JP3597863B2 - タンパク質：ファルネシルトランスフェラーゼの置換されたジ‐およびトリペプチド阻害剤 - Google Patents

タンパク質：ファルネシルトランスフェラーゼの置換されたジ‐およびトリペプチド阻害剤 Download PDF

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Publication number
JP3597863B2
JP3597863B2 JP51322495A JP51322495A JP3597863B2 JP 3597863 B2 JP3597863 B2 JP 3597863B2 JP 51322495 A JP51322495 A JP 51322495A JP 51322495 A JP51322495 A JP 51322495A JP 3597863 B2 JP3597863 B2 JP 3597863B2
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obn
tyr
compound
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aryl
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Japanese (ja)
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JPH09504547A (ja
Inventor
ボールトン，ゲアリー・ルイス
クレスウエル，マーク・ウオリス
ホツジズ，ジヨン・クツク
ウイルソン，マイクル・ウイリアム
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ワーナー−ランバート・コンパニー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
JP51322495A 1993-11-05 1994-10-12 タンパク質：ファルネシルトランスフェラーゼの置換されたジ‐およびトリペプチド阻害剤 Expired - Fee Related JP3597863B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14873593A 1993-11-05 1993-11-05
US08/148,735 1993-11-05
US30330194A 1994-09-13 1994-09-13
US08/303,301 1994-09-13
PCT/US1994/011553 WO1995012612A1 (fr) 1993-11-05 1994-10-12 Inhibiteurs di- et tripeptidiques substitues de l'enzyme proteine:la farnesyle transferase

Publications (2)

Publication Number Publication Date
JPH09504547A JPH09504547A (ja) 1997-05-06
JP3597863B2 true JP3597863B2 (ja) 2004-12-08

Family

ID=26846110

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51322495A Expired - Fee Related JP3597863B2 (ja) 1993-11-05 1994-10-12 タンパク質：ファルネシルトランスフェラーゼの置換されたジ‐およびトリペプチド阻害剤

Country Status (10)

Country Link
EP (1) EP0730605A1 (fr)
JP (1) JP3597863B2 (fr)
KR (1) KR100362338B1 (fr)
AU (1) AU681454B2 (fr)
CA (1) CA2170766A1 (fr)
FI (1) FI961819A0 (fr)
HU (1) HUT75308A (fr)
NO (1) NO961814L (fr)
NZ (1) NZ275691A (fr)
WO (1) WO1995012612A1 (fr)

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US5585359A (en) * 1994-09-29 1996-12-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5756528A (en) * 1995-06-06 1998-05-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5972984A (en) * 1995-06-06 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
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US6011029A (en) * 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
WO1997044350A1 (fr) * 1996-05-22 1997-11-27 Warner-Lambert Company Inhibiteurs de farnesyltransferase de proteines
US6300501B1 (en) 1996-05-22 2001-10-09 Warner-Lambert Company Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
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FR2757855B1 (fr) * 1996-12-30 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
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WO1999043658A1 (fr) 1998-02-27 1999-09-02 Warner-Lambert Company Agents d'aniline heterocyclique substituee bloquant les canaux de calcium
US6166052A (en) 1998-03-11 2000-12-26 Warner-Lambert Company Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers
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Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
NO961814L (no) 1996-05-06
FI961819A7 (fi) 1996-04-29
FI961819L (fi) 1996-04-29
JPH09504547A (ja) 1997-05-06
FI961819A0 (fi) 1996-04-29
CA2170766A1 (fr) 1995-05-11
KR100362338B1 (ko) 2003-04-08
HUT75308A (en) 1997-05-28
NO961814D0 (no) 1996-05-03
HU9601193D0 (en) 1996-07-29
AU681454B2 (en) 1997-08-28
NZ275691A (en) 1998-03-25
WO1995012612A1 (fr) 1995-05-11
AU7976094A (en) 1995-05-23
EP0730605A1 (fr) 1996-09-11

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