CA2101256A1 - Methode de separation de deux solides - Google Patents

Methode de separation de deux solides

Info

Publication number: CA2101256A1
Authority: CA; Canada
Prior art keywords: catalyst; dissolved; reaction; density; enzyme
Prior art date: 1991-01-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002101256A

Other languages

English (en)

Inventor

Svend Kaasgaard

Lars G. Karlsen

Ib Schneider

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk AS

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-25

Filing date

1992-01-24

Publication date

1992-07-26

1992-01-24 Application filed by Individual filed Critical Individual

1992-07-26 Publication of CA2101256A1 publication Critical patent/CA2101256A1/fr

Status Abandoned legal-status Critical Current

Links

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NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 claims description 14
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VSDUZFOSJDMAFZ-VIFPVBQESA-N methyl L-phenylalaninate Chemical compound COC(=O)[C@@H](N)CC1=CC=CC=C1 VSDUZFOSJDMAFZ-VIFPVBQESA-N 0.000 claims description 3
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BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 claims description 3
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NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 claims description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Analytical Chemistry (AREA)
Dispersion Chemistry (AREA)
Biomedical Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Catalysts (AREA)
Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
Peptides Or Proteins (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CA002101256A 1991-01-25 1992-01-24 Methode de separation de deux solides Abandoned CA2101256A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP91610003		1991-01-25
EP91610003.5		1991-01-25

Publications (1)

Publication Number	Publication Date
CA2101256A1 true CA2101256A1 (fr)	1992-07-26

Family

ID=8208759

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002101256A Abandoned CA2101256A1 (fr)	1991-01-25	1992-01-24	Methode de separation de deux solides

Country Status (11)

Country	Link
EP (1)	EP0569462A1 (fr)
JP (1)	JPH06504947A (fr)
AU (1)	AU1235992A (fr)
BG (1)	BG97981A (fr)
CA (1)	CA2101256A1 (fr)
CZ (1)	CZ148593A3 (fr)
HU (1)	HUT67012A (fr)
MX (1)	MX9200313A (fr)
NO (1)	NO932576L (fr)
SK (1)	SK78593A3 (fr)
WO (1)	WO1992012782A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE1007296A3 (nl) *	1993-07-19	1995-05-09	Dsm Nv	Werkwijze voor de bereiding van een beta-lactamderivaat.
US6060268A (en) *	1995-07-18	2000-05-09	Gist-Brocades B.V.	Penicillin G acylase immobilized with a crosslinked mixture of gelled gelatin and amino polymer
DK0839192T3 (da) *	1995-07-18	2009-04-06	Dsm Ip Assets Bv	Et forbedret immobiliseret penicillin G-acylase
WO1998056945A1 (fr) *	1997-06-10	1998-12-17	Dsm N.V.	PROCEDE DE PREPARATION D'UNE β-LACTAMINE PAR ACTION ENZYMATIQUE ET ANTIBIOTIQUE AINSI PRODUIT
EP0997199A1 (fr) *	1998-10-26	2000-05-03	Dsm N.V.	Procédé de séparation de composés solides en suspension
JP5606693B2 (ja) *	2009-06-30	2014-10-15	株式会社カネカ	液性油成分除去方法、細胞分離方法及び細胞分離キット
EP2513327B1 (fr)	2009-12-14	2016-06-29	DSM Sinochem Pharmaceuticals Netherlands B.V.	Procédé de fabrication de la céphradine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4063017A (en) *	1976-04-22	1977-12-13	Purdue Research Foundation	Porous cellulose beads and the immobilization of enzymes therewith
JPS5411293A (en) *	1977-05-23	1979-01-27	Toyo Soda Mfg Co Ltd	Recovery of protease
FR2571498B1 (fr) *	1984-10-04	1988-04-08	Immunotech Sa	Procede de separation de cellules utilisant des anticorps et des billes de faible densite
SE465604B (sv) *	1988-11-16	1991-10-07	Alfa Laval Ab	Saett foer avskiljning av ett aemne fraan en vaetska med hjaelp av partikelformigt material

1992
- 1992-01-24 HU HU9302146A patent/HUT67012A/hu unknown
- 1992-01-24 SK SK785-93A patent/SK78593A3/sk unknown
- 1992-01-24 MX MX9200313A patent/MX9200313A/es not_active IP Right Cessation
- 1992-01-24 CA CA002101256A patent/CA2101256A1/fr not_active Abandoned
- 1992-01-24 WO PCT/DK1992/000024 patent/WO1992012782A1/fr not_active Ceased
- 1992-01-24 CZ CS931485A patent/CZ148593A3/cs unknown
- 1992-01-24 AU AU12359/92A patent/AU1235992A/en not_active Abandoned
- 1992-01-24 EP EP92904422A patent/EP0569462A1/fr not_active Ceased
- 1992-01-24 JP JP4504130A patent/JPH06504947A/ja active Pending
1993
- 1993-07-15 NO NO93932576A patent/NO932576L/no unknown
- 1993-07-22 BG BG97981A patent/BG97981A/xx unknown

Also Published As

Publication number	Publication date
AU1235992A (en)	1992-08-27
NO932576D0 (no)	1993-07-15
BG97981A (en)	1994-04-25
HU9302146D0 (en)	1993-11-29
EP0569462A1 (fr)	1993-11-18
WO1992012782A1 (fr)	1992-08-06
NO932576L (no)	1993-07-15
JPH06504947A (ja)	1994-06-09
MX9200313A (es)	1992-10-30
SK78593A3 (en)	1994-01-12
CZ148593A3 (en)	1994-01-19
HUT67012A (en)	1995-01-30

Legal Events

Date	Code	Title	Description
1998-01-26	FZDE	Discontinued

Publication	Publication Date	Title
EP2367940B1 (fr)	2017-11-22	Acylases de pénicilline G mutantes
CA2086250C (fr)	2001-05-29	Mode de preparation de beta-lactames
SK63894A3 (en)	1995-03-08	Method of preparation of beta-lactam antibiotic
US6503727B1 (en)	2003-01-07	Process for the preparation of an antibiotic
CA2101256A1 (fr)	1992-07-26	Methode de separation de deux solides
EP1831390B1 (fr)	2014-11-19	Procedé pour la synthèse du cefaclor
EP0730036B1 (fr)	2000-04-19	Procédé pour la synthèse enzymatique d'antibiotiques bèta-lactame en présence d'un inhibiteur d'enzyme
EP1416054B1 (fr)	2005-08-17	Procédé enzymatique simple pour préparer du cefazolin
EP0640014A1 (fr)	1995-03-01	Procede de separation
CN115851786B (zh)	2025-01-24	一种编码青霉素g酰化酶的基因及表达的突变后青霉素g酰化酶在制备头孢氨苄中应用
EP1487990A2 (fr)	2004-12-22	Procede de preparation d'acides beta-aminocarboxyliques optiquement actifs a partir d'acides beta-aminocarboxyliques n-acyles racemiques
CN1928102B (zh)	2011-08-10	一种拆分β-氨基酸的方法
US20040053912A1 (en)	2004-03-18	Process for the preparation of a beta -lactam nucleus and the application thereof
JP2000512860A (ja)	2000-10-03	β―ラクタム抗生物質を調製する方法
JPH08242884A (ja)	1996-09-24	ペニシリン及びセファロスポリンの酵素製造法
EP0997199A1 (fr)	2000-05-03	Procédé de séparation de composés solides en suspension
WO1998056945A1 (fr)	1998-12-17	PROCEDE DE PREPARATION D'UNE β-LACTAMINE PAR ACTION ENZYMATIQUE ET ANTIBIOTIQUE AINSI PRODUIT
Janssen	2006	Properties of immobilised penicillin G Acylase in beta-lactam antibiotic synthesis
WO2001030783A1 (fr)	2001-05-03	ELABORATION D'UNE β-LACTAMINE
WO1998048037A1 (fr)	1998-10-29	Procede de regulation de la solubilite d'une betalactamine
WO1998056944A1 (fr)	1998-12-17	COMPOSES DE SOUFRE REDUCTEURS APPLIQUES AU COURS DE LA PREPARATION ENZYMATIQUE DE COMPOSES DE β-LACTAME
HK1021205A (en)	2000-09-08	A METHOD FOR PREPARING A β-LACTAM ANTIBIOTIC