CN1043759C - 用作抗缺血剂的2－(4－羟基哌啶子基)－1－烷醇的制备方法 - Google Patents

用作抗缺血剂的2－(4－羟基哌啶子基)－1－烷醇的制备方法 Download PDF

Info

Publication number
CN1043759C
CN1043759C CN92105921A CN92105921A CN1043759C CN 1043759 C CN1043759 C CN 1043759C CN 92105921 A CN92105921 A CN 92105921A CN 92105921 A CN92105921 A CN 92105921A CN 1043759 C CN1043759 C CN 1043759C
Authority
CN
China
Prior art keywords
carbon atoms
hydrogen
formula
hydroxyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN92105921A
Other languages
English (en)
Chinese (zh)
Other versions
CN1068566A (zh
Inventor
小W·M·韦尔奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CN1068566A publication Critical patent/CN1068566A/zh
Application granted granted Critical
Publication of CN1043759C publication Critical patent/CN1043759C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN92105921A 1991-07-17 1992-07-16 用作抗缺血剂的2－(4－羟基哌啶子基)－1－烷醇的制备方法 Expired - Fee Related CN1043759C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73157791A 1991-07-17 1991-07-17
US731,577 1991-07-17

Publications (2)

Publication Number Publication Date
CN1068566A CN1068566A (zh) 1993-02-03
CN1043759C true CN1043759C (zh) 1999-06-23

Family

ID=24940103

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92105921A Expired - Fee Related CN1043759C (zh) 1991-07-17 1992-07-16 用作抗缺血剂的2－(4－羟基哌啶子基)－1－烷醇的制备方法

Country Status (22)

Country Link
EP (1) EP0594729A1 (2)
JP (1) JP2571904B2 (2)
KR (1) KR0165003B1 (2)
CN (1) CN1043759C (2)
AU (1) AU655840B2 (2)
BR (1) BR9206272A (2)
CA (1) CA2113568A1 (2)
CZ (1) CZ284133B6 (2)
EG (1) EG20048A (2)
FI (2) FI981956L (2)
HU (1) HUT70528A (2)
IE (1) IE922311A1 (2)
IL (1) IL102473A (2)
MX (1) MX9204190A (2)
NO (1) NO180445C (2)
NZ (1) NZ243580A (2)
PL (1) PL169884B1 (2)
PT (1) PT100689B (2)
RU (1) RU2065859C1 (2)
TW (1) TW201732B (2)
WO (1) WO1993002052A1 (2)
ZA (1) ZA925306B (2)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
PL173618B1 (pl) * 1992-10-30 1998-04-30 Pfizer Związki 6-[2-(4-hydroksy-4-fenylopiperydyno)-1-hydroksypropylo]-3,4-dihydro-2(1H)-chinolonowe
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
US6978166B2 (en) 1994-10-07 2005-12-20 Saint Louis University System for use in displaying images of a body part
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
CA2220649C (en) * 1996-12-03 2007-02-13 F. Hoffmann-La Roche Ag 4-hydroxy-piperidine derivatives
CA2369695A1 (en) * 1999-04-09 2000-10-19 Manabu Itoh Agent for treating neuropathic pain
TWI254043B (en) * 1999-06-08 2006-05-01 Hoffmann La Roche Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
AU1153601A (en) 1999-10-29 2001-05-08 Merck Sharp & Dohme Limited Method to treat pain utilizing benzimidazole NMDA NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
MXPA03007621A (es) 2001-02-23 2003-12-04 Merck & Co Inc Antagonistas nr2b de n-metil-d-aspartato no arilheterociclicos n-sustituidos.
EP1390034A4 (en) 2001-04-03 2005-07-13 Merck & Co Inc N-SUBSTITUTED NONARYL HETEROCYCLO AMIDYL-NMDA / NR2B ANTAGONISTS
US7494987B2 (en) 2002-11-25 2009-02-24 Mochida Pharmaceutical Co., Ltd. Agent for treating respiratory diseases containing 4-hydroxypiperidine derivative as active ingredient
MXPA06003748A (es) * 2003-10-08 2006-06-14 Pfizer Compuestos de lactama condensada.
TWI409289B (zh) 2010-09-02 2013-09-21 Taiwan Union Technology Corp 由氮氧雜環化合物所製得之聚合物之穩態溶液及其製法與用途
BR112022025900A2 (pt) * 2020-06-23 2023-01-10 Biohaven Therapeutics Ltd Formulações tópicas de (1s)-1-fenil-2-piridin-2-iletanamina

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2071094A (en) * 1980-03-06 1981-09-16 Otsuka Pharma Co Ltd Carbostyril derivatives processes for their production andpharmaceutical composition containing them
EP0351282A1 (fr) * 1988-07-12 1990-01-17 Synthelabo Dérivés de (hydroxy-1 pipéridinyl-2 alkyl)indolones-2, quinoléinones-2, benzo[b]azépinones-2, benzimidazolones-2 et quinazolinones-2, leur préparation et leur application en thérapeutique
EP0398578A2 (en) * 1989-05-17 1990-11-22 Pfizer Inc. 2-piperidino-1-alkanol derivatives as antiischemic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2546166B1 (fr) * 1983-05-19 1985-10-25 Synthelabo Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
EP0554247B1 (en) * 1990-05-10 2000-04-26 Pfizer Inc. Neuroprotective indolone and related derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2071094A (en) * 1980-03-06 1981-09-16 Otsuka Pharma Co Ltd Carbostyril derivatives processes for their production andpharmaceutical composition containing them
EP0351282A1 (fr) * 1988-07-12 1990-01-17 Synthelabo Dérivés de (hydroxy-1 pipéridinyl-2 alkyl)indolones-2, quinoléinones-2, benzo[b]azépinones-2, benzimidazolones-2 et quinazolinones-2, leur préparation et leur application en thérapeutique
EP0398578A2 (en) * 1989-05-17 1990-11-22 Pfizer Inc. 2-piperidino-1-alkanol derivatives as antiischemic agents

Also Published As

Publication number Publication date
FI940192A0 (fi) 1994-01-14
NZ243580A (en) 1994-10-26
CN1068566A (zh) 1993-02-03
NO180445B (no) 1997-01-13
JP2571904B2 (ja) 1997-01-16
RU2065859C1 (ru) 1996-08-27
PT100689A (pt) 1993-10-29
EP0594729A1 (en) 1994-05-04
IL102473A (en) 1997-07-13
NO180445C (no) 1997-04-23
JPH06504293A (ja) 1994-05-19
EG20048A (en) 1997-03-27
CZ284133B6 (cs) 1998-08-12
BR9206272A (pt) 1995-04-11
IE922311A1 (en) 1993-01-27
NO940144D0 (no) 1994-01-14
ZA925306B (en) 1994-01-17
FI981956A0 (fi) 1998-09-11
CZ400892A3 (en) 1994-03-16
FI940192L (fi) 1994-01-14
IL102473A0 (en) 1993-01-14
PT100689B (pt) 1999-06-30
FI981956A7 (fi) 1998-09-11
TW201732B (2) 1993-03-11
CA2113568A1 (en) 1993-02-04
MX9204190A (es) 1993-01-01
KR0165003B1 (en) 1999-01-15
FI981956L (fi) 1998-09-11
WO1993002052A1 (en) 1993-02-04
FI940192A7 (fi) 1994-01-14
HUT70528A (en) 1995-10-30
AU655840B2 (en) 1995-01-12
PL169884B1 (pl) 1996-09-30
AU2322592A (en) 1993-02-23
NO940144L (no) 1994-01-14
HU9400136D0 (en) 1994-05-30

Similar Documents

Publication Publication Date Title
CN1068566A (zh) 用作抗缺血剂的2-(4-羟基哌啶子基)-1-烷醇
KR910001042B1 (ko) 4-아미노알킬-2(3h)-인돌론 및 이의 제조방법
US20180305334A1 (en) Compounds, compositions and methods of use against stress granules
EP0464604B1 (en) 1-Indolylalkyl-4-(alkoxy-pyrimidinyl)piperazines
EA007225B1 (ru) Производные n-[фенил(пиперидин-2-ил)метил]бензамида и их применение в терапии
CN1708495A (zh) 杂环化合物及以其为有效成分的抗肿瘤药
WO2003014113A1 (en) Novel benzopyran compounds and process for their preparation and use
JPS63107970A (ja) チオラクタム−ｎ−酢酸誘導体
NZ239267A (en) 3-substituted piperidine derivatives and pharmaceutical compositions
EA005117B1 (ru) Производные 3-азабицикло(3.1.0)гексана, обладающие сродством к опиодному рецептору
JP2023503465A (ja) ベータ－グルコセレブロシダーゼの活性の変質に関連する状態におけるヘテロアリール化合物およびその治療的使用
WO1990013539A1 (fr) Nouveaux derives de piperazine a substitution n et medicament de traitement des troubles fonctionnels du cerveau
ES2866324T3 (es) Derivados de 1-(1-hidroxi-2,3-dihidro-1H-inden5-il)-urea y compuestos similares como activadores del canal KCNQ2-5 para el tratamiento de la disuria
CN1304929A (zh) 4－羟基－4－苯基哌啶衍生物及含此衍生物的药物
US10851112B2 (en) Anti-HCMV virus compound
JPH08503922A (ja) ２，３−ジヒドロー２，２，４，６，７−ペンタアルキル−５−ベンゾフラノールの新規な誘導体類
EA025216B1 (ru) Производное 5-замещенной индол-3-карбоновой кислоты, обладающее противовирусным действием в отношении вируса гриппа а
JP2001521935A (ja) ３−アミノアルキルアミノ−２ｈ−１，４−ベンゾキシアジン及び３−アミノアルキルアミノ−２ｈ−１，４−ベンゾチアジン：ドーパミン受容体サブタイプ特定の配位子
KR100235506B1 (ko) 5-아미노-5,6,7,8-테트라하이드로퀴놀린 및 관련화합물,이의 제조방법 및 약제로서의 이의 용도
JP4336299B2 (ja) ５−リポキシゲナーゼ阻害活性を有する６−アルキルアミノ−２，２’−二重置換−７，８−二重置換−２ｈ−１−ベンゾピラン誘導体
US6432946B1 (en) 3-aminoalkylamino-2H-1,4-benzoxazines and 3-aminoalkylamino-2H-1,4-benzothiazines: dopamine receptor subtype specific ligands
CN101142203A (zh) 用作离子通道开放剂的新香豆素衍生物
US6255322B1 (en) 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
EP0401779B1 (en) 4,5,5a,6-Tetrahydro-3H-isoxazolo (5,4,3-kl)acridines derivatives, a process for their preparation and their use as medicaments
JPS6157582A (ja) 新規なベンゾジアゼピン類

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee