CA2055827A1 - Solutions pour la perfusion, la preservation et la reperfusion d'organes - Google Patents

Solutions pour la perfusion, la preservation et la reperfusion d'organes

Info

Publication number: CA2055827A1
Authority: CA; Canada
Prior art keywords: solutions; perfusion; preservation; reperfusion; oxygen
Prior art date: 1990-11-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2055827A

Other languages

English (en)

Other versions

CA2055827C (fr

Inventor

Philippe Menasche

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Imtix Sangstat

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-20

Filing date

1991-11-19

Publication date

1992-05-21

1990-11-20 Priority claimed from FR9014424A external-priority patent/FR2669189B1/fr

1991-07-17 Priority claimed from FR9109027A external-priority patent/FR2679107B1/fr

1991-11-19 Application filed by Individual filed Critical Individual

1992-05-21 Publication of CA2055827A1 publication Critical patent/CA2055827A1/fr

1999-06-15 Application granted granted Critical

1999-06-15 Publication of CA2055827C publication Critical patent/CA2055827C/fr

2011-11-19 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

210000000056 organ Anatomy 0.000 title abstract 2
230000010412 perfusion Effects 0.000 title abstract 2
238000004321 preservation Methods 0.000 title abstract 2
230000010410 reperfusion Effects 0.000 title abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 2
108010024636 Glutathione Proteins 0.000 abstract 1
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
229960004308 acetylcysteine Drugs 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
230000003078 antioxidant effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960003180 glutathione Drugs 0.000 abstract 1
238000001356 surgical procedure Methods 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Environmental Sciences (AREA)
Zoology (AREA)
Dentistry (AREA)
Inorganic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

CA002055827A 1990-11-20 1991-11-19 Solutions pour la perfusion, la preservation et la reperfusion d'organes Expired - Lifetime CA2055827C (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
FR9014424A FR2669189B1 (fr)	1990-11-20	1990-11-20	Solutions de perfusion et de stockage pour transplantations cardiaques.
FR9014424		1990-11-20
FR9109027A FR2679107B1 (fr)	1991-07-17	1991-07-17	Solutions de perfusion, de conservation et de reperfusion d'organes.
FR9109027		1991-07-17

Publications (2)

Publication Number	Publication Date
CA2055827A1 true CA2055827A1 (fr)	1992-05-21
CA2055827C CA2055827C (fr)	1999-06-15

Family

ID=26228338

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002055827A Expired - Lifetime CA2055827C (fr)	1990-11-20	1991-11-19	Solutions pour la perfusion, la preservation et la reperfusion d'organes

Country Status (8)

Country	Link
AT (1)	AT399440B (fr)
BE (1)	BE1006834A3 (fr)
CA (1)	CA2055827C (fr)
CH (1)	CH683485A5 (fr)
DE (1)	DE4138040A1 (fr)
ES (1)	ES2050580B1 (fr)
GB (1)	GB2249937B (fr)
IT (1)	IT1251995B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE1007500A3 (fr) *	1992-09-18	1995-07-18	Pasteur Merieux Serums Vacc	Solution de perfusion, de conservation et de reperfusion d'organes.
EP0697169B1 (fr) *	1993-05-07	2000-11-15	Chugai Seiyaku Kabushiki Kaisha	Agent de conservation d'organes
DE4325547C2 (de) *	1993-07-29	1997-11-27	Max Planck Gesellschaft	Verwendung von Thiolverbindungen zur Therapie von Hepatitis-_Viren-induzierten Erkrankungen
JPH07215801A (ja) *	1994-01-28	1995-08-15	Senju Pharmaceut Co Ltd	肺保存剤および肺保存方法
JPH07330501A (ja) *	1994-06-14	1995-12-19	Senju Pharmaceut Co Ltd	肝保存剤および肝保存方法
DE4439477C2 (de) *	1994-11-08	1999-10-21	Asta Medica Ag	Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung der diabetischen Mikroangiopathie
DE19706111C2 (de) *	1997-02-17	1999-02-18	Fresenius Medical Care De Gmbh	Lösung zur Aufbewahrung von Organen
US5990153A (en) *	1997-05-05	1999-11-23	Wood; John G.	Ultrasonicated α-lipoic acid solutions for attenuating microvascular injury
US6045990A (en) *	1998-07-09	2000-04-04	Baust; John M.	Inclusion of apoptotic regulators in solutions for cell storage at low temperature
DE19834087C1 (de) *	1998-07-29	2000-03-30	Mirzaie Sedaposhteh Massoud	Wäßrige Konservierungslösung und Verfahren zur Aufbewahrung tierischen Gewebes
GB0028414D0 (en)	2000-11-22	2001-01-03	Univ Leeds	Flush preservation solution
DE102007026392A1 (de)	2007-06-06	2008-12-11	Bayer Healthcare Ag	Lösungen für die Perfusion und Konservierung von Organen und Geweben
GR20180100514A (el) *	2018-11-07	2020-06-15	Πανεπιστημιο Πατρων	Φαρμακευτικοι συνδυασμοι και κιτ για την προληψη ή την θεραπεια του πονου και αλλων επιπλοκων της ορθοπαιδικης ή αγγειακης χειρουργικης και του πολλαπλου τραυματος

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4186253A (en) *	1978-10-10	1980-01-29	The Green Cross Corporation	Perfusate for preserving organ to be transplanted and preserving method
US4473552A (en) *	1981-03-16	1984-09-25	Jost Leonora I	Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells
US4423600A (en) *	1982-12-10	1984-01-03	Mckenna Joan J	Method for preservation of living organic tissue by freezing
SE8403912D0 (sv) *	1984-07-30	1984-07-30	Pharmacia Ab	Lekemedelssats eller -komposition
DE3581407D1 (de) *	1985-09-06	1991-02-21	Nestle Sa	Bewahrung lebender gewebe.
US4798824A (en) *	1985-10-03	1989-01-17	Wisconsin Alumni Research Foundation	Perfusate for the preservation of organs
US4879283A (en) *	1985-10-03	1989-11-07	Wisconsin Alumni Research Foundation	Solution for the preservation of organs
ES2007994A6 (es) *	1988-08-16	1989-07-01	Grino Boira Jose Maria	Medio liquido para perfusion y preservacion de organos.
US4920044A (en) *	1988-11-08	1990-04-24	The Cleveland Clinic Foundation	Intracellular flush solution for preserving organs
US4938961A (en) *	1989-04-28	1990-07-03	Geoffrey Collins	Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia

1991
- 1991-11-05 CH CH3224/91A patent/CH683485A5/fr not_active IP Right Cessation
- 1991-11-11 IT ITMI912991A patent/IT1251995B/it active IP Right Grant
- 1991-11-18 AT AT0228791A patent/AT399440B/de not_active IP Right Cessation
- 1991-11-18 GB GB9124488A patent/GB2249937B/en not_active Expired - Lifetime
- 1991-11-18 ES ES09102549A patent/ES2050580B1/es not_active Expired - Fee Related
- 1991-11-19 CA CA002055827A patent/CA2055827C/fr not_active Expired - Lifetime
- 1991-11-19 BE BE9101067A patent/BE1006834A3/fr not_active IP Right Cessation
- 1991-11-19 DE DE4138040A patent/DE4138040A1/de not_active Withdrawn

Also Published As

Publication number	Publication date
CA2055827C (fr)	1999-06-15
GB9124488D0 (en)	1992-01-08
GB2249937A (en)	1992-05-27
ITMI912991A1 (it)	1993-05-11
ES2050580A1 (es)	1994-05-16
GB2249937B (en)	1994-02-16
IT1251995B (it)	1995-05-27
DE4138040A1 (de)	1992-05-21
ES2050580B1 (es)	1994-12-16
ATA228791A (de)	1994-10-15
ITMI912991A0 (it)	1991-11-11
CH683485A5 (fr)	1994-03-31
BE1006834A3 (fr)	1995-01-03
AT399440B (de)	1995-05-26

Legal Events

Date	Code	Title	Description
1995-11-08	EEER	Examination request
2011-11-19	MKEX	Expiry

Publication	Publication Date	Title
US7037254B2 (en)	2006-05-02	Controlled environment device
BR9909656A (pt)	2001-10-16	Método e aparelho para estabilizar tecido
CA2427765A1 (fr)	2002-05-10	Solution d'evaluation et de conservation
EP0125847A3 (fr)	1986-12-30	Procédé et appareil pour la conservation hyperbarique d'organes vivants
AU2556388A (en)	1989-04-17	Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
CA2182814A1 (fr)	1995-03-23	Cryopreservation d'equivalents tissulaires cultives
NZ219399A (en)	1989-05-29	Plasma-free platelet storage medium
WO1995002326A1 (fr)	1995-01-26	Solutions de preservation de tissus et de substitution sanguine et procedes utilisant lesdites solutions
KR890009409A (ko)	1989-08-01	기관 보존 및 저장에 적당한 조성물 및 기관 보조 방법
FR2439589A1 (fr)	1980-05-23	Systeme de sacs pour le sang multiples ayant des portions sans plastifiant et permettant un taux de survie important des composants du sang
NO913771D0 (no)	1991-09-26	Beholder for transport av levende transplantasjonsorganer.
EP0701455A4 (fr)	1998-01-07	Solution semblable au plasma
ES2178487T3 (es)	2002-12-16	Solucion de perfusion y/o de conservacion y/o de reperfusion en el transplante de organos.
IT1251995B (it)	1995-05-27	Soluzioni di perfusione,di conservazione e di riperfusione d'organi
NO982721L (no)	1998-08-14	Preserverende oppl°sning
GB2270614B (en)	1996-03-20	Solution for the perfusion, preservation and reperfusion of organs
WO2002030193A3 (fr)	2002-09-12	Solution de perfusion pour machine de perfusion destinee a la conservation d'organes et de tissus biologiques
GR3019229T3 (en)	1996-06-30	Use of protective agents against reactive oxygen species
CA2067371A1 (fr)	1992-02-07	Composition a base d'hemoglobine stable et methode de conservation de cette composition
US20160081327A1 (en)	2016-03-24	Organ and tissue preservation solutions having increased oxygen-content, stability and shelf life
US5556842A (en)	1996-09-17	Method for viable preservation of lung grafts
SE9800804D0 (sv)	1998-03-12	Storage of moist grain
JP2872720B2 (ja)	1999-03-24	肺保存方法及びその装置
JPS6440401A (en)	1989-02-10	Device for preserving organ
Wang et al.	1991	Tissue ice content and function recovery of the cardiac explant after freezing