CA2093429A1 - Methode de biophosphorylation des composes organiques - Google Patents

Methode de biophosphorylation des composes organiques

Info

Publication number
CA2093429A1
CA2093429A1 CA002093429A CA2093429A CA2093429A1 CA 2093429 A1 CA2093429 A1 CA 2093429A1 CA 002093429 A CA002093429 A CA 002093429A CA 2093429 A CA2093429 A CA 2093429A CA 2093429 A1 CA2093429 A1 CA 2093429A1
Authority
CA
Canada
Prior art keywords
compound
phosphorylated
pct
hydroxy
macrolide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002093429A
Other languages
English (en)
Inventor
Shieh-Shung T. Chen
Brian R. Petuch
Annjia T. Hsu
Byron H. Arison
Francis Dumont
Raymond F. White
David J. Mathre
Jane T. Wu
Lydia T. So
Robert A. Reamer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/691,606 external-priority patent/US5198421A/en
Application filed by Individual filed Critical Individual
Publication of CA2093429A1 publication Critical patent/CA2093429A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65525—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring
    • C07F9/65527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002093429A 1990-10-09 1991-09-19 Methode de biophosphorylation des composes organiques Abandoned CA2093429A1 (fr)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US59450090A 1990-10-09 1990-10-09
US59421490A 1990-10-09 1990-10-09
US07/594,214 1990-10-09
US07/594,500 1990-10-09
US59589490A 1990-10-11 1990-10-11
US07/595,894 1990-10-11
US69160791A 1991-04-26 1991-04-26
US07/691,606 1991-04-26
US07/691,606 US5198421A (en) 1991-04-26 1991-04-26 Phosphorylated cyclic lipopeptide
US07/691,607 1991-04-26
US70138791A 1991-05-16 1991-05-16
US07/701,387 1991-05-16
US73596391A 1991-07-25 1991-07-25
US07/735,963 1991-07-25

Publications (1)

Publication Number Publication Date
CA2093429A1 true CA2093429A1 (fr) 1992-04-10

Family

ID=27569847

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002093429A Abandoned CA2093429A1 (fr) 1990-10-09 1991-09-19 Methode de biophosphorylation des composes organiques

Country Status (4)

Country Link
EP (1) EP0552309A1 (fr)
JP (1) JPH06502536A (fr)
CA (1) CA2093429A1 (fr)
WO (1) WO1992006992A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5493107A (en) * 1993-05-07 1996-02-20 Digicomp Research Corporation Shelf price label and product placement verification method and apparatus
ES2065290B1 (es) * 1993-07-29 1995-11-01 Consejo Superior Investigacion Utilizacion de inhibidores enzimaticos para el tratamiento de enfermedades causadas por parasitos.
DK0864653T3 (da) * 1997-03-11 2004-07-12 Aventis Pharma Inc Fremgangsmåde til fremstilling af 4-(4-(4-(hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-alfa,alfa-dimethylphenyleddikesyre og phosphorylerede derivater deraf
BR0307544A (pt) 2002-02-01 2004-12-07 Ariad Gene Therapeutics Inc Compostos contendo fósforos, componentes e composição bem como, sua utilização através de métodos de tratamentos
AU2003901812A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphates of secondary alcohols
DE102005056669A1 (de) 2005-11-28 2007-05-31 Basf Ag Fermentative Herstellung organischer Verbindungen unter Einsatz Dextrin-haltiger Medien
CA2669415A1 (fr) 2006-11-14 2008-05-22 Ariad Pharmaceuticals, Inc. Formulations orales
EP3019461A1 (fr) * 2013-08-19 2016-05-18 REG Life Sciences, LLC Production de glycérol résiduaire partiellement raffiné

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61172888A (ja) * 1985-01-29 1986-08-04 Asahi Denka Kogyo Kk 有機リン酸化合物金属塩およびこれを含有する高脂血症治療剤
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
IL94862A (en) * 1989-06-30 1994-10-07 Merck & Co Inc History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It
CA2032259A1 (fr) * 1989-12-18 1991-06-19 Wayne J. Thompson Inhibiteurs de la protease du vih utiles dans le traitement du sida

Also Published As

Publication number Publication date
WO1992006992A2 (fr) 1992-04-30
JPH06502536A (ja) 1994-03-24
EP0552309A1 (fr) 1993-07-28
WO1992006992A3 (fr) 1992-06-25

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Legal Events

Date Code Title Description
FZDE Dead