CA2050905A1 - Formules d'aerosol pour usage therapeutique - Google Patents

Formules d'aerosol pour usage therapeutique

Info

Publication number: CA2050905A1
Authority: CA; Canada
Prior art keywords: propelled; self; polypeptide; aerosol suspension; thr
Prior art date: 1989-02-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002050905A

Other languages

English (en)

Inventor

George R. Felt

Mark P. Warchol

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Rorer International Holdings Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-23

Filing date

1990-02-21

Publication date

1990-08-24

1990-02-21 Application filed by Individual filed Critical Individual

1990-08-24 Publication of CA2050905A1 publication Critical patent/CA2050905A1/fr

Status Abandoned legal-status Critical Current

Links

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HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
235000014304 histidine Nutrition 0.000 description 1
CVVIJWRCGSYCMB-UHFFFAOYSA-N hydron;piperazine;dichloride Chemical compound Cl.Cl.C1CNCCN1 CVVIJWRCGSYCMB-UHFFFAOYSA-N 0.000 description 1
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
229960000367 inositol Drugs 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
229940047124 interferons Drugs 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
229960001361 ipratropium bromide Drugs 0.000 description 1
KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
229940018448 isoproterenol hydrochloride Drugs 0.000 description 1
229960003091 labetalol hydrochloride Drugs 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229960004393 lidocaine hydrochloride Drugs 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
235000018977 lysine Nutrition 0.000 description 1
239000000463 material Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229940042006 metaproterenol sulfate Drugs 0.000 description 1
229960004269 methoxamine hydrochloride Drugs 0.000 description 1
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
229960001300 metoprolol tartrate Drugs 0.000 description 1
VLPIATFUUWWMKC-UHFFFAOYSA-N mexiletine Chemical compound CC(N)COC1=C(C)C=CC=C1C VLPIATFUUWWMKC-UHFFFAOYSA-N 0.000 description 1
229960003632 minoxidil Drugs 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
229960002715 nicotine Drugs 0.000 description 1
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
210000003300 oropharynx Anatomy 0.000 description 1
229960001789 papaverine Drugs 0.000 description 1
239000000813 peptide hormone Substances 0.000 description 1
238000010647 peptide synthesis reaction Methods 0.000 description 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical group N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
229960000244 procainamide Drugs 0.000 description 1
REQCZEXYDRLIBE-UHFFFAOYSA-N procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 description 1
229960002429 proline Drugs 0.000 description 1
229960004604 propranolol hydrochloride Drugs 0.000 description 1
AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol hydrochloride Natural products C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
ZMRUPTIKESYGQW-UHFFFAOYSA-N propranolol hydrochloride Chemical group [H+].[Cl-].C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 ZMRUPTIKESYGQW-UHFFFAOYSA-N 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
229960002052 salbutamol Drugs 0.000 description 1
229960000581 salicylamide Drugs 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
238000004062 sedimentation Methods 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000003637 steroidlike Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 description 1
229960001909 terazosin hydrochloride Drugs 0.000 description 1
KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 1
229960005105 terbutaline sulfate Drugs 0.000 description 1
WUBVEMGCQRSBBT-UHFFFAOYSA-N tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(OS(=O)(=O)C(F)(F)F)=CC1 WUBVEMGCQRSBBT-UHFFFAOYSA-N 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
229960000278 theophylline Drugs 0.000 description 1
229960002872 tocainide Drugs 0.000 description 1
229960002649 tolazoline hydrochloride Drugs 0.000 description 1
RULSWEULPANCDV-PIXUTMIVSA-N turanose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](C(=O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RULSWEULPANCDV-PIXUTMIVSA-N 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
125000005289 uranyl group Chemical group 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
229960000881 verapamil hydrochloride Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA002050905A 1989-02-23 1990-02-21 Formules d'aerosol pour usage therapeutique Abandoned CA2050905A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US31460589A	1989-02-23	1989-02-23
US314,605		1989-02-23

Publications (1)

Publication Number	Publication Date
CA2050905A1 true CA2050905A1 (fr)	1990-08-24

Family

ID=23220626

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002050905A Abandoned CA2050905A1 (fr)	1989-02-23	1990-02-21	Formules d'aerosol pour usage therapeutique

Country Status (6)

Country	Link
EP (1)	EP0460064A4 (fr)
JP (1)	JPH05508616A (fr)
AU (1)	AU5194990A (fr)
CA (1)	CA2050905A1 (fr)
FI (1)	FI913899A7 (fr)
WO (1)	WO1990009781A1 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993006862A1 (fr) *	1991-10-11	1993-04-15	Toray Industries, Inc.	Composition a base d'anticorps
JPH07503154A (ja) *	1992-01-21	1995-04-06	エス・アール・アイ・インターナシヨナル	微細化ポリペプチド薬剤の改良調製方法
US6582728B1 (en) *	1992-07-08	2003-06-24	Inhale Therapeutic Systems, Inc.	Spray drying of macromolecules to produce inhaleable dry powders
US5698672A (en) *	1995-04-04	1997-12-16	Zymogenetics, Inc.	Synthetic calcitonin mimetics
GB9612297D0 (en) *	1996-06-11	1996-08-14	Minnesota Mining & Mfg	Medicinal aerosol formulations
DE19733651A1 (de) *	1997-08-04	1999-02-18	Boehringer Ingelheim Pharma	Wässrige Aerosolzubereitungen enthaltend biologisch aktive Markomoleküle und Verfahren zur Erzeugung entsprechender Aerosole
GB9807232D0 (en) *	1998-04-03	1998-06-03	Univ Cardiff	Aerosol composition
US6458338B1 (en) *	1998-09-22	2002-10-01	Aeropharm Technology Incorporated	Amino acid stabilized medicinal aerosol formulations
US6136294C1 (en) *	1998-09-22	2002-09-24	Aeropharm Technology Inc	Amino acid stabilized medical aerosol formulation
US6540983B1 (en)	2000-01-25	2003-04-01	Aeropharm Technology Incorporated	Medical aerosol formulation
US6540982B1 (en)	2000-01-25	2003-04-01	Aeropharm Technology Incorporated	Medical aerosol formulation
US6585957B1 (en)	2000-01-25	2003-07-01	Aeropharm Technology Incorporated	Medicinal aerosol formulation
US6565833B1 (en)	2000-05-01	2003-05-20	Aeropharm Technology Incorporated	Medicinal aerosol formulation
US6468507B1 (en)	2000-05-01	2002-10-22	Aeropharm Technology, Inc.	Non-aqueous aerosol formulation comprising rosiglitazone maleate, a non-aqueous carrier, and an amino acid stabilizer
US6464959B1 (en)	2000-05-01	2002-10-15	Aeropharm Technology Incorporated	Non-aqueous aerosol suspension comprising troglitazone, a fluid propellant, and an amino acid stabilizer
US6548049B1 (en)	2000-05-01	2003-04-15	Aeropharm Technology Incorporated	Medicinal aerosol formulation
US6749845B2 (en)	2001-02-15	2004-06-15	Aeropharm Technology, Inc.	Modulated release particles for lung delivery
US7176278B2 (en)	2001-08-30	2007-02-13	Biorexis Technology, Inc.	Modified transferrin fusion proteins
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
ES2382982T3 (es)	2007-07-21	2012-06-15	Albany Molecular Research, Inc.	Indazoles sustituidos con 5-piridinona y composiciones farmacéuticas de los mismos
EP2674417A3 (fr)	2007-11-21	2014-04-09	Decode Genetics EHF	Inhibiteurs de pde4 biaryle pour le traitement de l'inflammation
EP2077132A1 (fr)	2008-01-02	2009-07-08	Boehringer Ingelheim Pharma GmbH & Co. KG	Dispositif distributeur, dispositif de stockage et procédé pour la distribution d'une formulation
BRPI0907122B8 (pt)	2008-01-11	2021-05-25	Albany Molecular Res Inc	compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos
US8297305B2 (en)	2008-01-28	2012-10-30	Kohler Co.	Valve assembly having an improved flow path
WO2010059836A1 (fr)	2008-11-20	2010-05-27	Decode Genetics Ehf	Composés bicycliques substitués à pont aza pour maladie cardiovasculaire et du système nerveux central
CA2750777C (fr)	2009-01-26	2018-04-03	Israel Institute For Biological Research	Composes spiro heterocycliques bicycliques
EP2414560B1 (fr)	2009-03-31	2013-10-23	Boehringer Ingelheim International GmbH	Procédé de revêtement d'une surface d'un composant
EP3508239B1 (fr)	2009-05-18	2020-12-23	Boehringer Ingelheim International GmbH	Adaptateur, dispositif d'inhalation et pulvérisateur
JP5658268B2 (ja)	2009-11-25	2015-01-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ネブライザ
US10016568B2 (en)	2009-11-25	2018-07-10	Boehringer Ingelheim International Gmbh	Nebulizer
MX2012005961A (es)	2009-11-25	2012-06-14	Boehringer Ingelheim Int	Nebulizador.
JP5874724B2 (ja)	2010-06-24	2016-03-02	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ネブライザ
WO2012130757A1 (fr)	2011-04-01	2012-10-04	Boehringer Ingelheim International Gmbh	Appareil médical pourvu d'un récipient
US9827384B2 (en)	2011-05-23	2017-11-28	Boehringer Ingelheim International Gmbh	Nebulizer
WO2013152894A1 (fr)	2012-04-13	2013-10-17	Boehringer Ingelheim International Gmbh	Pulvérisateur comprenant des moyens de détrompage
WO2015018904A1 (fr)	2013-08-09	2015-02-12	Boehringer Ingelheim International Gmbh	Nébuliseur
EP2835146B1 (fr)	2013-08-09	2020-09-30	Boehringer Ingelheim International GmbH	Atomiseur
WO2015169430A1 (fr)	2014-05-07	2015-11-12	Boehringer Ingelheim International Gmbh	Nébuliseur
MX383195B (es)	2014-05-07	2025-03-13	Boehringer Ingelheim Int	Recipiente, nebulizador y uso.
BR122022010094B1 (pt)	2014-05-07	2023-10-03	Boehringer Ingelheim International Gmbh	Dispositivo indicador e recipiente
AU2019240065A1 (en)	2018-03-20	2020-09-24	Icahn School Of Medicine At Mount Sinai	Kinase inhibitor compounds and compositions and methods of use
US10966943B2 (en)	2018-09-06	2021-04-06	Innopharmascreen Inc.	Methods and compositions for treatment of asthma or parkinson's disease
CA3124700A1 (fr)	2018-12-31	2020-07-09	Icahn School Of Medicine At Mount Sinai	Composes inhibiteurs de kinase, compositions et procedes d'utilisation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE556587A (fr) *	1957-01-31	1957-04-11
US3169095A (en) *	1962-10-30	1965-02-09	Rexall Drug Chemical	Self-propelling powder-dispensing compositions
US4241051A (en) *	1977-11-04	1980-12-23	Christie Robert B	Calcitonin
JPS61267528A (ja) *	1984-11-26	1986-11-27	Yamanouchi Pharmaceut Co Ltd	吸収促進剤を含有するカルシトニン経鼻剤
EP0223831B1 (fr) *	1985-05-22	1992-07-15	Liposome Technology, Inc.	Procede et systeme d'inhalation de liposomes
NL8602950A (nl) *	1985-12-04	1987-07-01	Sandoz Ag	Calcitonine-derivaten en werkwijzen voor het bereiden van deze derivaten en van farmaceutische preparaten die ze bevatten.
US5059587A (en) *	1987-08-03	1991-10-22	Toyo Jozo Company, Ltd.	Physiologically active peptide composition for nasal administration

1990
- 1990-02-21 CA CA002050905A patent/CA2050905A1/fr not_active Abandoned
- 1990-02-21 FI FI913899A patent/FI913899A7/fi not_active Application Discontinuation
- 1990-02-21 JP JP90504385A patent/JPH05508616A/ja active Pending
- 1990-02-21 AU AU51949/90A patent/AU5194990A/en not_active Abandoned
- 1990-02-21 WO PCT/US1990/000928 patent/WO1990009781A1/fr not_active Ceased
- 1990-02-21 EP EP19900904101 patent/EP0460064A4/en not_active Withdrawn

Also Published As

Publication number	Publication date
AU5194990A (en)	1990-09-26
FI913899A0 (fi)	1991-08-19
FI913899A7 (fi)	1991-08-19
EP0460064A1 (fr)	1991-12-11
JPH05508616A (ja)	1993-12-02
WO1990009781A1 (fr)	1990-09-07
EP0460064A4 (en)	1992-04-01

Legal Events

Date	Code	Title	Description
1993-08-21	FZDE	Discontinued

Publication	Publication Date	Title
AU5194990A (en)	1990-09-26	Therapeutic aerosol formulations
CA2166109C (fr)	2004-12-14	Compositions pour inhalation
AU688283B2 (en)	1998-03-12	Pulmonary delivery of active fragments of parathyroid hormone
ES2218543T3 (es)	2004-11-16	Procedimiento y preparacion para la administracion de insulina por via pulmonar.
US6632456B1 (en)	2003-10-14	Compositions for inhalation
EP1107743B1 (fr)	2007-06-27	Formulations proteiques atomisees stables
US6794357B1 (en)	2004-09-21	Compositions for inhalation
CN1170527C (zh)	2004-10-13	含有甲状旁腺激素(pth)的吸入用治疗剂
US20090203576A1 (en)	2009-08-13	Methods and compositons for pulmonary delivery of insulin
JPH09315953A (ja)	1997-12-09	経鼻吸収用生理活性ペプチド組成物
WO1997007816A1 (fr)	1997-03-06	Solution contenant l'igf-i
LT3649B (en)	1996-01-25	Compositions for inhalation, method for priparing the same, using the same and inhaler
HK1009587B (en)	2002-05-03	Compositions for inhalation
KR20010006267A (ko)	2001-01-26	비강내 투여용 약제 조성물의 제조를 위한, 흡착된 단백질과 항체를 가지는 미세입자의 용도