CA2088273C - Procedes pour la formulation de composes a base de loperamide sous forme posologique orale solide - Google Patents

Procedes pour la formulation de composes a base de loperamide sous forme posologique orale solide

Info

Publication number
CA2088273C
CA2088273C CA002088273A CA2088273A CA2088273C CA 2088273 C CA2088273 C CA 2088273C CA 002088273 A CA002088273 A CA 002088273A CA 2088273 A CA2088273 A CA 2088273A CA 2088273 C CA2088273 C CA 2088273C
Authority
CA
Canada
Prior art keywords
loperamide
solid oral
dosage form
oral dosage
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002088273A
Other languages
English (en)
Other versions
CA2088273A1 (fr
Inventor
Daniel Louis Barone
Francis Bernard Chapura
Shawn Alan Denny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of CA2088273A1 publication Critical patent/CA2088273A1/fr
Application granted granted Critical
Publication of CA2088273C publication Critical patent/CA2088273C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002088273A 1990-08-09 1991-07-29 Procedes pour la formulation de composes a base de loperamide sous forme posologique orale solide Expired - Fee Related CA2088273C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56501090A 1990-08-09 1990-08-09
US565,010 1990-08-09

Publications (2)

Publication Number Publication Date
CA2088273A1 CA2088273A1 (fr) 1992-02-10
CA2088273C true CA2088273C (fr) 1996-05-14

Family

ID=24256836

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002088273A Expired - Fee Related CA2088273C (fr) 1990-08-09 1991-07-29 Procedes pour la formulation de composes a base de loperamide sous forme posologique orale solide

Country Status (9)

Country Link
EP (1) EP0542879A1 (fr)
JP (1) JPH06500104A (fr)
AU (1) AU661972B2 (fr)
CA (1) CA2088273C (fr)
FI (1) FI930536A7 (fr)
IE (1) IE912815A1 (fr)
NZ (1) NZ239308A (fr)
PT (1) PT98612A (fr)
WO (1) WO1992002223A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117834A1 (fr) * 2004-05-27 2005-12-15 Janssen Pharmaceutica N.V. Dispersions solides d'un compose medicamenteux basique et d'un polymere renfermant des groupes acides
US10508373B2 (en) 2016-05-13 2019-12-17 Nike, Inc. Embroidered article

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1332236C (fr) * 1985-10-11 1994-10-04 Lourens Wals N-oxydes d'–-–-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide
DE3906779A1 (de) * 1989-03-03 1990-09-06 Hoechst Ag Mittel gegen tierparasiten
GB8908361D0 (en) * 1989-04-13 1989-06-01 Beecham Group Plc Composition
NZ233403A (en) * 1989-04-28 1992-09-25 Mcneil Ppc Inc Simulated capsule-like medicament

Also Published As

Publication number Publication date
EP0542879A1 (fr) 1993-05-26
CA2088273A1 (fr) 1992-02-10
FI930536L (fi) 1993-02-08
AU8440091A (en) 1992-03-02
WO1992002223A1 (fr) 1992-02-20
NZ239308A (en) 1994-04-27
FI930536A0 (fi) 1993-02-08
JPH06500104A (ja) 1994-01-06
IE912815A1 (en) 1992-02-12
AU661972B2 (en) 1995-08-17
PT98612A (pt) 1992-06-30
FI930536A7 (fi) 1993-02-08

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