CA2148687A1 - Oligonucleotides antisens pour l'inhibition de l'expression de genes mutants et de genes de type sauvage dans le cas du collagene - Google Patents
Oligonucleotides antisens pour l'inhibition de l'expression de genes mutants et de genes de type sauvage dans le cas du collageneInfo
- Publication number
- CA2148687A1 CA2148687A1 CA002148687A CA2148687A CA2148687A1 CA 2148687 A1 CA2148687 A1 CA 2148687A1 CA 002148687 A CA002148687 A CA 002148687A CA 2148687 A CA2148687 A CA 2148687A CA 2148687 A1 CA2148687 A1 CA 2148687A1
- Authority
- CA
- Canada
- Prior art keywords
- collagen
- seq
- oligonucleotide
- sequence
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Biochemistry (AREA)
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- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
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| US97333292A | 1992-11-09 | 1992-11-09 | |
| US07/973,332 | 1992-11-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2148687A1 true CA2148687A1 (fr) | 1994-05-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002148687A Abandoned CA2148687A1 (fr) | 1992-11-09 | 1993-11-09 | Oligonucleotides antisens pour l'inhibition de l'expression de genes mutants et de genes de type sauvage dans le cas du collagene |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0674705A4 (fr) |
| JP (1) | JPH08503366A (fr) |
| CA (1) | CA2148687A1 (fr) |
| WO (1) | WO1994011494A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780611A (en) * | 1995-09-15 | 1998-07-14 | Ramareddy Venkata Guntaka | Oligomers which inhibit expression of collagen genes |
| US6156513A (en) * | 1995-09-15 | 2000-12-05 | Ramareddy V. Guntaka | Oligmers which inhibit expression of collagen genes |
| US5808037A (en) * | 1995-09-15 | 1998-09-15 | Ramareddy Venkata Guntaka | Oligomers which inhibit expression of collagen genes |
| GB9519299D0 (en) | 1995-09-21 | 1995-11-22 | Farrar Gwyneth J | Genetic strategy |
| GB9604449D0 (en) * | 1996-03-01 | 1996-05-01 | Farrar Gwyneth J | Genetic strategy ii |
| US8551970B2 (en) | 1996-04-02 | 2013-10-08 | Optigen Patents Limited | Genetic suppression and replacement |
| GB9606961D0 (en) | 1996-04-02 | 1996-06-05 | Farrar Gwyneth J | Genetic strategy III |
| US5814500A (en) * | 1996-10-31 | 1998-09-29 | The Johns Hopkins University School Of Medicine | Delivery construct for antisense nucleic acids and methods of use |
| CA2283636A1 (fr) * | 1997-03-20 | 1998-09-24 | Variagenics, Inc. | Genes cibles pour medicaments specifiques d'alleles |
| US6200754B1 (en) | 1998-03-19 | 2001-03-13 | Variagenics, Inc. | Inhibitors of alternative alleles of genes encoding products that mediate cell response to environmental changes |
| US6939712B1 (en) * | 1998-12-29 | 2005-09-06 | Impedagen, Llc | Muting gene activity using a transgenic nucleic acid |
| GB9929487D0 (en) | 1999-12-15 | 2000-02-09 | Zeneca Ltd | Antisense oligonucleotides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2006008C (fr) * | 1988-12-20 | 2000-02-15 | Donald J. Kessler | Methode pour obtenir des oligonucleotides synthetiques qui se lient specifiquement a des sites cibles sur des molecules d'adn double brin, en formant un triplex colineaire; methode d'utilisation de ces oligonucleotides synthetiques |
| EP0666923A1 (fr) * | 1991-09-05 | 1995-08-16 | The University Of Connecticut | Apport cible de polynucleotides ou d'oligonucleotides a des cellules |
-
1993
- 1993-11-09 EP EP94901327A patent/EP0674705A4/fr not_active Withdrawn
- 1993-11-09 JP JP6512264A patent/JPH08503366A/ja active Pending
- 1993-11-09 CA CA002148687A patent/CA2148687A1/fr not_active Abandoned
- 1993-11-09 WO PCT/US1993/010756 patent/WO1994011494A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0674705A1 (fr) | 1995-10-04 |
| JPH08503366A (ja) | 1996-04-16 |
| WO1994011494A1 (fr) | 1994-05-26 |
| EP0674705A4 (fr) | 1997-11-26 |
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