CA2183992A1 - Procede et reactif inhibiteur de l'expression de genes concernant une affection - Google Patents

Procede et reactif inhibiteur de l'expression de genes concernant une affection

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Publication number
CA2183992A1
CA2183992A1 CA 2183992 CA2183992A CA2183992A1 CA 2183992 A1 CA2183992 A1 CA 2183992A1 CA 2183992 CA2183992 CA 2183992 CA 2183992 A CA2183992 A CA 2183992A CA 2183992 A1 CA2183992 A1 CA 2183992A1
Authority
CA
Canada
Prior art keywords
rna
nucleic acid
ribozyme
molecule
acid molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2183992
Other languages
English (en)
Inventor
Dan T. Stinchcomb
Bharat Chowrira
Anthony Direnzo
Kenneth G. Draper
Lech W. Dudycz
Susan Grimm
Alexander Karpeisky
Kevin Kisich
Jasenka Matulic-Adamic
James A. Mcswiggen
Anil Modak
Pamela Pavco
Leonid Beigelman
Sean M. Sullivan
David Sweedler
James D. Thompson
Danuta Tracz
Nassim Usman
Francine E. Wincott
Tod Woolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sirna Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/218,934 external-priority patent/US5639647A/en
Priority claimed from US08/291,932 external-priority patent/US5658780A/en
Priority claimed from US08/292,620 external-priority patent/US5837542A/en
Priority claimed from US08/311,486 external-priority patent/US5811300A/en
Priority claimed from US08/319,492 external-priority patent/US5616488A/en
Priority claimed from US08/321,993 external-priority patent/US5631359A/en
Priority claimed from US08/334,847 external-priority patent/US5693532A/en
Priority claimed from US08/337,608 external-priority patent/US5902880A/en
Priority claimed from US08/357,577 external-priority patent/US5783425A/en
Priority claimed from US08/363,233 external-priority patent/US5714383A/en
Priority to CA002468048A priority Critical patent/CA2468048A1/fr
Application filed by Individual filed Critical Individual
Publication of CA2183992A1 publication Critical patent/CA2183992A1/fr
Abandoned legal-status Critical Current

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  • Enzymes And Modification Thereof (AREA)

Abstract

La présente invention concerne des molécules d'ARN enzymatiques clivant les ARNm ICAM-1, IL-5, rel A, TNF-.alpha., RSV, l'ARN génomique RSV ou l'ARNm associé du CML, ainsi que l'utilisation de ces molécules pour le traitement des états pathologiques imputables à ces niveaux de l'ARNm. L'invention concerne également: des ribonucléosides ou des nucléotides modifiés en 2', 3' ou 5' ainsi que les procédés de synthèse, de purification et de déprotection correspondants; des vecteurs contenant des acides nucléiques enzymatiques multiples, éventuellement associés à des ARNt sous des formes chimériques; un procédé d'introduction des acides nucléiques enzymatiques dans des cellules par constitution d'un complexe avec un second acide nucléique, ledit complexe étant capable de prendre une structure en paires de base bouclée en R; un procédé de modification in vivo d'un acide nucléique mutant par hybridation avec un oligonucléotide capable d'activer la désaminase de l'ARNds à activité enzymatique ou chimiquement mutagène. L'invention concerne enfin des ribozymes en épingle à cheveux transclivants ou transligants auxquels manque une moitié d'ARN substratique, ainsi que des ribozymes en tête de marteau à interconnexions en boucle entre les paires de base de la souche II.
CA 2183992 1994-02-23 1995-02-23 Procede et reactif inhibiteur de l'expression de genes concernant une affection Abandoned CA2183992A1 (fr)

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CA002468048A CA2468048A1 (fr) 1994-02-23 1995-02-23 Procede de purification de rna synthetise par voie chimique

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US22279594A 1994-04-04 1994-04-04
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US24573694A 1994-05-18 1994-05-18
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US30303994A 1994-09-08 1994-09-08
US08/303,039 1994-09-08
US31174994A 1994-09-23 1994-09-23
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US38073495A 1995-01-30 1995-01-30
US08/271,280 1995-01-30
US08/228,041 1995-01-30
US08/314,397 1995-01-30
US08/291,932 1995-01-30
US08/300,000 1995-01-30
US08/311,749 1995-01-30
US08/218,934 1995-01-30
US08/292,620 1995-01-30
US08/345,516 1995-01-30
US08/222,795 1995-01-30
US08/245,736 1995-01-30
US08/293,520 1995-01-30
US08/311,486 1995-01-30
US08/319,492 1995-01-30
US08/227,958 1995-01-30
US08/334,847 1995-01-30
US08/321,993 1995-01-30
US08/380,734 1995-01-30
US08/337,608 1995-01-30
US08/201,109 1995-01-30
US08/316,771 1995-01-30
US08/363,233 1995-01-30
US08/291,433 1995-01-30
US08/357,577 1995-01-30

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WO1995023225A3 (fr) 1996-02-01

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