CA2113568A1 - 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents - Google Patents

2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents

Info

Publication number
CA2113568A1
CA2113568A1 CA002113568A CA2113568A CA2113568A1 CA 2113568 A1 CA2113568 A1 CA 2113568A1 CA 002113568 A CA002113568 A CA 002113568A CA 2113568 A CA2113568 A CA 2113568A CA 2113568 A1 CA2113568 A1 CA 2113568A1
Authority
CA
Canada
Prior art keywords
carbons
group
alkyl
hydrogen
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002113568A
Other languages
English (en)
French (fr)
Inventor
Willard Mckowan Welch Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2113568A1 publication Critical patent/CA2113568A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002113568A 1991-07-17 1992-06-19 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents Abandoned CA2113568A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73157791A 1991-07-17 1991-07-17
US07/731,577 1991-07-17

Publications (1)

Publication Number Publication Date
CA2113568A1 true CA2113568A1 (en) 1993-02-04

Family

ID=24940103

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002113568A Abandoned CA2113568A1 (en) 1991-07-17 1992-06-19 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents

Country Status (22)

Country Link
EP (1) EP0594729A1 (2)
JP (1) JP2571904B2 (2)
KR (1) KR0165003B1 (2)
CN (1) CN1043759C (2)
AU (1) AU655840B2 (2)
BR (1) BR9206272A (2)
CA (1) CA2113568A1 (2)
CZ (1) CZ284133B6 (2)
EG (1) EG20048A (2)
FI (2) FI981956L (2)
HU (1) HUT70528A (2)
IE (1) IE922311A1 (2)
IL (1) IL102473A (2)
MX (1) MX9204190A (2)
NO (1) NO180445C (2)
NZ (1) NZ243580A (2)
PL (1) PL169884B1 (2)
PT (1) PT100689B (2)
RU (1) RU2065859C1 (2)
TW (1) TW201732B (2)
WO (1) WO1993002052A1 (2)
ZA (1) ZA925306B (2)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
US5852040A (en) * 1992-10-30 1998-12-22 Pfizer Inc. Neuroprotective 3,4-dihydro-2(1H)-quinolone compounds
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
US6978166B2 (en) 1994-10-07 2005-12-20 Saint Louis University System for use in displaying images of a body part
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
CA2220649C (en) * 1996-12-03 2007-02-13 F. Hoffmann-La Roche Ag 4-hydroxy-piperidine derivatives
EP1182193A4 (en) * 1999-04-09 2002-09-11 Mochida Pharm Co Ltd REMEDIES FOR NEUROGENIC PAIN
TWI254043B (en) * 1999-06-08 2006-05-01 Hoffmann La Roche Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
EP1235572A2 (en) 1999-10-29 2002-09-04 MERCK SHARP & DOHME LTD. Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
PL364625A1 (en) 2001-02-23 2004-12-13 Merck & Co, Inc. N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
WO2002080928A1 (en) 2001-04-03 2002-10-17 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
JP4544999B2 (ja) 2002-11-25 2010-09-15 持田製薬株式会社 ４−ヒドロキシピペリジン誘導体を有効成分とする呼吸器疾患治療剤
MXPA06003748A (es) * 2003-10-08 2006-06-14 Pfizer Compuestos de lactama condensada.
TWI409289B (zh) 2010-09-02 2013-09-21 Taiwan Union Technology Corp 由氮氧雜環化合物所製得之聚合物之穩態溶液及其製法與用途
AU2021297823A1 (en) * 2020-06-23 2023-02-16 Biohaven Therapeutics Ltd. Topical formulations of (1S)-1-phenyl-2-pyridin-2-ylethanamine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2546166B1 (fr) * 1983-05-19 1985-10-25 Synthelabo Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
KR0163355B1 (ko) * 1990-05-10 1998-12-01 알렌 제이. 스피겔 신경보호성 인돌론 및 관련 유도체

Also Published As

Publication number Publication date
PT100689A (pt) 1993-10-29
AU2322592A (en) 1993-02-23
NO180445C (no) 1997-04-23
FI981956A0 (fi) 1998-09-11
ZA925306B (en) 1994-01-17
IL102473A0 (en) 1993-01-14
AU655840B2 (en) 1995-01-12
HU9400136D0 (en) 1994-05-30
FI981956A7 (fi) 1998-09-11
FI940192L (fi) 1994-01-14
FI940192A0 (fi) 1994-01-14
JP2571904B2 (ja) 1997-01-16
IL102473A (en) 1997-07-13
KR0165003B1 (en) 1999-01-15
BR9206272A (pt) 1995-04-11
JPH06504293A (ja) 1994-05-19
MX9204190A (es) 1993-01-01
CN1043759C (zh) 1999-06-23
TW201732B (2) 1993-03-11
WO1993002052A1 (en) 1993-02-04
PT100689B (pt) 1999-06-30
EP0594729A1 (en) 1994-05-04
IE922311A1 (en) 1993-01-27
CZ284133B6 (cs) 1998-08-12
FI981956L (fi) 1998-09-11
CZ400892A3 (en) 1994-03-16
EG20048A (en) 1997-03-27
RU2065859C1 (ru) 1996-08-27
NZ243580A (en) 1994-10-26
NO940144D0 (no) 1994-01-14
NO940144L (no) 1994-01-14
HUT70528A (en) 1995-10-30
FI940192A7 (fi) 1994-01-14
NO180445B (no) 1997-01-13
CN1068566A (zh) 1993-02-03
PL169884B1 (pl) 1996-09-30

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued