CA2099433A1 - Amelioration des signaux dans les immuno-essais faisant appel a des microparticules contenant differentes substances detectables - Google Patents

Amelioration des signaux dans les immuno-essais faisant appel a des microparticules contenant differentes substances detectables

Info

Publication number
CA2099433A1
CA2099433A1 CA2099433A CA2099433A CA2099433A1 CA 2099433 A1 CA2099433 A1 CA 2099433A1 CA 2099433 A CA2099433 A CA 2099433A CA 2099433 A CA2099433 A CA 2099433A CA 2099433 A1 CA2099433 A1 CA 2099433A1
Authority
CA
Canada
Prior art keywords
detectable substances
immunoassays
microparticles
enhancement
signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2099433A
Other languages
English (en)
Other versions
CA2099433C (fr
Inventor
Thomas Joseph Mercolino
Joanne Haller Hasskamp
Edward Charles Mcfarland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2099433A1 publication Critical patent/CA2099433A1/fr
Application granted granted Critical
Publication of CA2099433C publication Critical patent/CA2099433C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586—Liposomes, microcapsules or cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002099433A 1992-07-02 1993-06-30 Amelioration des signaux dans les immuno-essais faisant appel a des microparticules contenant differentes substances detectables Expired - Fee Related CA2099433C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/908,136 US5369036A (en) 1992-07-02 1992-07-02 Enhancement of signal in immunoassays using microparticles which contain different detectable substances
US07/908,136 1992-07-02

Publications (2)

Publication Number Publication Date
CA2099433A1 true CA2099433A1 (fr) 1994-01-03
CA2099433C CA2099433C (fr) 1999-10-12

Family

ID=25425258

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002099433A Expired - Fee Related CA2099433C (fr) 1992-07-02 1993-06-30 Amelioration des signaux dans les immuno-essais faisant appel a des microparticules contenant differentes substances detectables

Country Status (6)

Country Link
US (1) US5369036A (fr)
EP (1) EP0577092B1 (fr)
JP (2) JP2643775B2 (fr)
AU (1) AU668171B2 (fr)
CA (1) CA2099433C (fr)
DE (1) DE69329318T2 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567591A (en) * 1991-06-24 1996-10-22 Becton Dickinson And Company Amplified assay for analyte
AU6909594A (en) * 1993-05-13 1994-12-12 Becton Dickinson & Company Liposomes incorporating density media
FR2707658B1 (fr) * 1993-07-12 1995-11-24 Prolabo Sa Latex fluorescent comportant au moins deux fluorochromes, procédé d'obtention et application dudit latex comme marqueur, notamment en biologie.
GB9326379D0 (en) * 1993-12-23 1994-02-23 Sinvent As Method of assay
US5750357A (en) * 1994-05-18 1998-05-12 Microquest Diagnostics, Inc. Method of rapid analyte detection
GB9413308D0 (en) * 1994-07-01 1994-08-24 Mini Agriculture & Fisheries Microencapsulated labelling technique
US5840859A (en) * 1995-07-06 1998-11-24 Research Corporation Technologies, Inc. (Aminostyryl)pyridinium compounds for radiolabelling cell membranes
IL117605A0 (en) * 1996-03-21 1996-07-23 Markman Ofer Multi-antigen serological diagnosis
GB9801120D0 (en) * 1998-01-21 1998-03-18 Secr Defence Detection system
WO2000014545A1 (fr) * 1998-09-03 2000-03-16 Trellis Bioinformatics, Inc. Etiquettes a nuances multiples
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
US20050148101A1 (en) * 1999-01-23 2005-07-07 Bamdad Cynthia C. Interaction of colloid-immobilized species with species on non-colloidal structures
JP2002535656A (ja) * 1999-01-23 2002-10-22 ミナーヴァ・バイオテクノロジーズ・コーポレーション コロイド固定化種と非コロイド構造上の種との相互作用
WO2002001230A2 (fr) * 2000-06-23 2002-01-03 Minerva Biotechnologies Corporation Detection rapide et sensible de l'agregation des proteines
AU762944B2 (en) * 1999-06-23 2003-07-10 Cornell Research Foundation Inc. Dehydration/rehydration of marked liposomes on a test device
US6576460B1 (en) 1999-10-28 2003-06-10 Cornell Research Foundation, Inc. Filtration-detection device and method of use
AU7014001A (en) * 2000-06-23 2002-01-08 Minerva Biotechnologies Corp Interaction of colloid-immobilized species with species on non-colloidal structures
DE10042023C2 (de) * 2000-08-08 2003-04-10 Biognostic Ag Kapseln, die feste Teilchen signalerzeugender Substanzen einkapseln, und deren Verwendung bei Bioassays zum Nachweis von Zielmolekülen in einer Probe
US6797481B1 (en) 2000-10-17 2004-09-28 Dade Behring Marburg Gmbh Simultaneous screening of multiple analytes
DE60135147D1 (de) * 2000-10-17 2008-09-11 Besst Test Aps Nen biologischen zelle in einer körperflüssigkeitsprobe
JP2004511808A (ja) * 2000-10-17 2004-04-15 ベッスト−テスト　アンパーツゼルスカブ 体液サンプル中の生物学的細胞の直接的検出のためのアッセイ
ES2257446T3 (es) * 2000-10-17 2006-08-01 Besst-Test Aps Ensayo para detectar directamente un indicador de inflamacion en una muestra de fluido corporal.
RU2203495C2 (ru) * 2001-06-06 2003-04-27 Государственный научно-исследовательский институт биологического приборостроения Способ липосомального иммуноанализа для детектирования аналитов в образце
GB0129776D0 (en) * 2001-12-13 2002-01-30 Sec Dep For Environment Food & Assay device and method
WO2003064679A2 (fr) * 2002-01-30 2003-08-07 Id Biomedical Corporation Procedes pour detecter des microorganismes resistant a la vancomycine et composition pour la mise en oeuvre dudit procede
RU2213974C1 (ru) * 2002-04-09 2003-10-10 Баженов Алексей Иванович Способ одновременного определения нескольких аналитов
DE60318435T2 (de) 2002-05-31 2008-12-24 Cornell Research Foundation, Inc. Universeller biosensor und verfahren zur verwendung
US20050019954A1 (en) * 2003-07-23 2005-01-27 Eastman Kodak Company Photochromic dyes for microsphere based sensor
US7413868B2 (en) * 2003-11-05 2008-08-19 Trellis Bioscience, Inc. Use of particulate labels in bioanalyte detection methods
JP4347107B2 (ja) 2004-03-26 2009-10-21 株式会社イノアックコーポレーション 磁気的免疫反応測定のための試験容器およびその製造方法
ATE476659T1 (de) * 2004-06-09 2010-08-15 Becton Dickinson Co Sensor für mehrere analyte
KR101076578B1 (ko) 2004-06-23 2011-10-24 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물
US7507588B2 (en) * 2005-04-20 2009-03-24 Becton, Dickinson And Company Multiplex microparticle system
GB0512769D0 (en) * 2005-06-23 2005-07-27 Avacta Ltd Ratiometic multicolour fluorescence correlation screening; agents for use therewith and methods of production thereof
JP2007101339A (ja) * 2005-10-04 2007-04-19 Naoyoshi Egashira 電解発光物質を内包するリポソームによるイムノアッセイ方法
NZ569658A (en) 2006-01-19 2011-07-29 Lattec I S A novel dry stick device construction and method for determining an analyte in a sample using said dry stick device
PL1982183T3 (pl) 2006-01-19 2012-11-30 Lattec I/S Urządzenie suchego paska i sposób oznaczania analitu w próbce
HRP20140460T1 (hr) 2008-04-11 2014-06-20 Board Of Regents Of The University Of Texas System Postupak i uređaj za pojačanje elektrogenerirane kemiluminescencije nanočestica
DE102008019928A1 (de) * 2008-04-21 2009-12-31 Siemens Healthcare Diagnostics Gmbh Polyelektrolyt-Monoschichten mit kovalenten Bindungsstellen für optische Signalwandler
KR101603356B1 (ko) 2008-05-08 2016-03-14 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 전기발생 화학발광에 사용되는 발광 나노구조 물질
CN102414561A (zh) * 2009-04-28 2012-04-11 创新实验室技术公司 侧流式免疫层析测定设备
RU2497128C2 (ru) * 2011-12-30 2013-10-27 Федеральное Государственное Автономное Образовательное Учреждение Высшего Профессионального Образования "Сибирский Федеральный Университет" Способ одновременного определения двух аналитов биолюминесцентным молекулярным микроанализом
GB201705407D0 (en) 2017-04-04 2017-05-17 Imp Innovations Ltd Colour changing compositions

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5984162A (ja) * 1982-11-05 1984-05-15 Toshiba Corp 免疫分析法
DE3322373C2 (de) * 1983-05-19 1986-12-04 Ioannis Dr. 3000 Hannover Tripatzis Testmittel und Verfahren zum Nachweis von Antigenen und/oder Antikörpern
US4663277A (en) * 1983-05-20 1987-05-05 Profile Diagnostic Sciences Inc. Virus detection method and materials
US4695554A (en) * 1984-02-14 1987-09-22 Becton Dickinson And Company Sac or liposome containing dye (sulforhodamine) for immunoassay
US4703017C1 (en) * 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
GB8422512D0 (en) * 1984-09-06 1984-10-10 Wellcome Found Diagnostic test methods
US4745075A (en) * 1984-09-06 1988-05-17 Burroughs Wellcome Co. Diagnostic test methods
JPS6345563A (ja) * 1986-04-11 1988-02-26 Hitachi Ltd 細胞分析方法
US4920046A (en) * 1987-02-20 1990-04-24 Becton, Dickinson And Company Process, test device, and test kit for a rapid assay having a visible readout
US4978625A (en) * 1987-10-19 1990-12-18 Becton, Dickinson And Company Fluorescence immunoassay using water insoluble dyes
IL91414A0 (en) * 1988-08-31 1990-04-29 Zynaxis Technologies Inc Reagents and methods for the determination of analytes
GB9003593D0 (en) * 1990-02-16 1990-04-11 Pa Consulting Services Improvements in or relating to fluorescence assays
JP2683172B2 (ja) * 1991-10-01 1997-11-26 キヤノン株式会社 検体測定方法及び検体測定装置
CA2125769C (fr) * 1991-12-13 1999-01-26 Morgan Van Aken Epreuves d'agglutination et trousses a colorants colloidaux

Also Published As

Publication number Publication date
US5369036A (en) 1994-11-29
AU4144093A (en) 1994-01-06
EP0577092B1 (fr) 2000-08-30
EP0577092A2 (fr) 1994-01-05
JPH07287016A (ja) 1995-10-31
EP0577092A3 (en) 1994-09-07
CA2099433C (fr) 1999-10-12
JPH09184841A (ja) 1997-07-15
JP2643775B2 (ja) 1997-08-20
DE69329318D1 (de) 2000-10-05
DE69329318T2 (de) 2001-04-26
AU668171B2 (en) 1996-04-26

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Legal Events

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