CA2164155C - Vaccin a base de polysaccharide permettant d'ameliorer l'immunite contre la brucellose - Google Patents
Vaccin a base de polysaccharide permettant d'ameliorer l'immunite contre la brucellose Download PDFInfo
- Publication number
- CA2164155C CA2164155C CA 2164155 CA2164155A CA2164155C CA 2164155 C CA2164155 C CA 2164155C CA 2164155 CA2164155 CA 2164155 CA 2164155 A CA2164155 A CA 2164155A CA 2164155 C CA2164155 C CA 2164155C
- Authority
- CA
- Canada
- Prior art keywords
- brucella
- vaccine
- ops
- polysaccharide
- abortus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010006500 Brucellosis Diseases 0.000 title claims abstract description 31
- 230000036039 immunity Effects 0.000 title description 7
- 229940031937 polysaccharide vaccine Drugs 0.000 title description 5
- 229960005486 vaccine Drugs 0.000 claims abstract description 69
- 241000589562 Brucella Species 0.000 claims abstract description 30
- 230000004224 protection Effects 0.000 claims abstract description 30
- 208000015181 infectious disease Diseases 0.000 claims abstract description 25
- 241000894006 Bacteria Species 0.000 claims abstract description 21
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 20
- 239000005017 polysaccharide Substances 0.000 claims abstract description 20
- 241000589567 Brucella abortus Species 0.000 claims description 38
- 102000036639 antigens Human genes 0.000 claims description 23
- 108091007433 antigens Proteins 0.000 claims description 23
- 239000000427 antigen Substances 0.000 claims description 22
- 229940056450 brucella abortus Drugs 0.000 claims description 16
- 241001148111 Brucella suis Species 0.000 claims description 14
- 241000607142 Salmonella Species 0.000 claims description 10
- 241000607447 Yersinia enterocolitica Species 0.000 claims description 7
- 229940098232 yersinia enterocolitica Drugs 0.000 claims description 7
- 241000588732 Atlantibacter hermannii Species 0.000 claims description 5
- 241001148106 Brucella melitensis Species 0.000 claims description 5
- 241000588724 Escherichia coli Species 0.000 claims description 5
- 241000589602 Francisella tularensis Species 0.000 claims description 5
- 241000122973 Stenotrophomonas maltophilia Species 0.000 claims description 5
- 229940038698 brucella melitensis Drugs 0.000 claims description 5
- 229940118764 francisella tularensis Drugs 0.000 claims description 5
- 241000607626 Vibrio cholerae Species 0.000 claims description 4
- 230000002480 immunoprotective effect Effects 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 231100000252 nontoxic Toxicity 0.000 claims description 4
- 230000003000 nontoxic effect Effects 0.000 claims description 4
- 230000004936 stimulating effect Effects 0.000 claims description 4
- 229940118696 vibrio cholerae Drugs 0.000 claims description 4
- 230000024932 T cell mediated immunity Effects 0.000 claims description 2
- 241000606748 Actinobacillus pleuropneumoniae Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
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- 239000002158 endotoxin Substances 0.000 description 31
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- 238000002347 injection Methods 0.000 description 17
- 239000007924 injection Substances 0.000 description 17
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- 241000282898 Sus scrofa Species 0.000 description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 210000000952 spleen Anatomy 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
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- UEHGPSGGFKLPTD-KVTDHHQDSA-N perosamine Chemical compound C[C@@H](O)[C@@H](N)[C@H](O)[C@H](O)C=O UEHGPSGGFKLPTD-KVTDHHQDSA-N 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- CVBNMWXECPZOLM-UHFFFAOYSA-N Rhamnetin Natural products COc1cc(O)c2C(=O)C(=C(Oc2c1)c3ccc(O)c(O)c3O)O CVBNMWXECPZOLM-UHFFFAOYSA-N 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
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- 238000004383 yellowing Methods 0.000 description 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 description 1
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- 108010067770 Endopeptidase K Proteins 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 241001646719 Escherichia coli O157:H7 Species 0.000 description 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
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- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
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- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
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- 239000012507 Sephadex™ Substances 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 229920002359 Tetronic® Polymers 0.000 description 1
- 241000775914 Valdivia <angiosperm> Species 0.000 description 1
- 241000607734 Yersinia <bacteria> Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- SHZGCJCMOBCMKK-PQMKYFCFSA-N alpha-D-rhamnose Chemical compound C[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O SHZGCJCMOBCMKK-PQMKYFCFSA-N 0.000 description 1
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- 239000002955 immunomodulating agent Substances 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
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- PIQIFFQSDJDXOS-DBRKOABJSA-N n-[(2r,3r,4s,5s)-2,4,5-trihydroxy-6-oxohexan-3-yl]formamide Chemical compound O=CN[C@H]([C@H](O)C)[C@H](O)[C@H](O)C=O PIQIFFQSDJDXOS-DBRKOABJSA-N 0.000 description 1
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- 238000007747 plating Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/098—Brucella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2164155 CA2164155C (fr) | 1995-11-30 | 1995-11-30 | Vaccin a base de polysaccharide permettant d'ameliorer l'immunite contre la brucellose |
| US08/672,063 US5951987A (en) | 1995-08-22 | 1996-09-16 | Polysaccharide vaccine to enhance immunity against brucellosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2164155 CA2164155C (fr) | 1995-11-30 | 1995-11-30 | Vaccin a base de polysaccharide permettant d'ameliorer l'immunite contre la brucellose |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2164155A1 CA2164155A1 (fr) | 1997-05-31 |
| CA2164155C true CA2164155C (fr) | 2005-06-21 |
Family
ID=4157067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2164155 Expired - Lifetime CA2164155C (fr) | 1995-08-22 | 1995-11-30 | Vaccin a base de polysaccharide permettant d'ameliorer l'immunite contre la brucellose |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2164155C (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6444210B1 (en) | 1996-07-03 | 2002-09-03 | Her Majesty the Queen in right of Canada, as represented by the Minister of National Defence of Her Majesty′s Canadian Goverment | Bacterial and synthetic polysaccharide immunomodulators that enhance general immunity |
-
1995
- 1995-11-30 CA CA 2164155 patent/CA2164155C/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2164155A1 (fr) | 1997-05-31 |
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