CA2181553C - Derive de pyrrolopyridazine - Google Patents

Derive de pyrrolopyridazine Download PDF

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Publication number
CA2181553C
CA2181553C CA002181553A CA2181553A CA2181553C CA 2181553 C CA2181553 C CA 2181553C CA 002181553 A CA002181553 A CA 002181553A CA 2181553 A CA2181553 A CA 2181553A CA 2181553 C CA2181553 C CA 2181553C
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CA
Canada
Prior art keywords
group
acceptable salts
pharmacologically acceptable
pyridazine
ch2ch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002181553A
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English (en)
Other versions
CA2181553A1 (fr
Inventor
Tomio Kimura
Yoshimi (Deceased) Fujihara
Nobuhiko Shibakawa
Hiroshi Fujiwara
Etsuro Itoh
Keiji Matsunobu
Keiichi Tabata
Hiroshi Yasuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Priority claimed from PCT/JP1995/000038 external-priority patent/WO1995019980A1/fr
Publication of CA2181553A1 publication Critical patent/CA2181553A1/fr
Application granted granted Critical
Publication of CA2181553C publication Critical patent/CA2181553C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

Dérivé de pyrrolopyridazine représenté par la formule générale (I) et sel de ce composé acceptable en pharmacologie. Dans la formule, R?1¿ représente alcényle C¿2?-C¿6?, alcényle C¿2?-C¿6? halogéné, alcényle C¿2?-C¿6? substitué par aryle C¿6?-C¿10?, alkynyle C¿2?-C¿6?, cycloalkyle C¿3?-C¿7?, alkyle C¿1?-C¿6? substitué par cycloalkyle C¿3?-C¿7?, alkyle C¿1?-C¿6? substitué par cycloalcényle C¿5?-C¿7?, ou alkyle C¿1?-C¿6? halogéné; R?2¿ et R?3¿ représentent chacun indépendamment hydrogène, alkyle C¿1?-C¿6? ou aryle C¿6?-C¿10?; R?4¿ représente hydrogène ou alkyle C¿1?-C¿6?; R?5¿ représente aryle C¿6?-C¿10? ou un hétéroaryle comportant de cinq à 10 éléments, dans lequel le(s) hétéroatome(s) est(sont) sélectionné(s) parmi des atomes d'azote, d'oxygène ou de soufre; A représente alkylène C¿1?-C¿3?; X représente imino, oxygène soufre ou méthylène; m représente 0 ou 1; et n représente 0 ou 1. Ce dérivé présente une excellente action de suppression des sécrétions gastriques et de protection des muqueuses gastriques, ainsi qu'une excellente activité antibactérienne contre l'Helicobacter pylori, ce qui permet de l'utiliser pour prévenir ou soigner les affections ulcératives et des troubles similaires.
CA002181553A 1994-01-19 1995-01-18 Derive de pyrrolopyridazine Expired - Fee Related CA2181553C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP06-3988 1994-01-19
JP398894 1994-01-19
PCT/JP1995/000038 WO1995019980A1 (fr) 1994-01-19 1995-01-18 Derive de pyrrolopyridazine

Publications (2)

Publication Number Publication Date
CA2181553A1 CA2181553A1 (fr) 1995-07-27
CA2181553C true CA2181553C (fr) 2005-11-22

Family

ID=35474760

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002181553A Expired - Fee Related CA2181553C (fr) 1994-01-19 1995-01-18 Derive de pyrrolopyridazine

Country Status (1)

Country Link
CA (1) CA2181553C (fr)

Also Published As

Publication number Publication date
CA2181553A1 (fr) 1995-07-27

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