CA2106764A1 - Polypeptides substitues en ó presentant une activite therapeutique - Google Patents

Polypeptides substitues en ó presentant une activite therapeutique

Info

Publication number: CA2106764A1
Authority: CA; Canada
Prior art keywords: methyl; alpha; carbonyl; tryptophyl; phenylalaninamide
Prior art date: 1991-04-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002106764A

Other languages

English (en)

Inventor

David C. Horwell

John Hughes

Reginald S. Richardson

William Howson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-24

Filing date

1992-04-15

Publication date

1992-10-25

1992-04-15 Application filed by Individual filed Critical Individual

1992-10-25 Publication of CA2106764A1 publication Critical patent/CA2106764A1/fr

Status Abandoned legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
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- A61P25/24—Antidepressants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/66—Thymopoietins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Toxicology (AREA)
Zoology (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)

CA002106764A 1991-04-24 1992-04-15 Polypeptides substitues en ó presentant une activite therapeutique Abandoned CA2106764A1 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US852,086		1991-03-20
US69075591A	1991-04-24	1991-04-24
US690,755		1991-04-24
US85208692A	1992-03-20	1992-03-20
PCT/US1992/003119 WO1992019254A1 (fr)	1991-04-24	1992-04-15	POLYPEPTIDES α SUBSTITUES AYANT DES PROPRIETES THERAPEUTIQUES

Publications (1)

Publication Number	Publication Date
CA2106764A1 true CA2106764A1 (fr)	1992-10-25

Family

ID=27104664

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002106764A Abandoned CA2106764A1 (fr)	1991-04-24	1992-04-15	Polypeptides substitues en ó presentant une activite therapeutique

Country Status (8)

Country	Link
EP (1)	EP0668770A1 (fr)
JP (1)	JPH06507402A (fr)
AU (1)	AU1907292A (fr)
CA (1)	CA2106764A1 (fr)
IE (1)	IE921321A1 (fr)
NZ (1)	NZ242441A (fr)
PT (1)	PT100422A (fr)
WO (1)	WO1992019254A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0644769A4 (fr) *	1992-06-01	1995-08-09	Magainin Pharma	Peptides biologiquement actifs presentant des substitutions n-terminales.
AU5359694A (en) *	1992-10-19	1994-05-09	Warner-Lambert Company	Analogues of cholecystokinin (30-33) containing an alpha-substituted aminoacid
FR2700472B1 (fr)	1993-01-19	1995-02-17	Rhone Poulenc Rorer Sa	Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
AU691201B2 (en) *	1993-11-01	1998-05-14	Japat Ltd.	Endothelin receptor antagonists
US5610145A (en) *	1994-04-15	1997-03-11	Warner-Lambert Company	Tachykinin antagonists
US5554644A (en) *	1994-06-08	1996-09-10	Warner-Lambert Company	Tachykinin (NK2) antagonists
FR2735687B1 (fr) *	1995-06-21	1997-08-14	Sederma Sa	Nouvelles compositions cosmetiques amincissantes
WO1998007744A1 (fr) *	1996-08-23	1998-02-26	Sederma S.A.	Peptides synthetiques et leur utilisation dans les compositions cosmetiques ou dermopharmaceutiques
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WO2006049681A2 (fr) *	2004-08-30	2006-05-11	Bayer Pharmaceuticals Corporation	Agonistes recepteur y2 neuropeptidiques selectifs
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1992
- 1992-04-15 WO PCT/US1992/003119 patent/WO1992019254A1/fr not_active Ceased
- 1992-04-15 JP JP4511401A patent/JPH06507402A/ja active Pending
- 1992-04-15 EP EP92911434A patent/EP0668770A1/fr not_active Withdrawn
- 1992-04-15 CA CA002106764A patent/CA2106764A1/fr not_active Abandoned
- 1992-04-15 AU AU19072/92A patent/AU1907292A/en not_active Abandoned
- 1992-04-22 NZ NZ242441A patent/NZ242441A/en unknown
- 1992-04-23 PT PT100422A patent/PT100422A/pt not_active Application Discontinuation
- 1992-04-23 IE IE132192A patent/IE921321A1/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU1907292A (en)	1992-12-21
IE921321A1 (en)	1992-11-04
EP0668770A4 (fr)	1995-09-27
WO1992019254A1 (fr)	1992-11-12
EP0668770A1 (fr)	1995-08-30
NZ242441A (en)	1995-02-24
PT100422A (pt)	1993-09-30
JPH06507402A (ja)	1994-08-25

Legal Events

Date	Code	Title	Description
1995-10-15	FZDE	Dead

Publication	Publication Date	Title
US6294534B1 (en)	2001-09-25	Spiropiperidine derivatives as melanocortin receptor agonists
US5710129A (en)	1998-01-20	Inhibitors of SH2-mediated processes
US5719296A (en)	1998-02-17	Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
CA2106764A1 (fr)	1992-10-25	Polypeptides substitues en ó presentant une activite therapeutique
US5190922A (en)	1993-03-02	Terminally modified tri-, tetra- and pentapeptide anaphylatoxin receptor ligands
NO861141L (no)	1986-09-23	Fremgangsmaate ved fremstilling av therapeutisk virksomme n,n[-dialkylguanidino-dipeptider.
AU4680199A (en)	1999-12-30	Spiropiperidine derivatives as melanocortin receptor agonists
FI70228B (fi)	1986-02-28	Foerfarande foer framstaellning av en enkefalin-analog-peptid
EP0933379B1 (fr)	2006-03-22	Nouveaux derives de peptides presentant un residu de thiazolyle-alanine
KR0121793B1 (ko)	1997-11-27	L-프롤린 유도체, 이의 제조 방법 및 이를 함유하는 향정신성 생물학적 제제
ES2257328T3 (es)	2006-08-01	Diazepanes sustituidos.
IL102646A (en)	1996-05-14	Non-peptidic surrogates of the ldv sequence and pharmaceutical compositions comprising them
JPH0649718B2 (ja)	1994-06-29	多環状窒素含有構造を有する新規なペプチド誘導体
Siemion et al.	1981	To the problem of biologically active conformation of enkephalin
HU185229B (en)	1984-12-28	Process for preparing pharmaceutically active peptides and acetates thereof
US4863953A (en)	1989-09-05	[3R]-3-amino-1-hydroxy pyrrolidin-2-one and its use as a neuroprotective agent
US5494898A (en)	1996-02-27	Peptide skeletal muscle relaxants
HU190915B (en)	1986-12-28	Process for preparing new tripeptide derivatives
WO1994009031A1 (fr)	1994-04-28	Analogues de cholecystokinine (30-33) contenant un acide amine a substitution alpha
US5389645A (en)	1995-02-14	Substituted tyrosyl diamine amide compounds
CA2054627A1 (fr)	1992-08-14	Myorelaxants polypeptidiques
IE48006B1 (en)	1984-08-22	Psychopharmacological peptides
JP2001122895A (ja)	2001-05-08	新規なオピオイドペプチド誘導体
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US5276137A (en)	1994-01-04	Analgesic peptides with a trifluoronorvaline modification