CA2118938A1 - Recepteur a gaba-a avec sites de fixation pour steroides - Google Patents

Recepteur a gaba-a avec sites de fixation pour steroides

Info

Publication number: CA2118938A1
Authority: CA; Canada
Prior art keywords: gnr; dhp; binding; grc; receptor
Prior art date: 1991-09-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002118938A

Other languages

English (en)

Inventor

Kelvin W. Gee

Nancy T. Lan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cocensys Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-13

Filing date

1992-09-09

Publication date

1993-04-01

1992-09-09 Application filed by Individual filed Critical Individual

1993-04-01 Publication of CA2118938A1 publication Critical patent/CA2118938A1/fr

Status Abandoned legal-status Critical Current

Links

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239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
238000010998 test method Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
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GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Immunology (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)

CA002118938A 1991-09-13 1992-09-09 Recepteur a gaba-a avec sites de fixation pour steroides Abandoned CA2118938A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75951291A	1991-09-13	1991-09-13
US759,512		1991-09-13

Publications (1)

Publication Number	Publication Date
CA2118938A1 true CA2118938A1 (fr)	1993-04-01

Family

ID=25055930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002118938A Abandoned CA2118938A1 (fr)	1991-09-13	1992-09-09	Recepteur a gaba-a avec sites de fixation pour steroides

Country Status (5)

Country	Link
EP (1)	EP0603312A4 (fr)
JP (1)	JPH06510999A (fr)
AU (1)	AU2657292A (fr)
CA (1)	CA2118938A1 (fr)
WO (1)	WO1993005786A1 (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
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DE69435286D1 (de) *	1993-05-24	2010-05-20	Purdue Pharma Ltd	Verfahren und zusammensetzungen zum hervorrufen von schlaf
ES2296594T3 (es) *	1994-02-14	2008-05-01	Euro-Celtique S.A.	Androstanos y pregnanos para la modulacion alosterica del receptor de gaba.
US5939545A (en) *	1994-02-14	1999-08-17	Cocensys, Inc.	Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
NZ298567A (en) *	1994-11-23	2000-01-28	Cocensys Inc	Androstane and pregnane derivatives, pharmaceutical compositions and methods of treatment
US5888996A (en) *	1995-07-26	1999-03-30	Trustees Of Boston University	Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
EP0840612A1 (fr) *	1995-07-24	1998-05-13	Trustees Of Boston University	Inhibition de l'activite des recepteurs du n-methyl-d-aspartate au moyen de derives de sulfate de pregnenolone
EP0980384A1 (fr) *	1997-05-02	2000-02-23	American Home Products Corporation	Pregnan 3,20 diol mono- et di-sulfates
AR031473A1 (es) *	2000-11-20	2003-09-24	Lundbeck & Co As H	Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide
EP2316468A1 (fr)	2002-02-22	2011-05-04	Shire LLC	Système de distribution et méthodes de protection et d'administration de dextroamphetamine
EP2275095A3 (fr)	2005-08-26	2011-08-17	Braincells, Inc.	Neurogenese par modulation des recepteurs muscariniques
EP2258358A3 (fr)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenèse avec un inhibiteur de l'acetylcholinestérase
EP1940389A2 (fr)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation de la neurogenese par inhibition de la pde
AU2006308889A1 (en)	2005-10-31	2007-05-10	Braincells, Inc.	GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2382975A3 (fr)	2006-05-09	2012-02-29	Braincells, Inc.	Neurogénèse par modulation d'angiotensine
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
WO2010099217A1 (fr)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
EP3572417B1 (fr)	2011-10-14	2025-12-17	Sage Therapeutics, LLC	Composés de 19-nor prégnane disubstitués 3,3, compositions et leurs utilisations
EP2806877B2 (fr)	2012-01-23	2025-01-29	Sage Therapeutics, Inc.	Formulations de stéroïdes neuroactifs comprenant un complexe d'allopregnanolone et de sulfobutyl ether beta-cyclodextrine
CA2882708A1 (fr)	2012-08-21	2014-02-27	Sage Therapeutics, Inc.	Procedes de traitement de l'epilepsie ou d'un etat de mal epileptique
US20160068563A1 (en)	2013-04-17	2016-03-10	Boyd L. Harrison	19-nor neuroactive steroids and methods of use thereof
KR102396328B1 (ko)	2013-04-17	2022-05-10	세이지 테라퓨틱스, 인크.	19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
US9725481B2 (en)	2013-04-17	2017-08-08	Sage Therapeutics, Inc.	19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
EP2986624B1 (fr)	2013-04-17	2020-03-25	Sage Therapeutics, Inc.	Stéroïdes neuroactifs 19-nor et pour l'utilisation thérapeutique
SI3021852T1 (sl)	2013-07-19	2021-07-30	Sage Therapeutics, Inc.	Nevroaktivni steroidi, sestavki in uporabe le-teh
AU2014308621C1 (en)	2013-08-23	2022-01-06	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
US10246482B2 (en)	2014-06-18	2019-04-02	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar)	2014-09-08	2017-06-16	Sage Therapeutics Inc	سترويدات وتركيبات نشطة عصبياً، واستخداماتها
ME03809B (fr)	2014-10-16	2021-04-20	Sage Therapeutics Inc	Compositions et méthodes pour traiter des troubles du snc
CN117024501A (zh)	2014-10-16	2023-11-10	萨奇治疗股份有限公司	靶向cns障碍的组合物和方法
WO2016082789A1 (fr)	2014-11-27	2016-06-02	Sage Therapeutics, Inc.	Compositions et procédés pour traiter des troubles du snc
RS61530B1 (sr)	2015-01-26	2021-04-29	Sage Therapeutics Inc	Kompozicije i postupci za lečenje poremećaja cns
EP4155314A1 (fr)	2015-02-20	2023-03-29	Sage Therapeutics, Inc.	Stéroïdes neuroactifs, compositions et leurs utilisations
KR20240157128A (ko)	2016-03-08	2024-10-31	세이지 테라퓨틱스, 인크.	신경활성 스테로이드, 조성물, 및 그의 용도
WO2018013615A1 (fr)	2016-07-11	2018-01-18	Sage Therapeutics, Inc.	Stéroïdes neuroactifs substitués en c7, c12 et c16 et méthodes d'utilisation associées
MA45599A (fr)	2016-07-11	2019-05-15	Sage Therapeutics Inc	Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
SG11202112391UA (en)	2019-05-31	2021-12-30	Sage Therapeutics Inc	Neuroactive steroids and compositions thereof

1992
- 1992-09-09 EP EP92920306A patent/EP0603312A4/fr not_active Withdrawn
- 1992-09-09 AU AU26572/92A patent/AU2657292A/en not_active Abandoned
- 1992-09-09 WO PCT/US1992/007613 patent/WO1993005786A1/fr not_active Ceased
- 1992-09-09 JP JP5506095A patent/JPH06510999A/ja active Pending
- 1992-09-09 CA CA002118938A patent/CA2118938A1/fr not_active Abandoned

Also Published As

Publication number	Publication date
EP0603312A4 (fr)	1995-06-07
EP0603312A1 (fr)	1994-06-29
WO1993005786A1 (fr)	1993-04-01
JPH06510999A (ja)	1994-12-08
AU2657292A (en)	1993-04-27

Legal Events

Date	Code	Title	Description
1996-03-09	FZDE	Dead

Publication	Publication Date	Title
CA2118938A1 (fr)	1993-04-01	Recepteur a gaba-a avec sites de fixation pour steroides
Lambert et al.	1996	Neurosteroid modulation of native and recombinant GABAA receptors
Fisher	2009	The anti-convulsant stiripentol acts directly on the GABAA receptor as a positive allosteric modulator
Paul et al.	1992	Neuroactive steroids
Belelli et al.	1990	Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex
Lan et al.	1991	Differential responses of expressed recombinant human γ‐aminobutyric acidA receptors to neurosteroids
Belelli et al.	1989	Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one
Gee	1988	Steroid modulation of the GABA/benzodiazepine receptor-linked chloride lonophore
Hamon et al.	2003	The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit
Losel et al.	2003	Nongenomic steroid action: controversies, questions, and answers
Majewska et al.	1990	The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor
Melchior et al.	1994	Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze
Chaki et al.	1999	Binding characteristics of [3H] DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors
Martinez Botella et al.	2015	Neuroactive steroids. 1. Positive allosteric modulators of the (γ-aminobutyric acid) A receptor: Structure–activity relationships of heterocyclic substitution at C-21
Lopez et al.	1989	Interaction of caffeine with the GABAA receptor complex: alterations in receptor function but not ligand binding
Ziolkowski et al.	2021	A neuroactive steroid with a therapeutically interesting constellation of actions at GABAA and NMDA receptors
Krishnan et al.	2012	Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors
JPH03500049A (ja)	1991-01-10	ストレス、不安および発作活性の緩和のための組成物および方法
Lambert et al.	1999	The selective interaction of neurosteroids with the GABAA receptor
Rybczynski et al.	1999	γ-Aminobutyrate-A Receptor Modulation by 3-Aryl-1-(arylsulfonyl)-1, 4, 5, 6-tetrahydropyridazines
Bell-Horner et al.	2000	Influence of subunit configuration on the interaction of picrotoxin-site ligands with recombinant GABAA receptors
Drugan et al.	1993	Decreased forebrain [35S] TBPS binding and increased [3H] muscimol binding in rats that do not develop stress-induced behavioral depression
Hawkinson et al.	1998	Substituted 3β-phenylethynyl derivatives of 3α-hydroxy-5α-pregnan-20-one: remarkably potent neuroactive steroid modulators of γ-aminobutyric acidA receptors
McAuley et al.	1993	Modulation of [3H] flunitrazepam binding by natural and synthetic progestational agents
Itier et al.	1996	Zolpidem functionally discriminates subtypes of native GABAA receptors in acutely dissociated rat striatal and cerebellar neurons