ATE118785T1 - Pentapeptidderivate, wirksam gegen herpes, die eine ersetzte asparaginsäureseitenkette enthalten. - Google Patents

Pentapeptidderivate, wirksam gegen herpes, die eine ersetzte asparaginsäureseitenkette enthalten.

Info

Publication number: ATE118785T1
Authority: AT; Austria
Prior art keywords: replaced; side chain; effective against; acid side; against herpes
Prior art date: 1989-07-07

Application number

AT90112646T

Other languages

English (en)

Inventor

Julian Adams

Pierre Louis Beaulieu

Robert Deziel

John Dimaio

Louis Grenier

Pierre Lavallee

Neil Moss

Original Assignee

Bio Mega Boehringer Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-07

Filing date

1990-07-03

Publication date

1995-03-15

1989-07-07 Priority claimed from CA000605091A external-priority patent/CA1340683C/en

1990-06-14 Priority claimed from CA002019005A external-priority patent/CA2019005C/en

1990-07-03 Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim

1995-03-15 Application granted granted Critical

1995-03-15 Publication of ATE118785T1 publication Critical patent/ATE118785T1/de

Links

CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical group OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 title 1
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
206010019973 Herpes virus infection Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003254 radicals Chemical class 0.000 abstract 1
125000000464 thioxo group Chemical group S=* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Virology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Cosmetics (AREA)

AT90112646T 1989-07-07 1990-07-03 Pentapeptidderivate, wirksam gegen herpes, die eine ersetzte asparaginsäureseitenkette enthalten. ATE118785T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA000605091A CA1340683C (en)	1989-07-07	1989-07-07	Antiherpes pentapeptides having a substituted aspartic acid side chain
CA002019005A CA2019005C (en)	1990-06-14	1990-06-14	Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain

Publications (1)

Publication Number	Publication Date
ATE118785T1 true ATE118785T1 (de)	1995-03-15

Family

ID=25672870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90112646T ATE118785T1 (de)	1989-07-07	1990-07-03	Pentapeptidderivate, wirksam gegen herpes, die eine ersetzte asparaginsäureseitenkette enthalten.

Country Status (6)

Country	Link
EP (1)	EP0411334B1 (de)
JP (1)	JP2877909B2 (de)
AT (1)	ATE118785T1 (de)
DE (1)	DE69017113T2 (de)
IL (1)	IL94980A (de)
NZ (1)	NZ234376A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5830864A (en) *	1992-03-12	1998-11-03	Boehringer Ingelheim (Canada), Ltd.	Antiherpes peptide derivatives having a ureido n-terminus
US5846941A (en) *	1992-03-12	1998-12-08	Boehringer Ingelheim (Canada) Ltd.	Isosteric antiherpes peptide derivatives II
ATE169931T1 (de)	1992-03-12	1998-09-15	Boehringer Ingelheim Ca Ltd	Isosterische peptidderivate gegen herpes
EP0618226B1 (de) *	1993-03-03	2000-11-29	Boehringer Ingelheim (Canada) Ltd.	Hemmstoff für Ribonukleotid-Reduktase von Herpesviren
CA2152541C (en) *	1995-06-23	1998-12-15	Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee	Herpes ribonucleotide reductase inhibitors
US5948935A (en) *	1997-01-23	1999-09-07	Boehringer Ingelheim (Canada) Ltd.	Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
JP5828217B2 (ja)	2011-04-15	2015-12-02	三菱マテリアル株式会社	ドリル

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4795740A (en) *	1986-05-20	1989-01-03	Cohen Eric A	Antiviral peptides and means for treating herpes infections
EP0292255A3 (de) *	1987-05-22	1990-08-22	Merck & Co. Inc.	Hemmungsstoff für Ribonukleotid-Reduktase

1990
- 1990-07-03 EP EP90112646A patent/EP0411334B1/de not_active Expired - Lifetime
- 1990-07-03 DE DE69017113T patent/DE69017113T2/de not_active Expired - Fee Related
- 1990-07-03 AT AT90112646T patent/ATE118785T1/de active
- 1990-07-05 IL IL9498090A patent/IL94980A/en unknown
- 1990-07-05 NZ NZ234376A patent/NZ234376A/en unknown
- 1990-07-06 JP JP2179373A patent/JP2877909B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0411334B1 (de)	1995-02-22
JPH03215497A (ja)	1991-09-20
EP0411334A1 (de)	1991-02-06
IL94980A (en)	1995-03-15
DE69017113D1 (de)	1995-03-30
IL94980A0 (en)	1991-06-10
DE69017113T2 (de)	1995-08-03
NZ234376A (en)	1997-05-26
JP2877909B2 (ja)	1999-04-05

Similar Documents

Publication	Publication Date	Title
EP0425429A3 (de)	1991-07-24	Lichtstabilisierte Tinten
ATE184194T1 (de)	1999-09-15	Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)- homoserinlacton
PL301581A1 (en)	1994-06-27	Novel hiv protease inhibitors, method of obtaining such inhibitors and pharmaceutical preparation
ATE217635T1 (de)	2002-06-15	Zyklische peptide mit antifungischer wirkung und verfahren zu ihrer herstellung
GR3020451T3 (en)	1996-10-31	Retroviral protease inhibitors
NZ236327A (en)	1993-05-26	Substituted pyrrolidines and piperidines, and use thereof for preparing amino acid derivatives
HUT47529A (en)	1989-03-28	Process for producing polyethyleneglycol-carbaminates and diagnostic and pharmaceutical compositions comprising such compounds
HU9502811D0 (en)	1995-11-28	N-acyl-sulfamic acid esters (or thioesters), n-acyl-sulfonamides and n-sulfonyl-carbamic-acid-esters (or thioesters) as hypercholesterolemic agents
IT1274250B (it)	1997-07-15	Dieteri utilizzabili nella preparazione di catalizzatori ziegler-natta
GR3024586T3 (en)	1997-12-31	Retroviral protease inhibitors
ATE118785T1 (de)	1995-03-15	Pentapeptidderivate, wirksam gegen herpes, die eine ersetzte asparaginsäureseitenkette enthalten.
DE69023977D1 (de)	1996-01-18	Antivirale Peptide, die eine 2-Ketoalkylaminosäureseitenkette enthalten.
ATE179423T1 (de)	1999-05-15	Phosphorsubstituierte isoprenderivate
AU7468581A (en)	1982-03-04	Removing cobalt(ii) from aqueous solutions
FI944187A0 (fi)	1994-09-12	Isosteeriset antiherpespeptidijohdannaiset
DE3888569D1 (de)	1994-04-28	Schmierölzusammensetzungen, die Antiverschleiss- oder Extremdruckadditive enthalten.
HU902612D0 (en)	1990-09-28	Process for the preparation of 4-phenylmethyl-1h-indole derivatives
ATE123294T1 (de)	1995-06-15	Antiherpes-tetrapeptid-derivate mit einer substituierten seitenkette aus asparaginsäure.
ATE144534T1 (de)	1996-11-15	Antiherpes-pentapeptide
CA2019005A1 (en)	1991-12-14	Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain
CA1267150C (en)	1990-03-27	THIABICYCLOHEPTANE SUBSTITUTION DERIVATIVES OF AMINO-PROSTAGLANDIN ANALOGS
CA2019006A1 (en)	1991-12-14	Antiherpes tetrapeptide derivatives having a cycloalkyl substituted aspartic acid side chain
ATE158576T1 (de)	1997-10-15	Alpha-aryl-alpha-hydroxy-beta- imidazolinylpropionsäureamide
DE69319266D1 (de)	1998-07-30	Peptidderivate mit einem Ureido-N-Terminus gegen Herpes
DE69514388D1 (de)	2000-02-10	Antiherpetische peptidomimetische verbindungen