CA2019005C - Derives pentapeptidiques anti-herpes ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl - Google Patents

Derives pentapeptidiques anti-herpes ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl Download PDF

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Publication number: CA2019005C
Authority: CA; Canada
Prior art keywords: alkyl; hydrogen; asp; phenyl; lower alkyl
Prior art date: 1990-06-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA002019005A

Other languages

English (en)

Other versions

CA2019005A1 (fr

Inventor

Robert Deziel

Neil Moss

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Canada Ltd

Original Assignee

Boehringer Ingelheim Canada Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-14

Filing date

1990-06-14

Publication date

2000-04-18

1990-06-14 Application filed by Boehringer Ingelheim Canada Ltd filed Critical Boehringer Ingelheim Canada Ltd

1990-06-14 Priority to CA002019005A priority Critical patent/CA2019005C/fr

1990-07-03 Priority to AT90112646T priority patent/ATE118785T1/de

1990-07-03 Priority to EP90112646A priority patent/EP0411334B1/fr

1990-07-03 Priority to DE69017113T priority patent/DE69017113T2/de

1990-07-05 Priority to NZ234376A priority patent/NZ234376A/en

1990-07-05 Priority to IL9498090A priority patent/IL94980A/en

1990-07-06 Priority to JP2179373A priority patent/JP2877909B2/ja

1991-12-14 Publication of CA2019005A1 publication Critical patent/CA2019005A1/fr

2000-04-18 Application granted granted Critical

2000-04-18 Publication of CA2019005C publication Critical patent/CA2019005C/fr

2010-06-14 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

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125000000753 cycloalkyl group Chemical group 0.000 title claims abstract description 23
230000003602 anti-herpes Effects 0.000 title description 4
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125000000217 alkyl group Chemical group 0.000 claims abstract description 94
239000001257 hydrogen Substances 0.000 claims abstract description 45
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 45
125000003545 alkoxy group Chemical group 0.000 claims abstract description 33
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 18
150000002431 hydrogen Chemical group 0.000 claims abstract description 13
125000001589 carboacyl group Chemical group 0.000 claims abstract description 12
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 11
125000000464 thioxo group Chemical group S=* 0.000 claims abstract description 6
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims abstract 4
-1 2-carboxyphenyl Chemical group 0.000 claims description 99
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 39
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 30
150000003839 salts Chemical class 0.000 claims description 23
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 21
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125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 14
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UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
229960004295 valine Drugs 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
230000029812 viral genome replication Effects 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
239000003643 water by type Substances 0.000 description 1

Landscapes

Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

CA002019005A 1989-07-07 1990-06-14 Derives pentapeptidiques anti-herpes ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl Expired - Fee Related CA2019005C (fr)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
CA002019005A CA2019005C (fr)	1990-06-14	1990-06-14	Derives pentapeptidiques anti-herpes ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl
EP90112646A EP0411334B1 (fr)	1989-07-07	1990-07-03	Dérivés pentapeptidiques antiherpès ayant une chaîne latérale d'acide aspartique substitué
DE69017113T DE69017113T2 (de)	1989-07-07	1990-07-03	Pentapeptidderivate, wirksam gegen Herpes, die eine ersetzte Asparaginsäureseitenkette enthalten.
AT90112646T ATE118785T1 (de)	1989-07-07	1990-07-03	Pentapeptidderivate, wirksam gegen herpes, die eine ersetzte asparaginsäureseitenkette enthalten.
NZ234376A NZ234376A (en)	1989-07-07	1990-07-05	Acylated n-terminal pentapeptides having an esterified or amidified aspartic acid residue and optionally substituted at the c-terminal by 5-1h-tetrazolyl; use in treatment of herpes virus infections
IL9498090A IL94980A (en)	1989-07-07	1990-07-05	History of Pentapeptide against Harpaz, with a side chain of converted aspartic acid, their preparation and pharmaceutical preparations containing them
JP2179373A JP2877909B2 (ja)	1989-07-07	1990-07-06	置換アスパラギン酸側鎖を有する抗ヘルペスペンタペプチド誘導体

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA002019005A CA2019005C (fr)	1990-06-14	1990-06-14	Derives pentapeptidiques anti-herpes ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl

Publications (2)

Publication Number	Publication Date
CA2019005A1 CA2019005A1 (fr)	1991-12-14
CA2019005C true CA2019005C (fr)	2000-04-18

Family

ID=4145232

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002019005A Expired - Fee Related CA2019005C (fr)	1989-07-07	1990-06-14	Derives pentapeptidiques anti-herpes ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl

Country Status (1)

Country	Link
CA (1)	CA2019005C (fr)

1990
- 1990-06-14 CA CA002019005A patent/CA2019005C/fr not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2019005A1 (fr)	1991-12-14

Legal Events

Date	Code	Title	Description
1996-02-05	EEER	Examination request
2003-06-16	MKLA	Lapsed

Publication	Publication Date	Title
EP0461546B1 (fr)	1995-03-22	Dérivés de peptides anti-herpès ayant une extrémité N-terminale contenant un groupe 1,4-dioxo-C4
CA1340681C (fr)	1999-07-27	Tetrapeptides antiherpetiques, a chaine laterale constituee d'acide aspartique avec substitution
US5552384A (en)	1996-09-03	Antiherpes compositions and method of use
EP0411332B1 (fr)	1995-12-06	Peptides antiviraux ayant une chaîne latérale 2-cétoalkylique d'acide aminé
EP0411334B1 (fr)	1995-02-22	Dérivés pentapeptidiques antiherpès ayant une chaîne latérale d'acide aspartique substitué
US5502036A (en)	1996-03-26	Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
CA1340684C (fr)	1999-07-27	Pentapeptides antiherpetiques
EP0411333B1 (fr)	1995-05-31	Dérivés tetrapeptidiques antiherpes ayant une chaîne latérale d'acide aspartique substituée
CA2019005C (fr)	2000-04-18	Derives pentapeptidiques anti-herpes ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl
AU683450B2 (en)	1997-11-13	Inhibitors of herpes viral ribonucleotide reductase
US5149778A (en)	1992-09-22	Cyclic peptides for treating herpes infections
US5648337A (en)	1997-07-15	Antiherpes pentapeptides
CA2019006C (fr)	2000-06-13	Derives tetrapeptidiques ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl
US5258493A (en)	1993-11-02	Cyclic peptides for treating herpes infections
NZ234373A (en)	1997-06-24	Acylated n-terminal tetrapeptides having an esterified or amidified aspartic acid residue and optionally substituted at the c-terminal by 5-1h-tetrazolyl; use in treatment of herpes virus infections