ES2178487T3 - Solucion de perfusion y/o de conservacion y/o de reperfusion en el transplante de organos. - Google Patents

Solucion de perfusion y/o de conservacion y/o de reperfusion en el transplante de organos.

Info

Publication number
ES2178487T3
ES2178487T3 ES99954071T ES99954071T ES2178487T3 ES 2178487 T3 ES2178487 T3 ES 2178487T3 ES 99954071 T ES99954071 T ES 99954071T ES 99954071 T ES99954071 T ES 99954071T ES 2178487 T3 ES2178487 T3 ES 2178487T3
Authority
ES
Spain
Prior art keywords
perfusion
rate
conservation
organ transplantation
reperfusion solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99954071T
Other languages
English (en)
Inventor
Patrick Cozzone
Monique Bernard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of ES2178487T3 publication Critical patent/ES2178487T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Solución de perfusión y/o de conservación y/o de la reperfusión en el momento del transplante de órganos, en particular del órgano cardíaco, caracterizada porque contiene los elementos siguientes: K+ a razón de alrededor de 4 a 7 mM, en particular alrededor de 4 mM Ca2+ a razón de alrededor de 0,2 a 0,3 mM, en particular alrededor de 0,25 mM Mg2+ a razón de alrededor de 13 a 16 mM, en particular alrededor de 13 mM glutamato a razón de alrededor de 18 a 22 mM, en particular alrededor de 20 mM arginina a razón de alrededor de 2 a 4 mM, en particular alrededor de 3 mM adenosina a razón de alrededor de 0,5 a 1 mM, en particular alrededor de 0,5 mM
ES99954071T 1998-11-10 1999-11-05 Solucion de perfusion y/o de conservacion y/o de reperfusion en el transplante de organos. Expired - Lifetime ES2178487T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9814132A FR2785501B1 (fr) 1998-11-10 1998-11-10 Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes

Publications (1)

Publication Number Publication Date
ES2178487T3 true ES2178487T3 (es) 2002-12-16

Family

ID=9532576

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99954071T Expired - Lifetime ES2178487T3 (es) 1998-11-10 1999-11-05 Solucion de perfusion y/o de conservacion y/o de reperfusion en el transplante de organos.

Country Status (7)

Country Link
US (1) US6524785B1 (es)
EP (1) EP1047299B1 (es)
AT (1) ATE219326T1 (es)
DE (1) DE69901877T2 (es)
ES (1) ES2178487T3 (es)
FR (1) FR2785501B1 (es)
WO (1) WO2000027189A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
GB0028414D0 (en) 2000-11-22 2001-01-03 Univ Leeds Flush preservation solution
US20040170950A1 (en) * 2002-09-12 2004-09-02 Prien Samuel D. Organ preservation apparatus and methods
US9289003B2 (en) * 2003-07-02 2016-03-22 Chr. Hansen A/S Use of compounds involved in biosynthesis of nucleic acids as cryoprotective agents
EP1493806A1 (en) * 2003-07-02 2005-01-05 Chr. Hansen A/S Use of compounds involved in biosynthesis of nucleic acids as cryoprotective agents
US20050170019A1 (en) * 2003-10-22 2005-08-04 Fred Hutchinson Cancer Research Center Methods, compositions and devices for inducing stasis in cells
US20050136125A1 (en) * 2003-10-22 2005-06-23 Roth Mark B. Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms
JP2007509163A (ja) * 2003-10-22 2007-04-12 フレッド ハッチンソン キャンサー リサーチ センター 組織および臓器においてスタシスを誘導する方法、組成物、および装置
US20050142121A1 (en) * 2003-12-24 2005-06-30 Gold Joseph D. System for improving acceptance of tissue grafts made from embryonic stem cells
US20050153271A1 (en) * 2004-01-13 2005-07-14 Wenrich Marshall S. Organ preservation apparatus and methods
US9301519B2 (en) * 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
NZ591524A (en) * 2004-10-07 2012-09-28 Transmedics Inc Method for timing pulsatile flow of normothermic perfusate to the heart in ex-vivo organ care
US20060147429A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Facilitated cellular reconstitution of organs and tissues
US20060148080A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Methods for supporting and producing human cells and tissues in non-human mammal hosts
US20060160062A1 (en) 2005-01-14 2006-07-20 Young Lindon H Perfusion and/or preservation solution for organs
US8822535B2 (en) * 2005-04-20 2014-09-02 Fred Hutchinson Cancer Research Center Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
EP1948183B1 (en) * 2005-10-13 2013-12-18 Duke University Compositions for the treatment and prevention of heart disease and methods of using same
EP3677118A1 (en) * 2006-04-19 2020-07-08 Transmedics, Inc. Systems for ex vivo organ care
US20080145919A1 (en) * 2006-12-18 2008-06-19 Franklin Thomas D Portable organ and tissue preservation apparatus, kit and methods
CN105123670B (zh) * 2007-02-17 2018-12-14 哈佛学院董事会 用于进行组织保存的组合物以及方法
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US8420380B2 (en) * 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
CA2715634A1 (en) 2008-02-15 2009-08-27 President And Fellows Of Harvard College Blood substitute solution
US20090263780A1 (en) * 2008-04-17 2009-10-22 Yanming Wang Organ preservation fluid
WO2011002926A2 (en) 2009-07-01 2011-01-06 The General Hospital Corporation Isolated adult cells, artificial organs,rehabilitated organs, research rools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
US10575515B2 (en) * 2010-05-04 2020-03-03 The General Hospital Corporation Methods and compositions for preserving tissues and organs
EP2704560B1 (en) 2011-04-14 2022-04-06 Transmedics, Inc. Organ care solution for ex-vivo machine perfusion of donor lungs
US9119393B2 (en) * 2012-07-10 2015-09-01 Lifeline Scientific, Inc. Organ transporter with tilt and/or shock sensing
WO2015138832A1 (en) 2014-03-13 2015-09-17 The General Hospital Corporation Devices and methods to improve and assess viability of human livers
US10433539B2 (en) 2014-04-10 2019-10-08 Tevosol, Inc. Composition and solution with controlled calcium ion level, and related method and use for reperfusion
BR112016023394B1 (pt) 2014-04-10 2021-09-21 Darren Freed Composição cardioplégica e seu uso
US10076112B2 (en) 2014-06-02 2018-09-18 Transmedic, Inc. Ex vivo organ care system
CN107105640B (zh) * 2014-10-24 2021-10-12 体沃索股份有限公司 具有控制的钙离子水平的新型组合物和溶液以及用于再灌注的相关方法和用途
WO2016090498A1 (en) 2014-12-12 2016-06-16 Freed Darren Apparatus and method for organ perfusion
PL3277083T3 (pl) 2015-04-03 2025-05-26 Vivalyx Gmbh Zastosowanie kompozycji do prezerwacji narządów w celu prezerwacji narządu lub jego części
EP3347084B1 (en) 2015-09-09 2020-11-11 Transmedics, Inc. Aortic cannula for ex vivo organ care system
CA3025673A1 (en) 2016-05-30 2017-12-07 Tevosol, Inc. Apparatus and method for ex vivo lung ventilation with a varying exterior pressure
US12058996B2 (en) 2017-06-14 2024-08-13 The General Hospital Corporation High subzero cryopreservation
WO2019232268A1 (en) 2018-05-30 2019-12-05 Mustafa Korkut Uygun Cryopreservation of tissues and organs
CN111937861B (zh) * 2020-08-17 2021-10-26 南昌大学第二附属医院 一种七氟烷缺血再灌注装置及使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920044A (en) * 1988-11-08 1990-04-24 The Cleveland Clinic Foundation Intracellular flush solution for preserving organs
US5290766A (en) * 1991-02-18 1994-03-01 The National Heart Foundation Of New Zealand Cardioplegic compositions
US5407793A (en) * 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
CH686870A5 (fr) * 1992-09-18 1996-07-31 Pasteur Merieux Serums Vacc Solution de perfusion, de conservation et de reperfusion d'organes.

Also Published As

Publication number Publication date
ATE219326T1 (de) 2002-07-15
EP1047299A1 (fr) 2000-11-02
DE69901877T2 (de) 2003-01-23
WO2000027189A1 (fr) 2000-05-18
FR2785501B1 (fr) 2001-01-05
FR2785501A1 (fr) 2000-05-12
DE69901877D1 (de) 2002-07-25
EP1047299B1 (fr) 2002-06-19
US6524785B1 (en) 2003-02-25

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