CA2165200A1 - Antagonistes et agonistes de neuropeptide y - Google Patents
Antagonistes et agonistes de neuropeptide yInfo
- Publication number
- CA2165200A1 CA2165200A1 CA002165200A CA2165200A CA2165200A1 CA 2165200 A1 CA2165200 A1 CA 2165200A1 CA 002165200 A CA002165200 A CA 002165200A CA 2165200 A CA2165200 A CA 2165200A CA 2165200 A1 CA2165200 A1 CA 2165200A1
- Authority
- CA
- Canada
- Prior art keywords
- ala
- arg
- group
- lys
- homo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- SNVLJLYUUXKWOJ-UHFFFAOYSA-N methylidenecarbene Chemical compound C=[C] SNVLJLYUUXKWOJ-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- CMWYAOXYQATXSI-UHFFFAOYSA-N n,n-dimethylformamide;piperidine Chemical compound CN(C)C=O.C1CCNCC1 CMWYAOXYQATXSI-UHFFFAOYSA-N 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 239000002660 neuropeptide Y receptor antagonist Substances 0.000 description 1
- BPGXUIVWLQTVLZ-OFGSCBOVSA-N neuropeptide y(npy) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 BPGXUIVWLQTVLZ-OFGSCBOVSA-N 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 230000001956 orexigenic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000012495 positive regulation of renal sodium excretion Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 206010038464 renal hypertension Diseases 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 231100000872 sexual dysfunction Toxicity 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005556 structure-activity relationship Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000006442 vascular tone Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57545—Neuropeptide Y
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention décrit des analogues se comportant comme des antagonistes et des agonistes du NPY, ainsi que des méthodes d'utilisation de ces composés, permettant de contrôler une activité biologique telle que l'appétit et la fonction cardio-vasculaire.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7931993A | 1993-06-18 | 1993-06-18 | |
| US08/079,319 | 1993-06-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2165200A1 true CA2165200A1 (fr) | 1995-01-05 |
Family
ID=22149788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002165200A Abandoned CA2165200A1 (fr) | 1993-06-18 | 1994-06-16 | Antagonistes et agonistes de neuropeptide y |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0707490A1 (fr) |
| JP (1) | JPH11501281A (fr) |
| AU (1) | AU7174494A (fr) |
| CA (1) | CA2165200A1 (fr) |
| WO (1) | WO1995000161A1 (fr) |
| ZA (1) | ZA944338B (fr) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516653A (en) * | 1993-12-28 | 1996-05-14 | Synaptic Pharmaceutical Corporation | DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof |
| US5545549A (en) | 1994-02-03 | 1996-08-13 | Synaptic Pharmaceutical Corporation | DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof |
| US5989920A (en) * | 1994-12-02 | 1999-11-23 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5 |
| US5602024A (en) | 1994-12-02 | 1997-02-11 | Synaptic Pharmaceutical Corporation | DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof |
| EP0759441A3 (fr) * | 1995-06-30 | 1999-06-30 | Eli Lilly And Company | Procédés de traitement des pathologies associées aux peptides neuropeptide Y |
| ZA965346B (en) * | 1995-06-30 | 1997-12-24 | Lilly Co Eli | Methods of treating neuropeptide Y-associated conditions. |
| US5943242A (en) | 1995-11-17 | 1999-08-24 | Pact Gmbh | Dynamically reconfigurable data processing system |
| US7266725B2 (en) | 2001-09-03 | 2007-09-04 | Pact Xpp Technologies Ag | Method for debugging reconfigurable architectures |
| FR2754709B1 (fr) * | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
| DE19651075A1 (de) | 1996-12-09 | 1998-06-10 | Pact Inf Tech Gmbh | Einheit zur Verarbeitung von numerischen und logischen Operationen, zum Einsatz in Prozessoren (CPU's), Mehrrechnersystemen, Datenflußprozessoren (DFP's), digitalen Signal Prozessoren (DSP's) oder dergleichen |
| CA2274594C (fr) * | 1996-12-16 | 2006-10-10 | Banyu Pharmaceutical Co., Ltd. | Derives d'aminopyrazole |
| DE19654593A1 (de) | 1996-12-20 | 1998-07-02 | Pact Inf Tech Gmbh | Umkonfigurierungs-Verfahren für programmierbare Bausteine zur Laufzeit |
| US6338106B1 (en) | 1996-12-20 | 2002-01-08 | Pact Gmbh | I/O and memory bus system for DFPS and units with two or multi-dimensional programmable cell architectures |
| DE19654846A1 (de) | 1996-12-27 | 1998-07-09 | Pact Inf Tech Gmbh | Verfahren zum selbständigen dynamischen Umladen von Datenflußprozessoren (DFPs) sowie Bausteinen mit zwei- oder mehrdimensionalen programmierbaren Zellstrukturen (FPGAs, DPGAs, o. dgl.) |
| DE19704728A1 (de) | 1997-02-08 | 1998-08-13 | Pact Inf Tech Gmbh | Verfahren zur Selbstsynchronisation von konfigurierbaren Elementen eines programmierbaren Bausteines |
| US6542998B1 (en) | 1997-02-08 | 2003-04-01 | Pact Gmbh | Method of self-synchronization of configurable elements of a programmable module |
| DE19704742A1 (de) | 1997-02-11 | 1998-09-24 | Pact Inf Tech Gmbh | Internes Bussystem für DFPs, sowie Bausteinen mit zwei- oder mehrdimensionalen programmierbaren Zellstrukturen, zur Bewältigung großer Datenmengen mit hohem Vernetzungsaufwand |
| GB2338235B (en) | 1997-04-15 | 2001-11-14 | Csir | Appetite suppressing plant extracts |
| US6713265B1 (en) | 1997-06-04 | 2004-03-30 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) |
| US7003660B2 (en) | 2000-06-13 | 2006-02-21 | Pact Xpp Technologies Ag | Pipeline configuration unit protocols and communication |
| GB2355657B (en) | 1999-10-27 | 2004-07-28 | Phytopharm Plc | Inhibitors Of Gastric Acid Secretion |
| GB2363985B (en) | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
| AU2002220600A1 (en) | 2000-10-06 | 2002-04-15 | Pact Informationstechnologie Gmbh | Cell system with segmented intermediate cell structure |
| US6990555B2 (en) | 2001-01-09 | 2006-01-24 | Pact Xpp Technologies Ag | Method of hierarchical caching of configuration data having dataflow processors and modules having two- or multidimensional programmable cell structure (FPGAs, DPGAs, etc.) |
| US7581076B2 (en) | 2001-03-05 | 2009-08-25 | Pact Xpp Technologies Ag | Methods and devices for treating and/or processing data |
| US7210129B2 (en) | 2001-08-16 | 2007-04-24 | Pact Xpp Technologies Ag | Method for translating programs for reconfigurable architectures |
| US7444531B2 (en) | 2001-03-05 | 2008-10-28 | Pact Xpp Technologies Ag | Methods and devices for treating and processing data |
| US7434191B2 (en) | 2001-09-03 | 2008-10-07 | Pact Xpp Technologies Ag | Router |
| GB0217015D0 (en) * | 2002-07-23 | 2002-08-28 | Bioacta Ltd | Peptide 4 |
| WO2004038599A1 (fr) | 2002-09-06 | 2004-05-06 | Pact Xpp Technologies Ag | Structure de sequenceur reconfigurable |
| WO2004098591A2 (fr) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibiteurs de glutaminyl-cyclase |
| AU2004290499C1 (en) | 2003-11-03 | 2011-02-24 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| CA2554809C (fr) | 2004-02-05 | 2014-04-29 | Probiodrug Ag | Nouveaux inhibiteurs de la glutaminyl-cyclase comportant de la n thiouree alkyle et de l'imidazolyl substitue par thioamide |
| WO2007097742A1 (fr) * | 2006-02-21 | 2007-08-30 | University Of Cincinnati | Méthodes en rapport avec des récepteurs induits par des corticoïdes |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (fr) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Dérivés de thio-urée utilisés comme inhibiteurs de la glutaminyl cyclase |
| CN102325544A (zh) * | 2009-02-20 | 2012-01-18 | 益普生制药股份有限公司 | 具有34位脯氨酸替换的神经肽y的类似物 |
| JP5480301B2 (ja) * | 2009-02-20 | 2014-04-23 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | 少なくとも１個の合成アミノ酸置換を有する神経ペプチドｙの類似体 |
| JP5584236B2 (ja) * | 2009-02-20 | 2014-09-03 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | 神経ペプチドｙ受容体結合化合物を有する細胞毒性コンジュゲート |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (fr) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Nouveaux inhibiteurs |
| EP2686313B1 (fr) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Dérivés de benzimidazole en tant qu'inhibiteurs de la glutaminyl cyclase |
| EP3337497B1 (fr) * | 2015-08-21 | 2023-07-12 | SRX Cardio, LLC | Composition et procédés d'utilisation de nouveaux petits composés organiques de phénylalanine pour moduler directement l'activité de la protéine pcsk9 |
| EP3337564A4 (fr) | 2015-08-21 | 2019-01-23 | Portola Pharmaceuticals, Inc. | Composition et procédés d'utilisation de petites molécules de type tétrahydroisoquinoline pour se lier à pcsk9 et moduler l'activité protéique de pcsk9 |
| HK1257102A1 (zh) | 2015-08-21 | 2019-10-11 | Portola Pharmaceuticals, Inc. | 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用 |
| WO2017147328A1 (fr) | 2016-02-23 | 2017-08-31 | Portola Pharmaceuticals, Inc. | Composés se liant à la proprotéine convertase subtilisine/kexine de type 9 (pcsk9) |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| US12115154B2 (en) | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839343A (en) * | 1987-03-13 | 1989-06-13 | Debiopharm, S.A. | Preparation containing hexatriacontapeptides and methods of use |
| US5026685A (en) * | 1988-07-15 | 1991-06-25 | The Salk Institute For Biological Studies | NPY peptide analogs |
| ZA896376B (en) * | 1988-08-26 | 1990-05-30 | Merrell Dow Pharma | Neuropeptide y agonists |
-
1994
- 1994-06-16 CA CA002165200A patent/CA2165200A1/fr not_active Abandoned
- 1994-06-16 EP EP94920757A patent/EP0707490A1/fr not_active Withdrawn
- 1994-06-16 AU AU71744/94A patent/AU7174494A/en not_active Abandoned
- 1994-06-16 WO PCT/US1994/006837 patent/WO1995000161A1/fr not_active Ceased
- 1994-06-16 JP JP7502963A patent/JPH11501281A/ja active Pending
- 1994-06-17 ZA ZA944338A patent/ZA944338B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0707490A1 (fr) | 1996-04-24 |
| AU7174494A (en) | 1995-01-17 |
| JPH11501281A (ja) | 1999-02-02 |
| WO1995000161A1 (fr) | 1995-01-05 |
| ZA944338B (en) | 1995-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |