CA2033176C - Proteines de fusion d'hormones de croissance - Google Patents

Proteines de fusion d'hormones de croissance

Info

Publication number
CA2033176C
CA2033176C CA002033176A CA2033176A CA2033176C CA 2033176 C CA2033176 C CA 2033176C CA 002033176 A CA002033176 A CA 002033176A CA 2033176 A CA2033176 A CA 2033176A CA 2033176 C CA2033176 C CA 2033176C
Authority
CA
Canada
Prior art keywords
igf
amino acid
acid sequence
fusion protein
insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002033176A
Other languages
English (en)
Other versions
CA2033176A1 (fr
Inventor
Julian Richard Este Wells
Robert Michael King
Geoffrey Leonard Francis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes Biopharma DK AS
Original Assignee
Gropep Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gropep Ltd filed Critical Gropep Ltd
Publication of CA2033176A1 publication Critical patent/CA2033176A1/fr
Application granted granted Critical
Publication of CA2033176C publication Critical patent/CA2033176C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention se rapporte à un plasmide codant pour une protéine de fusion, comprenant un premier polypeptide produisant une activité d'hormone de croissance et un second polypeptide, lequel peut être constitué par un polypeptide du facteur de croissance d'insuline (IGF)-I ou IGF-II et de leurs analogues, de l'histone de poulet H2A.I ou des facteurs de transcription humaine SPI-Lac Z, une séquence de clivage optionnelle pouvant être placée entre le premier et le seocnd polypeptide. Cette protéine de fusion peut être utilisée: 1) pour traiter des déficiences de l'hormone de croissance; 2) pour supprimer les pertes de protéines corporelles à la suite d'un trauma, tel que brûlures ou infections; 3) pour augmenter les taux de croissance et l'efficacité de la transformation des aliments chez les animaux d'élevage; et 4) pour soutenir la croissance de cellules en culture.
CA002033176A 1989-06-09 1990-05-22 Proteines de fusion d'hormones de croissance Expired - Lifetime CA2033176C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPJ467289 1989-06-09
AUPJ4672 1989-06-09
PCT/AU1990/000210 WO1990015142A1 (fr) 1989-06-09 1990-05-22 Proteines de fusion pour hormones de croissance

Publications (2)

Publication Number Publication Date
CA2033176A1 CA2033176A1 (fr) 1990-12-10
CA2033176C true CA2033176C (fr) 1999-12-14

Family

ID=3773983

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002033176A Expired - Lifetime CA2033176C (fr) 1989-06-09 1990-05-22 Proteines de fusion d'hormones de croissance

Country Status (6)

Country Link
US (1) US5330971A (fr)
EP (1) EP0429586B1 (fr)
AT (1) ATE125869T1 (fr)
CA (1) CA2033176C (fr)
DE (1) DE69021335T2 (fr)
WO (1) WO1990015142A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977307A (en) * 1989-09-07 1999-11-02 Alkermes, Inc. Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
US5679771A (en) * 1990-02-13 1997-10-21 Gropep Pty. Ltd. Method for treating intestinal diseases
CA2074166C (fr) * 1990-02-13 2003-11-25 Francis J. Ballard Methode de traitement de maladies intestinales
US5210017A (en) * 1990-11-19 1993-05-11 Genentech, Inc. Ligand-mediated immunofunctional hormone binding protein assay method
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
DK0642585T3 (da) * 1992-05-18 2006-05-15 Genentech Inc Aktiviering af oligomeriserende receptorer ved anvendelse af fusionerede receptorligander
US5763584A (en) * 1992-05-18 1998-06-09 Genentech, Inc. Receptor activation with hepatocyte growth factor agonists
NZ260309A (en) * 1992-06-08 1997-07-27 Pharmacia Ab Substituted For K Use of 1gf-2 for prevention or treatment of nutritional or gastrointestinal disorders and promoting neonatal growth
JPH06510065A (ja) * 1992-06-08 1994-11-10 カイロン　コーポレーション 成長因子ｉｇｆ−ｉおよび／またはｉｇｆ−ｉｉの用法
US5444045A (en) * 1992-09-17 1995-08-22 Gropep, Pty. Ltd. Method of administering IGF-1, IGF-2, and analogs thereof to birds
WO1995013290A1 (fr) * 1993-11-12 1995-05-18 North Shore University Hospital Research Corporation Methode pour traiter la dystrophie musculaire
GB9526733D0 (en) * 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
JP4394279B2 (ja) * 1998-03-09 2010-01-06 ジーランド ファーマ アクティーゼルスカブ 酵素加水分解に対する傾向が減少した薬理学的に活性なペプチド複合体
AUPP298498A0 (en) * 1998-04-17 1998-05-07 Gropep Pty Ltd Matrix binding factor
AU1805200A (en) * 1998-12-10 2000-06-26 Samyang Genex Corporation Method of separating basic peptide or basic protein
AUPQ387599A0 (en) * 1999-11-05 1999-12-02 Metabolic Pharmaceuticals Limited Product and method for control of obesity
CN1296974A (zh) * 1999-11-23 2001-05-30 上海博容基因开发有限公司 一种新的多肽——人组蛋白h2a.21和编码这种多肽的多核苷酸
EP2206720A1 (fr) * 2000-04-12 2010-07-14 Human Genome Sciences, Inc. Protéines de fusion d'albumine
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
DE60143858D1 (de) * 2000-11-28 2011-02-24 Premacure Ab Reduzierung DES RISIKOS FÜR KOMPLIKATIONEN BEI FRÜHGEBURTEN
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
US20060084794A1 (en) * 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
US20050244931A1 (en) * 2001-04-12 2005-11-03 Human Genome Sciences, Inc. Albumin fusion proteins
AU2002332041A1 (en) * 2001-10-05 2003-04-22 Human Genome Sciences, Inc. Albumin fusion proteins
EP2261250B1 (fr) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. Protéines de fusion d'albumine et GCSF
CA2513213C (fr) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Proteines hybrides d'albumine
US7355018B2 (en) 2003-09-30 2008-04-08 Regeneron Pharmaceuticals, Inc. Modified IGF1 polypeptides with increased stability and potency
DK2241575T3 (en) 2005-01-07 2015-08-24 Regeneron Pharma IGF-1 fusion polypeptides and therapeutic uses thereof
EP1841443A4 (fr) * 2005-01-11 2012-05-02 Heart Failure Technologies Inc Methode et systeme pour le traitement de l'insuffisance cardiaque
WO2007068053A1 (fr) * 2005-12-15 2007-06-21 Gropep Limited Production de protéines par voie recombinante
WO2008035230A2 (fr) * 2006-09-18 2008-03-27 Novozymes Gropep Limited Compositions protéiques liquides
RU2016144057A (ru) 2014-04-10 2018-05-15 Байер Хелскеа Ллк Смешанный состав порошка среды и способ получения жидкой среды для культуры клеток
HUE057135T2 (hu) 2015-09-01 2022-04-28 Ncardia B V In vitro módszer egy humán pluripotens õssejtpopuláció kardiomiocita sejtpopulációvá történõ differenciálására

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK108685A (da) * 1984-03-19 1985-09-20 Fujisawa Pharmaceutical Co Vaekstfaktor i
US5028531A (en) * 1984-03-19 1991-07-02 Fujisawa Pharmaceutical Company, Ltd. IGF-I fusion proteins; protection of IGF-I from degradation by host cell; and processes for the production thereof
JPH0720993B2 (ja) * 1985-08-22 1995-03-08 グロペップ プロプライエタリー リミテッド 生長因子
AU613876B2 (en) * 1986-10-01 1991-08-15 Merck & Co., Inc. Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins
FR2619719B1 (fr) * 1987-09-01 1991-05-10 Sanofi Sa Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices
JPH01144981A (ja) * 1987-12-02 1989-06-07 Wakunaga Pharmaceut Co Ltd 蛋白質の製造
US5164370A (en) * 1987-12-24 1992-11-17 Gropep Pty. Ltd. Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2)

Also Published As

Publication number Publication date
ATE125869T1 (de) 1995-08-15
WO1990015142A1 (fr) 1990-12-13
DE69021335D1 (de) 1995-09-07
DE69021335T2 (de) 1996-04-11
EP0429586A1 (fr) 1991-06-05
US5330971A (en) 1994-07-19
CA2033176A1 (fr) 1990-12-10
EP0429586A4 (en) 1992-07-08
EP0429586B1 (fr) 1995-08-02

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