
CZ9602347A3 (en)	2001-06-13
PL285175A1 (en)	1991-01-14
MY116824A (en)	2004-04-30
SK279130B6 (sk)	1998-07-08
SK279253B6 (sk)	1998-08-05
NZ233646A (en)	1991-10-25
CA2016765C (fr)	1997-10-21

Similar Documents

Publication	Publication Date	Title
CA2053339A1 (fr)	1992-04-19	Hydroxymethyl(methylenecyclopentyl) purines et pyrimidines
CA2048110A1 (fr)	1992-01-31	Derives d'imidazopyridine et leur utilisation
CA2297294A1 (fr)	1990-11-15	Derives de phosphonomethoxymethylpurine/pyrimidine
CA2064634A1 (fr)	1992-10-05	Derives de 9-desoxo-8a-aza-8a-homoerythromycine a modifies en positions 4"- et 8a
IL73258A (en)	1987-11-30	6-(ar)alkyl-7-aminoazolo(1,5-a)pyrimidines,their preparation and their use as fungicides
EP0236935A3 (fr)	1989-02-22	Purine-nucléosides carboxyliques, leur production et utilisation
CA2038848A1 (fr)	1991-09-25	Derives de l'hydantoine
MY117092A (en)	2004-05-31	Chemotherapeutic pyrrolocarbazole derivatives
CA2016765A1 (fr)	1990-11-15	Sels cristallins stables de monohydrate de 2',3'-didesoxyinosine, de monohydrate de 2',3'-didesoxy-2',3'-didehydrothymidine, et de hemihydrate de 2',3'-didesoxy-2'-fluoroinosine, hautement solubles dans l'eau et antiviraux
AU617614B2 (en)	1991-11-28	Antiviral, highly water soluble, stable, crystalline salts of 2',3'-dideoxyinosine monohydrate, 2',3'-dideoxy-2',3'-didehydrothymidine monohydrate and 2',3'-dideoxy-2'-fluoroinosine hemihydrate
CA2099213A1 (fr)	1993-12-28	4-iminoquinolines, procedes d'obtention et utilisation
CA2128202A1 (fr)	1993-07-22	Derives alkyles de la trazodone agissant sur le snc
CA2056334A1 (fr)	1992-05-29	Methode de preparation de derives de la benzylphtalazinone et de ses sels
AU2508584A (en)	1984-09-06	N-arylpiperazine derivatives
ZA898342B (en)	1990-07-25	Substituted 3-aminosydnonimines,processes for their preparation and their use
PL312966A1 (en)	1996-05-27	Derivatives of thiocarbamoil
EP0370712A3 (fr)	1991-10-02	Dérivés de l'éthylamine et médicaments hypotenseurs les contenant
EP0429751A3 (en)	1991-07-24	Substituted 3-amino-sydnonimines, process for their preparation and their use
MXPA96001370A (es)	2004-08-19	Herbicidas de n-piridinil[1,2,4]triazol[1,5-c]pirimidina-2-sulfonamida.
CA2037733A1 (fr)	1991-09-09	Trifluoro- et chorodifluoromethoxypyrimidines et leur preparation
TH7375B (th)	1997-11-21	ผลึกเกลือ 2',3'-ไดดีออกซิไอโนซีน โมโนไฮเดรท 2',3'-ไดดีออกซิ-2',3'-ไดดีไฮโดรไธมิดีนโมโนไฮเดรท และ 2',3'-ไดดีออกซิ-2'-ฟลูออโรไอโนซีน เฮมิไฮเดรทสำหรับต่อต้านไวรัสซึ่งละลายน้ำได้ดีและเสถียร

Legal Events

Date	Code	Title	Description
1990-07-06	EEER	Examination request
2009-05-14	MKLA	Lapsed