CA2110575A1 - Utilisation de derives de tetrahydrobenzazepine dans le traitement de l'hypertension et de la migraine spleniques - Google Patents
Utilisation de derives de tetrahydrobenzazepine dans le traitement de l'hypertension et de la migraine spleniquesInfo
- Publication number
- CA2110575A1 CA2110575A1 CA002110575A CA2110575A CA2110575A1 CA 2110575 A1 CA2110575 A1 CA 2110575A1 CA 002110575 A CA002110575 A CA 002110575A CA 2110575 A CA2110575 A CA 2110575A CA 2110575 A1 CA2110575 A1 CA 2110575A1
- Authority
- CA
- Canada
- Prior art keywords
- tetrahydro
- benzazepine
- compound
- hydroxy
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919113379A GB9113379D0 (en) | 1991-06-21 | 1991-06-21 | Medicaments |
| GB919113377A GB9113377D0 (en) | 1991-06-21 | 1991-06-21 | Medicaments |
| GB9113379.3 | 1991-06-21 | ||
| GB9113377.7 | 1991-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2110575A1 true CA2110575A1 (fr) | 1993-01-07 |
Family
ID=26299102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002110575A Abandoned CA2110575A1 (fr) | 1991-06-21 | 1992-06-17 | Utilisation de derives de tetrahydrobenzazepine dans le traitement de l'hypertension et de la migraine spleniques |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0589973A1 (fr) |
| JP (1) | JPH06508352A (fr) |
| KR (1) | KR940701258A (fr) |
| AU (1) | AU1927992A (fr) |
| CA (1) | CA2110575A1 (fr) |
| IE (1) | IE921990A1 (fr) |
| MX (1) | MX9203012A (fr) |
| PT (1) | PT100602A (fr) |
| WO (1) | WO1993000094A2 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| CZ298398A3 (cs) * | 1996-03-25 | 1999-06-16 | Eli Lilly And Company | Farmaceutický přípravek |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| JPWO2002074746A1 (ja) * | 2001-03-16 | 2004-07-08 | 山之内製薬株式会社 | ベンゾアゼピン誘導体 |
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| EP2133340B1 (fr) | 2002-12-20 | 2013-01-16 | Glaxo Group Limited | Nouveaux dérivés de benzazépine |
| HUE028976T2 (en) | 2003-06-17 | 2017-02-28 | Arena Pharm Inc | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
| CN1805938B (zh) | 2003-06-17 | 2010-06-16 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物 |
| TW200510324A (en) * | 2003-08-11 | 2005-03-16 | Lilly Co Eli | 6-(2,2,2-trifluoroethylamino)-7-chiloro-2, 3, 4, 5-tetrahydro-1h-benzo[d]azepine as a 5-ht2c receptor agonist |
| SI1838677T1 (sl) | 2004-12-21 | 2010-01-29 | Arena Pharm Inc | Kristalne oblike (R)-8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepin hidroklorida |
| SG158168A1 (en) | 2004-12-23 | 2010-01-29 | Arena Pharm Inc | 5ht2c receptor modulator compositions and methods of use |
| EP2471779A1 (fr) | 2006-04-03 | 2012-07-04 | Arena Pharmaceuticals, Inc. | Procédé de résolution d'un mélange de (R)- et (S)-8-chloro-1-méthyl-2,3,4,5-tétrahydro-1H-3-benzazépine |
| US8299241B2 (en) | 2006-12-05 | 2012-10-30 | Arena Pharmaceuticals, Inc. | Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof |
| CN102015591B (zh) | 2008-03-04 | 2014-01-29 | 艾尼纳制药公司 | 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法 |
| US8952197B2 (en) | 2009-06-18 | 2015-02-10 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
| KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법 |
| JP2013536859A (ja) * | 2010-09-01 | 2013-09-26 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃアゴニストの非吸湿性塩 |
| KR20140091458A (ko) | 2010-09-01 | 2014-07-21 | 아레나 파마슈티칼스, 인크. | 신장 손상을 갖는 개체에 대한 로카세린의 투여 |
| EP3485878A1 (fr) | 2010-09-01 | 2019-05-22 | Arena Pharmaceuticals, Inc. | Formes posologiques à libération modifiée d'agonistes de 5-ht2c utiles pour la gestion du poids |
| AU2011296027A1 (en) * | 2010-09-01 | 2013-04-04 | Arena Pharmaceuticals, Inc. | Fast-dissolve dosage forms of 5-HT2C agonists |
| KR20130138770A (ko) | 2010-09-01 | 2013-12-19 | 아레나 파마슈티칼스, 인크. | 광학적으로 활성 산을 갖는 로르카세린의 염 |
| WO2014058441A1 (fr) | 2012-10-09 | 2014-04-17 | Arena Pharmaceuticals, Inc. | Procédé de gestion du poids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4659706A (en) * | 1985-12-20 | 1987-04-21 | Smithkline Beckman Corporation | Sulfinyl and sulfonyl substituted 3-benzazepines |
-
1992
- 1992-06-17 EP EP92912293A patent/EP0589973A1/fr not_active Withdrawn
- 1992-06-17 AU AU19279/92A patent/AU1927992A/en not_active Abandoned
- 1992-06-17 WO PCT/GB1992/001083 patent/WO1993000094A2/fr not_active Ceased
- 1992-06-17 CA CA002110575A patent/CA2110575A1/fr not_active Abandoned
- 1992-06-17 JP JP4511087A patent/JPH06508352A/ja active Pending
- 1992-06-17 PT PT100602A patent/PT100602A/pt not_active Application Discontinuation
- 1992-06-17 KR KR1019930703940A patent/KR940701258A/ko not_active Withdrawn
- 1992-06-19 MX MX9203012A patent/MX9203012A/es unknown
- 1992-07-01 IE IE199092A patent/IE921990A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993000094A3 (fr) | 1993-03-04 |
| MX9203012A (es) | 1993-07-01 |
| PT100602A (pt) | 1993-09-30 |
| KR940701258A (ko) | 1994-05-28 |
| JPH06508352A (ja) | 1994-09-22 |
| IE921990A1 (en) | 1992-12-30 |
| WO1993000094A2 (fr) | 1993-01-07 |
| EP0589973A1 (fr) | 1994-04-06 |
| AU1927992A (en) | 1993-01-25 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Dead |