CA2175457A1 - Traitement de l'arthrite rhumatoide - Google Patents
Traitement de l'arthrite rhumatoideInfo
- Publication number
- CA2175457A1 CA2175457A1 CA002175457A CA2175457A CA2175457A1 CA 2175457 A1 CA2175457 A1 CA 2175457A1 CA 002175457 A CA002175457 A CA 002175457A CA 2175457 A CA2175457 A CA 2175457A CA 2175457 A1 CA2175457 A1 CA 2175457A1
- Authority
- CA
- Canada
- Prior art keywords
- crf
- days
- administration
- patient
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000006243 chemical reaction Methods 0.000 description 1
- 229940001468 citrate Drugs 0.000 description 1
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 description 1
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- 239000000284 extract Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
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- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- -1 hydrobro-20 mide Chemical compound 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
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- 238000011694 lewis rat Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
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- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
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- 150000002772 monosaccharides Chemical class 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
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- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003076 paracrine Effects 0.000 description 1
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- 210000000578 peripheral nerve Anatomy 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
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- 230000028327 secretion Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
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- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2228—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'administration du facteur de libération de la corticotropine (FLC) à des patients souffrant d'une arthrite inflammatoire telle que l'arthrite rhumatoïde a pour effet de réduire les réponses inflammatoires aiguës épisodiques symptomatiques de la chronicité de la maladie. Les doses de FLC prévues par l'invention ont des effets anti-inflammatoires, même dans les cas d'affections bien installées.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14652093A | 1993-11-02 | 1993-11-02 | |
| US08/146,520 | 1993-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2175457A1 true CA2175457A1 (fr) | 1995-05-11 |
Family
ID=22517765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002175457A Abandoned CA2175457A1 (fr) | 1993-11-02 | 1994-11-02 | Traitement de l'arthrite rhumatoide |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0726780A1 (fr) |
| JP (1) | JPH09504792A (fr) |
| AU (1) | AU8131694A (fr) |
| CA (1) | CA2175457A1 (fr) |
| CZ (1) | CZ122696A3 (fr) |
| HU (1) | HUT74275A (fr) |
| LT (1) | LT96079A (fr) |
| NO (1) | NO961747L (fr) |
| PL (1) | PL314191A1 (fr) |
| WO (1) | WO1995012416A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060288A (en) * | 1994-08-03 | 2000-05-09 | Mosaic Technologies | Method for performing amplification of nucleic acid on supports |
| US5780431A (en) * | 1996-09-20 | 1998-07-14 | Neurobiological Technologies, Inc. | Pharmaceutical formulations of corticotropin releasing factor having improved stability in liquid form |
| JP2002503954A (ja) | 1997-04-01 | 2002-02-05 | グラクソ、グループ、リミテッド | 核酸増幅法 |
| AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
| EP1565436B1 (fr) * | 2002-11-27 | 2012-04-25 | Incyte Corporation | Derives de la 3-aminopyrrolidine modulateurs des recepteurs de la chemoquine |
| WO2008093098A2 (fr) | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Procedes pour indexer des echantillons et sequencer de multiples matrices nucleotidiques |
| WO2010038042A1 (fr) | 2008-10-02 | 2010-04-08 | Illumina Cambridge Ltd. | Enrichissement d'échantillons d'acide nucléique pour des applications de séquençage |
| US8182994B2 (en) | 2009-09-15 | 2012-05-22 | Illumina Cambridge Limited | Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing |
| DE102011100783A1 (de) | 2011-05-06 | 2012-11-08 | Rolls-Royce Deutschland Ltd & Co Kg | Gasturbinenauswuchtvorrichtung |
| CN115137809A (zh) * | 2021-03-31 | 2022-10-04 | 张菁 | 含有促肾上腺皮质激素及其衍生物的药物及其用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5006330A (en) * | 1988-11-30 | 1991-04-09 | The United States Of America As Represented By The Of The Department Of Health And Human Services | Evaluative means for detecting inflammatory reactivity |
-
1994
- 1994-11-02 PL PL94314191A patent/PL314191A1/xx unknown
- 1994-11-02 JP JP7513400A patent/JPH09504792A/ja active Pending
- 1994-11-02 HU HU9601149A patent/HUT74275A/hu unknown
- 1994-11-02 CA CA002175457A patent/CA2175457A1/fr not_active Abandoned
- 1994-11-02 EP EP95900514A patent/EP0726780A1/fr not_active Withdrawn
- 1994-11-02 CZ CZ961226A patent/CZ122696A3/cs unknown
- 1994-11-02 WO PCT/US1994/012621 patent/WO1995012416A1/fr not_active Ceased
- 1994-11-02 AU AU81316/94A patent/AU8131694A/en not_active Abandoned
-
1996
- 1996-04-30 NO NO961747A patent/NO961747L/no unknown
- 1996-05-31 LT LT96-079A patent/LT96079A/lt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LT96079A (en) | 1996-10-25 |
| WO1995012416A1 (fr) | 1995-05-11 |
| PL314191A1 (en) | 1996-09-02 |
| EP0726780A1 (fr) | 1996-08-21 |
| AU8131694A (en) | 1995-05-23 |
| HUT74275A (en) | 1996-11-28 |
| NO961747L (no) | 1996-07-02 |
| JPH09504792A (ja) | 1997-05-13 |
| HU9601149D0 (en) | 1996-06-28 |
| NO961747D0 (no) | 1996-04-30 |
| CZ122696A3 (en) | 1996-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |