CA2074484A1 - Composes stabilises d'hexahydro-5-pyrimidinamine en solution aqueuse et methode d'obtention - Google Patents

Composes stabilises d'hexahydro-5-pyrimidinamine en solution aqueuse et methode d'obtention

Info

Publication number: CA2074484A1
Authority: CA; Canada
Prior art keywords: antiseptic; composition; stabilized; composition according; hexahydro
Prior art date: 1990-11-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002074484A

Other languages

English (en)

Inventor

Edward J. Carlin

Anil K. Talwar

Steven S. Dills

Joseph M. Talmage

Eugene C. Samarco

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-26

Filing date

1991-11-01

Publication date

1992-05-27

1991-11-01 Application filed by Individual filed Critical Individual

1992-05-27 Publication of CA2074484A1 publication Critical patent/CA2074484A1/fr

Status Abandoned legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 29
BKXBSQULLDQCLC-UHFFFAOYSA-N 1,3-diazinan-5-amine Chemical class NC1CNCNC1 BKXBSQULLDQCLC-UHFFFAOYSA-N 0.000 title claims abstract description 14
239000007864 aqueous solution Substances 0.000 title abstract description 7
239000000203 mixture Substances 0.000 claims abstract description 322
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150000001875 compounds Chemical class 0.000 claims abstract description 29
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DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 claims description 75
229960004867 hexetidine Drugs 0.000 claims description 72
-1 hexahydro-5-pyrimidinamine compound Chemical class 0.000 claims description 70
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XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 claims description 11
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Birds (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Dermatology (AREA)
Oral & Maxillofacial Surgery (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)

CA002074484A 1990-11-26 1991-11-01 Composes stabilises d'hexahydro-5-pyrimidinamine en solution aqueuse et methode d'obtention Abandoned CA2074484A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US61772990A	1990-11-26	1990-11-26
US617,729		1990-11-26

Publications (1)

Publication Number	Publication Date
CA2074484A1 true CA2074484A1 (fr)	1992-05-27

Family

ID=24474821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002074484A Abandoned CA2074484A1 (fr)	1990-11-26	1991-11-01	Composes stabilises d'hexahydro-5-pyrimidinamine en solution aqueuse et methode d'obtention

Country Status (6)

Country	Link
EP (1)	EP0512104A1 (fr)
CA (1)	CA2074484A1 (fr)
MX (1)	MX9102200A (fr)
NZ (1)	NZ240695A (fr)
WO (1)	WO1992009283A1 (fr)
ZA (1)	ZA919297B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5496558A (en) *	1993-03-02	1996-03-05	Block Drug Company Inc.	Solid form xerostomia product
DK1029543T3 (da) *	1999-02-19	2003-03-10	Warner Lambert Co	Terapeutisk vandigt præparat indeholdende en hexahydro-5-pyrimidinamin-forbindelse og en polyalkoxyleret fedtalkohol
US7893223B2 (en)	2001-07-17	2011-02-22	Bracco Imaging S.P.A.	Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
ITMI20011518A1 (it) *	2001-07-17	2003-01-17	Bracco Imaging Spa	Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4666517A (en) *	1986-06-04	1987-05-19	Colgate-Palmolive Co.	Antiplaque oral composition
US4774078A (en) *	1986-10-06	1988-09-27	Colgate-Palmolive Company	Stable antiplaque dentifrice based on hexetidine, zinc ion and fluoride
US4992276A (en) *	1988-12-14	1991-02-12	Warner-Lambert Company	Antiseptic compositions containing hexahydro-5-pyrimidinamine compounds and thymol and methods for preparing same
EP0408174A1 (fr) *	1989-07-12	1991-01-16	Warner-Lambert Company	Composition antiseptique contenant des composés de hexahydro-5-pyrimidinamine
GB9008433D0 (en) *	1990-04-12	1990-06-13	Beecham Group Plc	Novel compositions
FR2661091B1 (fr) *	1990-04-18	1994-10-21	Andre Salkin	Utilisation de l'hexetidine ou de ses derives ou sels pour la preparation d'une composition pharmaceutique a usage ophtalmologique.

1991
- 1991-11-01 CA CA002074484A patent/CA2074484A1/fr not_active Abandoned
- 1991-11-01 EP EP92900692A patent/EP0512104A1/fr not_active Withdrawn
- 1991-11-01 WO PCT/US1991/008092 patent/WO1992009283A1/fr not_active Ceased
- 1991-11-22 NZ NZ240695A patent/NZ240695A/xx unknown
- 1991-11-25 ZA ZA919297A patent/ZA919297B/xx unknown
- 1991-11-25 MX MX9102200A patent/MX9102200A/es unknown

Also Published As

Publication number	Publication date
MX9102200A (es)	1992-07-08
NZ240695A (en)	1993-10-26
EP0512104A1 (fr)	1992-11-11
WO1992009283A1 (fr)	1992-06-11
ZA919297B (en)	1992-08-26

Legal Events

Date	Code	Title	Description
1995-05-01	FZDE	Dead

Publication	Publication Date	Title
AU618154B2 (en)	1991-12-12	Antiseptic compositions containing hexahydro-5-pyrimidinamine compounds and thymol and methods for preparing same
EP1072253B1 (fr)	2013-11-20	Compositions a administration orale
US4832994A (en)	1989-05-23	Anti-smoking oral composition
EP0408174A1 (fr)	1991-01-16	Composition antiseptique contenant des composés de hexahydro-5-pyrimidinamine
EP0421838B1 (fr)	1995-11-29	Méthode pour rendre visible la plaque dentaire
US6200550B1 (en)	2001-03-13	Oral care compositions comprising coenzyme Q10
US4814163A (en)	1989-03-21	Solid antitartar mouth deodorant
US6030605A (en)	2000-02-29	Breath freshening compositions and methods using them
CA1327532C (fr)	1994-03-08	Collutoire antibacterien contenant des hexanes bis-biguanide
CA2350450A1 (fr)	2000-05-25	Melange d'aromes destine au masquage du mauvais gout de composes de zinc
WO1996029047A1 (fr)	1996-09-26	Systemes a changement de couleur destines a des produits d'hygiene bucco-dentaire
BE1001658A5 (fr)	1990-01-23	Composition dentifrice antiplaque stable.
CA2526981C (fr)	2013-12-31	Composition de friandise dentaire antiplaque
WO1996037183A2 (fr)	1996-11-28	Compositions capables de masquer les sensations du gout astringent
US4980172A (en)	1990-12-25	Anti-smoking oral composition
WO2001028503A1 (fr)	2001-04-26	PRODUITS D'HYGIENE PERSONNELLE A BASE DE N-[N-(3,3-DIMETHYLBUTYL)-1-α-ASPARTYL]-L-PHENYLALANINE METHYL ESTER
WO1992009283A1 (fr)	1992-06-11	Composes d'hexahydro-5-pyrimidinamine stabilises en solution aqueuse et leurs procedes de preparation
US5795616A (en)	1998-08-18	Enhanced flavors using 2'-hydroxypropiophenone
JP3582571B2 (ja)	2004-10-27	口腔液体製剤
WO1997028805A1 (fr)	1997-08-14	Compositions therapeutiques contenant un compose hexahydro-5-pyrimidinamine et un compose morpholine-ether
CA1329131C (fr)	1994-05-03	Dentifrice coupe-faim
WO1998037859A1 (fr)	1998-09-03	Composition orale indiquee pour l'hygiene bucco-dentaire et les soins dentaires
WO1998031242A1 (fr)	1998-07-23	Utilisation de 2'-hydroxypropiophenone pour le renforcement du gout
JP2000512124A (ja)	2000-09-19	バクテリオシン抗菌剤含有チューインガム組成物
ZA200104070B (en)	2002-01-14	Flavour blend for masking unpleasant taste of zinc compounds.