CA2026041A1 - Deacetoxycephalosporine c hydroxylase - Google Patents

Deacetoxycephalosporine c hydroxylase

Info

Publication number: CA2026041A1
Authority: CA; Canada
Prior art keywords: hydroxylase; terminal sequence; fplc; dac; deacetoxycephalosporin
Prior art date: 1989-09-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2026041A

Other languages

English (en)

Other versions

CA2026041C (fr

Inventor

Wu-Kuang Yeh

Joe E. Dotzlaf

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-26

Filing date

1990-09-24

Publication date

1991-03-27

1990-09-24 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1991-03-27 Publication of CA2026041A1 publication Critical patent/CA2026041A1/fr

1999-09-07 Application granted granted Critical

1999-09-07 Publication of CA2026041C publication Critical patent/CA2026041C/fr

2010-09-24 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

108010031946 deacetoxycephalosporin C hydroxylase Proteins 0.000 title abstract 2
108010074633 Mixed Function Oxygenases Proteins 0.000 abstract 2
102000008109 Mixed Function Oxygenases Human genes 0.000 abstract 2
238000002523 gelfiltration Methods 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
235000011130 ammonium sulphate Nutrition 0.000 abstract 1
239000003957 anion exchange resin Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
NNQIJOYQWYKBOW-JWKOBGCHSA-N deacetoxycephalosporin C Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 NNQIJOYQWYKBOW-JWKOBGCHSA-N 0.000 abstract 1
239000000284 extract Substances 0.000 abstract 1
238000005194 fractionation Methods 0.000 abstract 1
238000012872 hydroxylapatite chromatography Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/06—Cephalosporin C; Derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)
Peptides Or Proteins (AREA)

CA002026041A 1989-09-26 1990-09-24 Deacetoxycephalosporine c hydroxylase Expired - Fee Related CA2026041C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41276189A	1989-09-26	1989-09-26
US07/412,761		1989-09-26

Publications (2)

Publication Number	Publication Date
CA2026041A1 true CA2026041A1 (fr)	1991-03-27
CA2026041C CA2026041C (fr)	1999-09-07

Family

ID=23634379

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002026041A Expired - Fee Related CA2026041C (fr)	1989-09-26	1990-09-24	Deacetoxycephalosporine c hydroxylase

Country Status (9)

Country	Link
US (1)	US5714363A (fr)
EP (1)	EP0420562B1 (fr)
JP (1)	JPH03206884A (fr)
AT (1)	ATE121453T1 (fr)
CA (1)	CA2026041C (fr)
DE (1)	DE69018749T2 (fr)
DK (1)	DK0420562T3 (fr)
ES (1)	ES2072400T3 (fr)
IL (1)	IL95764A (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6709859B1 (en) *	1986-01-31	2004-03-23	Beecham Group P.L.C.	Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
DE3789880T2 (de) *	1986-01-31	1994-09-08	Beecham Group Plc	Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
US5571910A (en) *	1994-12-09	1996-11-05	Schering Corporation	Process for the preparation of intermediates useful in the synthesis of cephalosporins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1252973A (en) *	1915-05-03	1918-01-08	Roessler & Hasslacher Chemical	Catalyzer and process of making the same.
US2689203A (en) *	1951-09-27	1954-09-14	Armour & Co	Preparation of stabilized catalase
US3242056A (en) *	1962-06-08	1966-03-22	Lysofrance Soc	Thermally stable lysozyme composition and process for preparing same
US3637462A (en) *	1969-04-21	1972-01-25	Wadley Res Inst & Blood Bank	Purification of enzymes
US3761420A (en) *	1970-06-08	1973-09-25	Staley Mfg Co A E	Stabilized liquid enzyme stain remover
US4536476A (en) *	1982-08-23	1985-08-20	Queen's University At Kingston	Stable epimerase reagent, cyclase reagent and ring expansion reagent for cell-free production of cephalosporins
US4693977A (en) *	1982-08-23	1987-09-15	Queen's University At Kingston	Enzyme immobilization for producing cephalosporin antibiotics

1990
- 1990-09-24 IL IL9576490A patent/IL95764A/en not_active IP Right Cessation
- 1990-09-24 CA CA002026041A patent/CA2026041C/fr not_active Expired - Fee Related
- 1990-09-25 ES ES90310447T patent/ES2072400T3/es not_active Expired - Lifetime
- 1990-09-25 AT AT90310447T patent/ATE121453T1/de not_active IP Right Cessation
- 1990-09-25 DK DK90310447.9T patent/DK0420562T3/da active
- 1990-09-25 EP EP90310447A patent/EP0420562B1/fr not_active Expired - Lifetime
- 1990-09-25 DE DE69018749T patent/DE69018749T2/de not_active Expired - Fee Related
- 1990-09-26 JP JP2260288A patent/JPH03206884A/ja active Pending
1992
- 1992-04-23 US US07/872,553 patent/US5714363A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH03206884A (ja)	1991-09-10
DE69018749D1 (de)	1995-05-24
US5714363A (en)	1998-02-03
DE69018749T2 (de)	1995-09-14
DK0420562T3 (da)	1995-06-26
EP0420562B1 (fr)	1995-04-19
EP0420562A1 (fr)	1991-04-03
IL95764A0 (en)	1991-06-30
ES2072400T3 (es)	1995-07-16
ATE121453T1 (de)	1995-05-15
CA2026041C (fr)	1999-09-07
IL95764A (en)	1995-03-15

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Legal Events

Date	Code	Title	Description
1997-01-29	EEER	Examination request
2006-09-25	MKLA	Lapsed