CA2148003A1 - Antimicrobial 5-hydrazino-quinolone derivatives - Google Patents
Antimicrobial 5-hydrazino-quinolone derivativesInfo
- Publication number
- CA2148003A1 CA2148003A1 CA002148003A CA2148003A CA2148003A1 CA 2148003 A1 CA2148003 A1 CA 2148003A1 CA 002148003 A CA002148003 A CA 002148003A CA 2148003 A CA2148003 A CA 2148003A CA 2148003 A1 CA2148003 A1 CA 2148003A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- ring
- heterocyclic ring
- hydrogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96896092A | 1992-10-30 | 1992-10-30 | |
| US968,960 | 1992-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2148003A1 true CA2148003A1 (en) | 1994-05-11 |
Family
ID=25514997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002148003A Abandoned CA2148003A1 (en) | 1992-10-30 | 1993-10-22 | Antimicrobial 5-hydrazino-quinolone derivatives |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0666853A1 (pt) |
| JP (1) | JPH08502750A (pt) |
| KR (1) | KR950704301A (pt) |
| CN (1) | CN1064357C (pt) |
| AU (1) | AU687018B2 (pt) |
| BR (1) | BR9307347A (pt) |
| CA (1) | CA2148003A1 (pt) |
| CZ (1) | CZ282581B6 (pt) |
| EG (1) | EG20543A (pt) |
| FI (1) | FI952049A7 (pt) |
| HU (1) | HUT72072A (pt) |
| IL (1) | IL107323A (pt) |
| MX (1) | MX9306814A (pt) |
| NO (1) | NO951640L (pt) |
| NZ (1) | NZ257470A (pt) |
| PL (1) | PL178094B1 (pt) |
| RU (1) | RU2126000C1 (pt) |
| SG (1) | SG59979A1 (pt) |
| SK (1) | SK54795A3 (pt) |
| WO (1) | WO1994010163A1 (pt) |
| ZA (1) | ZA938089B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5646163A (en) * | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
| CA2196539C (en) * | 1994-08-02 | 2001-05-15 | The Procter & Gamble Company | Process for making quinolonyl lactam antimicrobials and novel intermediate compounds |
| WO1996004247A1 (en) * | 1994-08-02 | 1996-02-15 | The Procter & Gamble Company | Process for making antimicrobial compounds |
| ATE229950T1 (de) * | 1996-02-09 | 2003-01-15 | Toyama Chemical Co Ltd | Chinolin carbonsaure-derivate und ihre salze |
| RU2248199C1 (ru) * | 2003-06-02 | 2005-03-20 | Открытое Акционерное Общество "Акционерное Курганское общество медицинских препаратов и изделий "Синтез" (ОАО "Синтез") | Глазные капли и способ их получения |
| RU2265437C2 (ru) * | 2003-07-02 | 2005-12-10 | Суханов Александр Владимирович | Способ лечения заболеваний желудка и двенадцатиперстной кишки, вызванных helicobacter pylori |
| RU2245134C1 (ru) * | 2003-09-02 | 2005-01-27 | Открытое акционерное общество "Красфарма" | Состав офлоксацина для инъекций |
| WO2005026147A1 (ja) | 2003-09-10 | 2005-03-24 | Kyorin Pharmaceutical Co., Ltd. | ７−（４−置換−３−シクロプロピルアミノメチル−１−ピロリジニル）キノロンカルボン酸誘導体 |
| US8546423B2 (en) | 2005-05-18 | 2013-10-01 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| EP2594272B1 (en) * | 2005-05-18 | 2018-07-11 | Horizon Orphan LLC | Aerosolized fluoroquinolones and uses thereof |
| CA2528849C (en) | 2005-06-08 | 2014-01-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives as antibacterial agents |
| EA010601B1 (ru) * | 2005-06-09 | 2008-10-30 | Янссен Фармацевтика Н.В. | Производные хинолина в качестве антибактериальных агентов |
| CN101020647B (zh) * | 2007-02-14 | 2011-03-30 | 杭州师范学院 | 一种β-环丙胺基丙烯酸(酯)的合成方法 |
| JP5363350B2 (ja) * | 2007-03-19 | 2013-12-11 | 武田薬品工業株式会社 | Ｍａｐｋ／ｅｒｋキナーゼ阻害剤 |
| US7928100B2 (en) * | 2007-10-05 | 2011-04-19 | Cylene Pharmaceuticals, Inc. | Quinolone analogs and methods related thereto |
| MX2010012855A (es) * | 2008-06-03 | 2010-12-21 | Actelion Pharmaceuticals Ltd | Derivados de [4-(1-amino-etil)-ciclohexil]-metil-amina y [6-(1-amino-etil)-tetrahidro-piran-3-il]-metil-amina como antibacterianos. |
| KR101959873B1 (ko) | 2008-10-07 | 2019-03-19 | 랩터 파마슈티컬스 인코포레이티드 | 약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형 |
| CA2739893C (en) | 2008-10-07 | 2016-10-04 | Mpex Pharmaceuticals, Inc. | Inhalation of levofloxacin for reducing lung inflammation |
| AR076222A1 (es) * | 2009-04-09 | 2011-05-26 | Actelion Pharmaceuticals Ltd | Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen |
| WO2011029059A1 (en) | 2009-09-04 | 2011-03-10 | Mpex Pharmaceuticals, Inc. | Use of aerosolized levofloxacin for treating cystic fibrosis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668680A (en) * | 1985-12-12 | 1987-05-26 | Warner-Lambert Company | 5-amino-6,8-difluoroquinolones as antibacterial agents |
| JPH0228178A (ja) * | 1988-04-23 | 1990-01-30 | Toyama Chem Co Ltd | 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法 |
| DE3906365A1 (de) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| WO1991002526A1 (en) * | 1989-08-16 | 1991-03-07 | Pfizer Inc. | Azabicyclo quinolone carboxylic acids |
| ES2147721T3 (es) * | 1990-04-18 | 2000-10-01 | Procter & Gamble Pharma | Quinolonil lactamas antimicrobianas. |
| DK0559774T3 (da) * | 1990-11-30 | 2000-01-31 | Warner Lambert Co | Individuelle stereoisomerer af 7-/3-(1-aminoalkyl)-1-pyrrolidinal/-quinoloner og naphthyridoner som antibakterielle midler |
-
1993
- 1993-01-30 EG EG68693A patent/EG20543A/xx active
- 1993-10-19 IL IL10732393A patent/IL107323A/xx not_active IP Right Cessation
- 1993-10-22 JP JP6511167A patent/JPH08502750A/ja active Pending
- 1993-10-22 SG SG1996007851A patent/SG59979A1/en unknown
- 1993-10-22 FI FI952049A patent/FI952049A7/fi unknown
- 1993-10-22 NZ NZ257470A patent/NZ257470A/xx unknown
- 1993-10-22 RU RU95110762A patent/RU2126000C1/ru active
- 1993-10-22 CZ CZ951097A patent/CZ282581B6/cs not_active IP Right Cessation
- 1993-10-22 SK SK547-95A patent/SK54795A3/sk unknown
- 1993-10-22 EP EP93924393A patent/EP0666853A1/en not_active Withdrawn
- 1993-10-22 BR BR9307347A patent/BR9307347A/pt not_active Application Discontinuation
- 1993-10-22 WO PCT/US1993/010091 patent/WO1994010163A1/en not_active Ceased
- 1993-10-22 CA CA002148003A patent/CA2148003A1/en not_active Abandoned
- 1993-10-22 PL PL93308671A patent/PL178094B1/pl unknown
- 1993-10-22 HU HU9501237A patent/HUT72072A/hu unknown
- 1993-10-22 KR KR1019950701690A patent/KR950704301A/ko not_active Abandoned
- 1993-10-22 AU AU54097/94A patent/AU687018B2/en not_active Ceased
- 1993-10-29 ZA ZA938089A patent/ZA938089B/xx unknown
- 1993-10-29 MX MX9306814A patent/MX9306814A/es not_active IP Right Cessation
- 1993-10-30 CN CN93120224A patent/CN1064357C/zh not_active Expired - Fee Related
-
1995
- 1995-04-28 NO NO951640A patent/NO951640L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL107323A0 (en) | 1994-01-25 |
| WO1994010163A1 (en) | 1994-05-11 |
| HU9501237D0 (en) | 1995-06-28 |
| MX9306814A (es) | 1994-07-29 |
| AU5409794A (en) | 1994-05-24 |
| BR9307347A (pt) | 1999-05-25 |
| NO951640L (no) | 1995-06-30 |
| PL308671A1 (en) | 1995-08-21 |
| RU2126000C1 (ru) | 1999-02-10 |
| AU687018B2 (en) | 1998-02-19 |
| CN1064357C (zh) | 2001-04-11 |
| CN1092773A (zh) | 1994-09-28 |
| IL107323A (en) | 2000-06-01 |
| SG59979A1 (en) | 1999-02-22 |
| CZ109795A3 (en) | 1995-12-13 |
| ZA938089B (en) | 1994-06-07 |
| JPH08502750A (ja) | 1996-03-26 |
| EG20543A (en) | 1999-07-31 |
| RU95110762A (ru) | 1997-01-10 |
| NO951640D0 (no) | 1995-04-28 |
| FI952049A0 (fi) | 1995-04-28 |
| EP0666853A1 (en) | 1995-08-16 |
| PL178094B1 (pl) | 2000-02-29 |
| NZ257470A (en) | 1997-08-22 |
| HUT72072A (en) | 1996-03-28 |
| KR950704301A (ko) | 1995-11-17 |
| CZ282581B6 (cs) | 1997-08-13 |
| FI952049L (fi) | 1995-04-28 |
| FI952049A7 (fi) | 1995-04-28 |
| SK54795A3 (en) | 1995-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |