CA2157902A1 - Ciblage de tumeurs a l'aide de conjugues d'oligonucleotide l-enantiomeres d'immunoreactifs et de radionucleides chelates - Google Patents

Ciblage de tumeurs a l'aide de conjugues d'oligonucleotide l-enantiomeres d'immunoreactifs et de radionucleides chelates

Info

Publication number: CA2157902A1
Authority: CA; Canada
Prior art keywords: enantiomeric; residue; precursor; reagent; group
Prior art date: 1993-03-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002157902A

Other languages

English (en)

Inventor

Christopher Douglas Valiant Black

Robert Allen Snow

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wellcome Foundation Ltd

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-10

Filing date

1994-03-10

Publication date

1994-09-15

1994-03-10 Application filed by Individual filed Critical Individual

1994-09-15 Publication of CA2157902A1 publication Critical patent/CA2157902A1/fr

Status Abandoned legal-status Critical Current

Links

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238000000034 method Methods 0.000 claims abstract description 65
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239000012634 fragment Substances 0.000 claims abstract description 6
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
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239000002243 precursor Substances 0.000 claims description 57
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ACTRVOBWPAIOHC-XIXRPRMCSA-N succimer Chemical compound OC(=O)[C@@H](S)[C@@H](S)C(O)=O ACTRVOBWPAIOHC-XIXRPRMCSA-N 0.000 description 1
229960005346 succimer Drugs 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
150000003464 sulfur compounds Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
239000012085 test solution Substances 0.000 description 1
UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
YNHJECZULSZAQK-UHFFFAOYSA-N tetraphenylporphyrin Chemical compound C1=CC(C(=C2C=CC(N2)=C(C=2C=CC=CC=2)C=2C=CC(N=2)=C(C=2C=CC=CC=2)C2=CC=C3N2)C=2C=CC=CC=2)=NC1=C3C1=CC=CC=C1 YNHJECZULSZAQK-UHFFFAOYSA-N 0.000 description 1
229910052716 thallium Inorganic materials 0.000 description 1
TXBBUSUXYMIVOS-UHFFFAOYSA-N thenoyltrifluoroacetone Chemical compound FC(F)(F)C(=O)CC(=O)C1=CC=CS1 TXBBUSUXYMIVOS-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
230000004797 therapeutic response Effects 0.000 description 1
150000007970 thio esters Chemical class 0.000 description 1
125000004001 thioalkyl group Chemical group 0.000 description 1
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
125000000101 thioether group Chemical group 0.000 description 1
150000003568 thioethers Chemical class 0.000 description 1
ATGUDZODTABURZ-UHFFFAOYSA-N thiolan-2-ylideneazanium;chloride Chemical compound Cl.N=C1CCCS1 ATGUDZODTABURZ-UHFFFAOYSA-N 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
229910052718 tin Inorganic materials 0.000 description 1
238000003325 tomography Methods 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
229910052721 tungsten Inorganic materials 0.000 description 1
DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
229940045145 uridine Drugs 0.000 description 1
239000013598 vector Substances 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
230000029812 viral genome replication Effects 0.000 description 1
238000009736 wetting Methods 0.000 description 1
238000004846 x-ray emission Methods 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Public Health (AREA)
Physics & Mathematics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Optics & Photonics (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

CA002157902A 1993-03-10 1994-03-10 Ciblage de tumeurs a l'aide de conjugues d'oligonucleotide l-enantiomeres d'immunoreactifs et de radionucleides chelates Abandoned CA2157902A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US3308393A	1993-03-10	1993-03-10
US033083		1993-03-10
PCT/US1994/002610 WO1994020523A1 (fr)	1993-03-10	1994-03-10	Ciblage de tumeur au moyen de conjugues oligonucleotidiques l-enantiomeres d'immunoreactifs et de radionucleides chelates

Publications (1)

Publication Number	Publication Date
CA2157902A1 true CA2157902A1 (fr)	1994-09-15

Family

ID=21868470

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002157902A Abandoned CA2157902A1 (fr)	1993-03-10	1994-03-10	Ciblage de tumeurs a l'aide de conjugues d'oligonucleotide l-enantiomeres d'immunoreactifs et de radionucleides chelates

Country Status (5)

Country	Link
EP (1)	EP0691981A1 (fr)
JP (1)	JPH08512019A (fr)
AU (1)	AU6402594A (fr)
CA (1)	CA2157902A1 (fr)
WO (1)	WO1994020523A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE203168T1 (de) *	1992-05-07	2001-08-15	Nycomed Imaging As	Komplexbildnermittel und zielimmunoreagenzien
US6444652B1 (en) *	1998-08-10	2002-09-03	Novirio Pharmaceuticals Limited	β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
US6395716B1 (en) *	1998-08-10	2002-05-28	Novirio Pharmaceuticals Limited	β-L-2′-deoxy-nucleosides for the treatment of hepatitis B
US6787526B1 (en)	2000-05-26	2004-09-07	Idenix Pharmaceuticals, Inc.	Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en)	2000-06-15	2005-04-05	Idenix Pharmaceuticals, Inc.	3′-prodrugs of 2′-deoxy-β-L-nucleosides
ATE452655T1 (de) *	2001-06-10	2010-01-15	Noxxon Pharma Ag	Verwendung von l-polynukleotiden zur diagnostischen bilderzeugung
EP1288309A1 (fr) *	2001-08-30	2003-03-05	Noxxon Pharma AG	Procédé pour marquer les L-acides nucléiques
US6942972B2 (en) *	2001-10-24	2005-09-13	Beckman Coulter, Inc.	Efficient synthesis of protein-oligonucleotide conjugates
EP1306382A1 (fr) *	2001-10-26	2003-05-02	Noxxon Pharma AG	L-acides nucléiques modifiés
EP1438321B1 (fr) *	2001-10-26	2010-05-26	Noxxon Pharma AG	Acide l-nucleique modifie
TWI244393B (en)	2002-08-06	2005-12-01	Idenix Pharmaceuticals Inc	Crystalline and amorphous forms of beta-L-2'-deoxythymidine
SI1572095T1 (sl)	2002-09-13	2015-12-31	Novartis Ag	Beta-l-2'-deoksinukleozidi za uporabo pri zdravljenju odpornih sevov hbv

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4863713A (en) *	1986-06-23	1989-09-05	The Board Of Trustees Of Leland Stanford Jr. Univ.	Method and system for administering therapeutic and diagnostic agents
US5158880A (en) *	1988-09-23	1992-10-27	E. I. Du Pont De Nemours And Company	Process for preparing solid perfluorocarbon polymer supports having attached perfluorocarbon-substituted ligand or binder
US5367080A (en) *	1990-11-08	1994-11-22	Sterling Winthrop Inc.	Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods

1994
- 1994-03-10 EP EP94911542A patent/EP0691981A1/fr not_active Withdrawn
- 1994-03-10 WO PCT/US1994/002610 patent/WO1994020523A1/fr not_active Ceased
- 1994-03-10 AU AU64025/94A patent/AU6402594A/en not_active Abandoned
- 1994-03-10 CA CA002157902A patent/CA2157902A1/fr not_active Abandoned
- 1994-03-10 JP JP6520313A patent/JPH08512019A/ja active Pending

Also Published As

Publication number	Publication date
EP0691981A1 (fr)	1996-01-17
JPH08512019A (ja)	1996-12-17
WO1994020523A1 (fr)	1994-09-15
AU6402594A (en)	1994-09-26

Legal Events

Date	Code	Title	Description
1998-03-10	FZDE	Discontinued

Publication	Publication Date	Title
US5733523A (en)	1998-03-31	Targeted delivery of a therapeutic entity using complementary oligonucleotides
EP0251494B1 (fr)	1992-09-30	Composé thérapeutique ou radiodiagnostique
CA2150477A1 (fr)	1994-06-09	Ciblage sequentiel des sites tumoraux a l'aide de conjugues oligonucleotidiques d'anticorps et de conjugues oligonucleotidiques complementaires de radionucleides chelates
AU6402594A (en)	1994-09-26	Tumor targeting with l-enantiomeric oligonucleotide conjugates of immunoreagents and of chelated radionuclides
JP3143506B2 (ja)	2001-03-07	治療用物質の標的送達用医薬組成物
JP2009197024A (ja)	2009-09-03	金属複合体及びオリゴヌクレオチドから作られた接合体、該接合体を含む薬剤、放射線診断におけるそれらの使用並びにそれらの製造のための方法
US5746997A (en)	1998-05-05	Radiohalogenation of oligonucleotides via trialkylstannylaryl conjugates
US20020077306A1 (en)	2002-06-20	Conjugates made of metal complexes and oligonucleotides, agents containing the conjugates, their use in radiodiagnosis as well as process for their production
EP0675737A1 (fr)	1995-10-11	Reactifs a reactivite immunologique utilisant la dihydrofolate reductase
EP0613379B1 (fr)	1998-08-12	Composes therapeutiques
CA2164518A1 (fr)	1994-12-22	Agents immunoreactifs utilisant la monoamine-oxydase
CA2154896A1 (fr)	1994-08-04	Agents immunoreactifs utilisant des heterodimeres
US7713528B1 (en)	2010-05-11	Method for in vivo delivery of active compounds using reagent conjugate
WO1997033626A1 (fr)	1997-09-18	Nouveaux chelateurs et compositions preparees a l'aide de ceux-ci
Gambhir	2001	New Gene Based Probes for Imaging Breast Cancer with PET
AU2036099A (en)	1999-06-17	Conjugates made of metal complexes and oligonucleotides