CA2170766A1 - Inhibiteurs di- et tripeptidiques substitues de l'enzyme proteine:la farnesyle transferase - Google Patents

Inhibiteurs di- et tripeptidiques substitues de l'enzyme proteine:la farnesyle transferase

Info

Publication number
CA2170766A1
CA2170766A1 CA002170766A CA2170766A CA2170766A1 CA 2170766 A1 CA2170766 A1 CA 2170766A1 CA 002170766 A CA002170766 A CA 002170766A CA 2170766 A CA2170766 A CA 2170766A CA 2170766 A1 CA2170766 A1 CA 2170766A1
Authority
CA
Canada
Prior art keywords
obn
tyr
cbz
ser
co2me
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002170766A
Other languages
English (en)
Inventor
Gary Louis Bolton
Mark Wallace Creswell
John Cooke Hodges
Michael William Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2170766A1 publication Critical patent/CA2170766A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne de nouveaux inhibiteurs de l'enzyme protéine:farnésyle transférase, de même que des procédés de préparation de ceux-ci ainsi que des compositions pharmaceutiques contenant lesdits inhibiteurs, lesquels sont utiles dans la maîtrise des maladies à prolifération tissulaire, notamment le cancer et la resténose.
CA002170766A 1993-11-05 1994-10-12 Inhibiteurs di- et tripeptidiques substitues de l'enzyme proteine:la farnesyle transferase Abandoned CA2170766A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14873593A 1993-11-05 1993-11-05
US148,735 1993-11-05
US30330194A 1994-09-13 1994-09-13
US303,301 1994-09-13

Publications (1)

Publication Number Publication Date
CA2170766A1 true CA2170766A1 (fr) 1995-05-11

Family

ID=26846110

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002170766A Abandoned CA2170766A1 (fr) 1993-11-05 1994-10-12 Inhibiteurs di- et tripeptidiques substitues de l'enzyme proteine:la farnesyle transferase

Country Status (10)

Country Link
EP (1) EP0730605A1 (fr)
JP (1) JP3597863B2 (fr)
KR (1) KR100362338B1 (fr)
AU (1) AU681454B2 (fr)
CA (1) CA2170766A1 (fr)
FI (1) FI961819A0 (fr)
HU (1) HUT75308A (fr)
NO (1) NO961814L (fr)
NZ (1) NZ275691A (fr)
WO (1) WO1995012612A1 (fr)

Families Citing this family (87)

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US5652257A (en) * 1994-09-29 1997-07-29 Merck & Co., Inc. Heterocycle-containing inhibitors of farnesyl-protein transferase
EP0783517A2 (fr) * 1994-09-29 1997-07-16 Merck & Co. Inc. Inhibiteurs de la transferase de proteines farnesylees exempts de thiol
US5585359A (en) * 1994-09-29 1996-12-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5756528A (en) * 1995-06-06 1998-05-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5972984A (en) * 1995-06-06 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
FR2736641B1 (fr) * 1995-07-10 1997-08-22 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
US5968965A (en) * 1996-01-30 1999-10-19 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5981562A (en) * 1996-01-30 1999-11-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6011029A (en) * 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
WO1997044350A1 (fr) * 1996-05-22 1997-11-27 Warner-Lambert Company Inhibiteurs de farnesyltransferase de proteines
US6300501B1 (en) 1996-05-22 2001-10-09 Warner-Lambert Company Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
CO4920227A1 (es) 1996-12-17 2000-05-29 Warner Lambert Co Histidina-n-bencil glicinamida sustituida con cicloalquilos .
FR2757855B1 (fr) * 1996-12-30 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
US6013662A (en) * 1996-12-30 2000-01-11 Rhone-Poulenc Rorer S.A. Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
US6124465A (en) * 1997-11-25 2000-09-26 Rhone-Poulenc S.A. Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
US6423689B1 (en) 1997-12-22 2002-07-23 Warner-Lambert Company Peptidyl calcium channel blockers
WO1999043658A1 (fr) 1998-02-27 1999-09-02 Warner-Lambert Company Agents d'aniline heterocyclique substituee bloquant les canaux de calcium
US6166052A (en) 1998-03-11 2000-12-26 Warner-Lambert Company Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers
MXPA00009619A (es) 1998-04-02 2006-03-09 Targacept Inc Composiciones farmaceuticas y metodos de uso.
JP2002513031A (ja) 1998-04-27 2002-05-08 ワーナー−ランバート・カンパニー ファルネシルトランスフェラーゼ阻害剤としての機能化されたアルキルおよびアルケニル側鎖を有するグリシンアミド誘導体
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US20010031771A1 (en) 1999-05-24 2001-10-18 Gary Maurice Dull Pharmaceutical compositions and methods for use
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ES2382814T3 (es) 2005-05-17 2012-06-13 Merck Sharp & Dohme Ltd. Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
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US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
JP4611444B2 (ja) 2007-01-10 2011-01-12 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール
CA2679659C (fr) 2007-03-01 2016-01-19 Novartis Ag Inhibiteurs de pim kinase et procedes de leur utilisation
AU2008254425A1 (en) 2007-05-21 2008-11-27 Novartis Ag CSF-1R inhibitors, compositions, and methods of use
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TW200946105A (en) 2008-02-07 2009-11-16 Kyorin Seiyaku Kk Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient
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US8765747B2 (en) 2009-06-12 2014-07-01 Dana-Farber Cancer Institute, Inc. Fused 2-aminothiazole compounds
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072033A1 (fr) * 1991-06-28 1992-12-29 Jackson B. Gibbs Inhibiteur de la farnesyl-proteine-transferase ne se rapportant pas a un substrat

Also Published As

Publication number Publication date
NO961814L (no) 1996-05-06
FI961819A7 (fi) 1996-04-29
FI961819L (fi) 1996-04-29
JPH09504547A (ja) 1997-05-06
FI961819A0 (fi) 1996-04-29
JP3597863B2 (ja) 2004-12-08
KR100362338B1 (ko) 2003-04-08
HUT75308A (en) 1997-05-28
NO961814D0 (no) 1996-05-03
HU9601193D0 (en) 1996-07-29
AU681454B2 (en) 1997-08-28
NZ275691A (en) 1998-03-25
WO1995012612A1 (fr) 1995-05-11
AU7976094A (en) 1995-05-23
EP0730605A1 (fr) 1996-09-11

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued