JPH06502536A - 有機化合物の新規生物学的リン酸化方法 - Google Patents

有機化合物の新規生物学的リン酸化方法

Info

Publication number
JPH06502536A
JPH06502536A JP4501234A JP50123492A JPH06502536A JP H06502536 A JPH06502536 A JP H06502536A JP 4501234 A JP4501234 A JP 4501234A JP 50123492 A JP50123492 A JP 50123492A JP H06502536 A JPH06502536 A JP H06502536A
Authority
JP
Japan
Prior art keywords
compound
phosphorylated
tables
compound according
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4501234A
Other languages
English (en)
Japanese (ja)
Inventor
チエン,シイエ−シユン・トム
ピチユツチ,ブライアン・アール
シユウ,アンジア・テイ
アリソン,バイロン・エイチ
ダモン,フランシス
ホワイト,レイモンド・エフ
マザー,デイビツド・ジエイ
リーマー,ロバート・エイ
ウー,ジエーン・テイ
ソー,リイデア・テイ
Original Assignee
メルク エンド カンパニー インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/691,606 external-priority patent/US5198421A/en
Application filed by メルク エンド カンパニー インコーポレーテッド filed Critical メルク エンド カンパニー インコーポレーテッド
Publication of JPH06502536A publication Critical patent/JPH06502536A/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/117Esters of phosphoric acids with cycloaliphatic alcohols
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533Six-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65525Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring
    • C07F9/65527Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP4501234A 1990-10-09 1991-09-19 有機化合物の新規生物学的リン酸化方法 Pending JPH06502536A (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US59421490A 1990-10-09 1990-10-09
US59450090A 1990-10-09 1990-10-09
US594,500 1990-10-09
US594,214 1990-10-09
US59589490A 1990-10-11 1990-10-11
US594,894 1990-10-11
US69160791A 1991-04-26 1991-04-26
US07/691,606 US5198421A (en) 1991-04-26 1991-04-26 Phosphorylated cyclic lipopeptide
US691,606 1991-04-26
US691,607 1991-04-26
US70138791A 1991-05-16 1991-05-16
US701,387 1991-05-16
US73596391A 1991-07-25 1991-07-25
US735,963 1991-07-25
PCT/US1991/006816 WO1992006992A2 (fr) 1990-10-09 1991-09-19 Nouveau procede pour biophosphoryler des composes organiques

Publications (1)

Publication Number Publication Date
JPH06502536A true JPH06502536A (ja) 1994-03-24

Family

ID=27569847

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4501234A Pending JPH06502536A (ja) 1990-10-09 1991-09-19 有機化合物の新規生物学的リン酸化方法

Country Status (4)

Country Link
EP (1) EP0552309A1 (fr)
JP (1) JPH06502536A (fr)
CA (1) CA2093429A1 (fr)
WO (1) WO1992006992A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005516065A (ja) * 2002-02-01 2005-06-02 アリアド ジーン セラピューティクス インコーポレイテッド リン含有化合物およびその用途
JP2016529259A (ja) * 2013-08-19 2016-09-23 アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー 部分精製された廃グリセロールの製造

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5493107A (en) * 1993-05-07 1996-02-20 Digicomp Research Corporation Shelf price label and product placement verification method and apparatus
ES2065290B1 (es) * 1993-07-29 1995-11-01 Consejo Superior Investigacion Utilizacion de inhibidores enzimaticos para el tratamiento de enfermedades causadas por parasitos.
EP0864653B1 (fr) * 1997-03-11 2004-03-03 Aventis Pharmaceuticals Inc. Procédé de production d'acide 4-(4-(4-(hydroxydiphényl)-1-piperidinyl)-1-hydroxybutyl)-alpha,alpha-dimethylphénylacétique et dérivés phosphorylés
AU2003901812A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphates of secondary alcohols
DE102005056669A1 (de) 2005-11-28 2007-05-31 Basf Ag Fermentative Herstellung organischer Verbindungen unter Einsatz Dextrin-haltiger Medien
JP2010509400A (ja) 2006-11-14 2010-03-25 アリアド・ファーマシューティカルズ・インコーポレイテッド 経口処方組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61172888A (ja) * 1985-01-29 1986-08-04 Asahi Denka Kogyo Kk 有機リン酸化合物金属塩およびこれを含有する高脂血症治療剤
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
IL94862A (en) * 1989-06-30 1994-10-07 Merck & Co Inc History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It
CA2032259A1 (fr) * 1989-12-18 1991-06-19 Wayne J. Thompson Inhibiteurs de la protease du vih utiles dans le traitement du sida

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005516065A (ja) * 2002-02-01 2005-06-02 アリアド ジーン セラピューティクス インコーポレイテッド リン含有化合物およびその用途
JP2016529259A (ja) * 2013-08-19 2016-09-23 アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー 部分精製された廃グリセロールの製造

Also Published As

Publication number Publication date
WO1992006992A3 (fr) 1992-06-25
EP0552309A1 (fr) 1993-07-28
WO1992006992A2 (fr) 1992-04-30
CA2093429A1 (fr) 1992-04-10

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