CA2083683A1 - Formulation stable a base de sel d'analapril; methode de preparation et utilisation - Google Patents

Formulation stable a base de sel d'analapril; methode de preparation et utilisation

Info

Publication number: CA2083683A1
Authority: CA; Canada
Prior art keywords: formula; salt; sodium; stable formulation; analapril
Prior art date: 1991-11-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2083683A

Other languages

English (en)

Other versions

CA2083683C (fr

Inventor

Marjo Merslavic

Jozica Razen

Ales Rotar

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

KRKA dd

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-25

Filing date

1992-11-24

Publication date

1993-05-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25555813&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2083683(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-11-24 Application filed by Individual filed Critical Individual

1993-05-26 Publication of CA2083683A1 publication Critical patent/CA2083683A1/fr

2000-09-05 Application granted granted Critical

2000-09-05 Publication of CA2083683C publication Critical patent/CA2083683C/fr

2012-11-24 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical class C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 title abstract 2
238000009472 formulation Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
239000000654 additive Substances 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
150000003388 sodium compounds Chemical class 0.000 abstract 1
FTTHROYWFRGKST-BDURURIASA-M sodium;(2s)-1-[(2s)-2-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylate Chemical class [Na+].C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C([O-])=O)CC1=CC=CC=C1 FTTHROYWFRGKST-BDURURIASA-M 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Vascular Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

CA002083683A 1991-11-25 1992-11-24 Formulation stable a base de sel d'analapril; methode de preparation et utilisation Expired - Fee Related CA2083683C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
YUP-1842/91		1991-11-25
YU184291A YU48602B (sh)	1991-11-25	1991-11-25	Postupak za dobijanje stabilne formulacije soli enalaprila

Publications (2)

Publication Number	Publication Date
CA2083683A1 true CA2083683A1 (fr)	1993-05-26
CA2083683C CA2083683C (fr)	2000-09-05

Family

ID=25555813

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002083683A Expired - Fee Related CA2083683C (fr)	1991-11-25	1992-11-24	Formulation stable a base de sel d'analapril; methode de preparation et utilisation

Country Status (11)

Country	Link
US (1)	US5350582A (fr)
EP (1)	EP0545194B1 (fr)
AT (1)	ATE150650T1 (fr)
CA (1)	CA2083683C (fr)
DE (1)	DE69218557T2 (fr)
DK (1)	DK0545194T3 (fr)
ES (1)	ES2101004T3 (fr)
GR (1)	GR3023655T3 (fr)
HR (1)	HRP921482B1 (fr)
SI (1)	SI9111842A (fr)
YU (1)	YU48602B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5562921A (en) *	1994-07-15	1996-10-08	Sherman; Bernard C.	Stable solid pharmaceutical compositions containing enalapril maleate
US5573780A (en) *	1995-08-04	1996-11-12	Apotex Usa Inc.	Stable solid formulation of enalapril salt and process for preparation thereof
GB9521781D0 (en) *	1995-10-24	1996-01-03	Merck Sharp & Dohme	Therapeutic agents
RU2140261C1 (ru) *	1997-04-03	1999-10-27	Открытое акционерное общество "АЙ СИ ЭН Лексредства"	Твердая лекарственная форма на основе малеата эналаприла
ES2125198B1 (es) *	1997-05-13	1999-11-16	Vita Invest Sa	Asociacion a dosis fija de un inhibidor de la enzima convertidora de angiotensina y de un antagonista de los canales de calcio, procedimiento para su preparacion y su utilizacion para el tratamiento de enfermees cardiovasculares.
WO2000005247A1 (fr) *	1998-07-21	2000-02-03	Kaneka Corporation	Procede de cristallisation d'un sel d'acide maleique de n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-l-proline
NZ333206A (en)	1998-12-08	2000-07-28	Bernard Charles Sherman	Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor
US6637359B1 (en) *	1998-12-15	2003-10-28	Maritrans Inc.	System and method for internally fitting a new inner hull to an existing outer hull to form a rebuilt double hull vessel
US20040157911A1 (en) *	1999-08-31	2004-08-12	Spiridon Spireas	Storage-stable and bio-stable formulations of ace inhibitors, and methods for preparation thereof
US20030225124A1 (en) *	1999-08-31	2003-12-04	Spiridon Spireas	Stable formulations of ACE inhibitors, and methods for preparation thereof
US6764694B1 (en) *	1999-08-31	2004-07-20	Mutual Pharmaceutical Co., Inc.	Stable formulations of ACE inhibitors, and methods for preparation thereof
US6555551B1 (en)	1999-08-31	2003-04-29	Mutual Pharmaceutical Co., Inc.	Stable formulations of ACE inhibitors, and methods for preparation thereof
HU226950B1 (en) *	1999-11-03	2010-03-29	Richter Gedeon Nyrt	The magnesium salt of enalapril and antihypertensive pharmaceutical composition containing it
US20030215526A1 (en) *	2002-03-08	2003-11-20	Scott Stofik	Stable formulations of angiotensin converting enzyme (ACE) inhibitors
PT1729739T (pt) *	2004-03-29	2016-12-01	Servier Lab	Processo para a preparação de uma composição farmacêutica sólida
SI21800A (sl) *	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
RS53324B (sr)	2005-11-17	2014-10-31	Silverstone Pharma Est.	Stabilna formulacija amorfnih soli perindoprila, postupak za njihovu pripremu, naročito industrijsku pripremu, i njihova upotreba u terapiji hipertenzije
SI23149A (sl)	2009-09-21	2011-03-31	Silverstone Pharma	Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
EP2585051B2 (fr) †	2010-06-23	2020-04-08	KRKA, tovarna zdravil, d.d., Novo mesto	Formes pharmaceutiques à usage oral comprenant de la lercanidipine et de l'énalapril et leurs sels pharmaceutiquement acceptables
WO2012085249A2 (fr)	2010-12-24	2012-06-28	Krka, D.D., Novo Mesto	Formes pharmaceutiques orales homogènes comprenant de la lercanidipine et de l'énalapril ou leurs sels pharmaceutiquement acceptables
EP3667325B1 (fr)	2013-08-28	2023-10-04	Psychemedics Corporation	Test d'intégrité d'échantillons de cheveux
HUE041705T2 (hu)	2014-07-31	2019-05-28	Pharmathen Sa	Enalaprilt tartalmazó, szájban diszpergálódó film készítmény magas vérnyomás kezelésére gyermek populációban

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4830853A (en) *	1986-10-20	1989-05-16	Warner-Lambert Company	Drug compositions stabilized against oxidation
US4743450A (en) *	1987-02-24	1988-05-10	Warner-Lambert Company	Stabilized compositions
EP0391462A1 (fr) *	1989-04-05	1990-10-10	Janssen Pharmaceutica N.V.	Combinaisons synergiques à kétanserin

1991
- 1991-11-25 SI SI9111842A patent/SI9111842A/sl unknown
- 1991-11-25 YU YU184291A patent/YU48602B/sh unknown
1992
- 1992-11-23 DK DK92119896.6T patent/DK0545194T3/da active
- 1992-11-23 DE DE69218557T patent/DE69218557T2/de not_active Expired - Lifetime
- 1992-11-23 ES ES92119896T patent/ES2101004T3/es not_active Expired - Lifetime
- 1992-11-23 EP EP92119896A patent/EP0545194B1/fr not_active Expired - Lifetime
- 1992-11-23 AT AT92119896T patent/ATE150650T1/de not_active IP Right Cessation
- 1992-11-24 US US07/980,956 patent/US5350582A/en not_active Expired - Fee Related
- 1992-11-24 CA CA002083683A patent/CA2083683C/fr not_active Expired - Fee Related
- 1992-12-30 HR HRP-1842/91A patent/HRP921482B1/xx not_active IP Right Cessation
1997
- 1997-06-04 GR GR970401299T patent/GR3023655T3/el unknown

Also Published As

Publication number	Publication date
CA2083683C (fr)	2000-09-05
DE69218557D1 (de)	1997-04-30
YU184291A (sh)	1994-04-05
US5350582A (en)	1994-09-27
ES2101004T3 (es)	1997-07-01
DK0545194T3 (da)	1997-07-28
GR3023655T3 (en)	1997-09-30
EP0545194B1 (fr)	1997-03-26
DE69218557T2 (de)	1997-11-13
EP0545194A1 (fr)	1993-06-09
HRP921482B1 (en)	2000-04-30
SI9111842A (sl)	1998-04-30
ATE150650T1 (de)	1997-04-15
HRP921482A2 (en)	1996-12-31
YU48602B (sh)	1998-12-23

Legal Events

Date	Code	Title	Description
1996-08-09	EEER	Examination request
2002-11-25	MKLA	Lapsed

Publication	Publication Date	Title
GR3023655T3 (en)	1997-09-30	Stable formulation of enalapril salt, a process for the preparation thereof and the use thereof
TW263499B (fr)	1995-11-21
DE3460577D1 (en)	1986-10-09	Sodium salt of ursodeoxycholic sulphate
CS144791A3 (en)	1992-03-18	Novel sulfonyl compounds
IL113011A (en)	1999-09-22	R-mandelic acid salt of (2s,3s)-3- (2-methoxybenzylamino)-2- phenylpiperidine
CA2047783A1 (fr)	1992-02-10	Solution stable d'hypochlorite de sodium
ES8308864A1 (es)	1983-10-01	Procedimiento para la fabricacion de nuevos derivados aminoalcoxi aromaticos.
AU5188393A (en)	1994-06-16	15-deoxyspergualin analogs, their method of preparation and their use in therapeutics
CA2044484A1 (fr)	1991-12-15	Derives de l'hexahydroazepine, leur methode de preparation et les compositions pharmaceutiques qui les renferment
EP0138616A3 (fr)	1987-06-16	Nona- et décapeptides pour augmenter l'activité naturelle de destruction de cellules, leurs procédés d'obtention et compositions pharmaceutiques les contenant
HU901193D0 (en)	1990-05-28	Process for protection against phytopathogenic bacteria using phosphonic acid derivatives
AU565492B2 (en)	1987-09-17	4-phenyl-4-oxo-buten-2-oic acids
IL73090A0 (en)	1984-12-31	5h-(1)benzopyrano(2,3-d)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
MY110751A (en)	1999-02-27	Positive inotropic and lusitropic pyrroloquinolinone derivatives
JPS57188515A (en)	1982-11-19	Stabilized aqueous dopamine preparation
CA2076772A1 (fr)	1993-02-28	Nouvelle analogues de la vitamine d3
AU6701096A (en)	1997-02-26	Process for the manufacturing of iodinated contrast agents
ES8501380A1 (es)	1984-11-16	Un procedimiento para preparar l-tiazolidin-4-carboxilato de zinc
GR79822B (fr)	1984-10-31
EP0364928A3 (fr)	1991-07-03	Composition de pâte de dentifrice
DE69608260D1 (en)	2000-06-15	Wässrige spectinomycinborat-auflösung
ES8500266A1 (es)	1984-11-01	"procedimiento para la preparacion de nuevos acidos benzoilparabanicos"
MY101628A (en)	1991-12-31	Sulfonamide compounds and salts thereof, herbicidal compositions containing them, and process for producing them.
AU8844882A (en)	1983-03-24	Benzoxazolyloxy-phenoxy herbicidal compositions
HU0005005D0 (fr)	2001-02-28