CA2184365C - Compositions de solution d'acetaminophene concentre - Google Patents

Compositions de solution d'acetaminophene concentre Download PDF

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Publication number
CA2184365C
CA2184365C CA002184365A CA2184365A CA2184365C CA 2184365 C CA2184365 C CA 2184365C CA 002184365 A CA002184365 A CA 002184365A CA 2184365 A CA2184365 A CA 2184365A CA 2184365 C CA2184365 C CA 2184365C
Authority
CA
Canada
Prior art keywords
concentrated liquid
pharmaceutical composition
composition according
liquid pharmaceutical
peg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002184365A
Other languages
English (en)
Other versions
CA2184365A1 (fr
Inventor
Dadi Jamshed Dhabhar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of CA2184365A1 publication Critical patent/CA2184365A1/fr
Application granted granted Critical
Publication of CA2184365C publication Critical patent/CA2184365C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des compositions pharmaceutiques liquides concentrées améliorées contenant de l'acétaminophène, lequel est obtenu par addition d'un catalyseur de transposition de Beckmann dans une oxime de 4-hydroxyacétophénone.
CA002184365A 1994-03-02 1995-02-27 Compositions de solution d'acetaminophene concentre Expired - Fee Related CA2184365C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US204,932 1994-03-02
US08/204,932 US5510389A (en) 1994-03-02 1994-03-02 Concentrated acetaminophen solution compositions
PCT/US1995/002488 WO1995023595A1 (fr) 1994-03-02 1995-02-27 Compositions de solution d'acetaminophene concentre

Publications (2)

Publication Number Publication Date
CA2184365A1 CA2184365A1 (fr) 1995-09-08
CA2184365C true CA2184365C (fr) 2000-12-05

Family

ID=22760078

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002184365A Expired - Fee Related CA2184365C (fr) 1994-03-02 1995-02-27 Compositions de solution d'acetaminophene concentre

Country Status (4)

Country Link
US (1) US5510389A (fr)
AU (1) AU1935795A (fr)
CA (1) CA2184365C (fr)
WO (1) WO1995023595A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751875B1 (fr) * 1996-08-05 1998-12-24 Scr Newpharm Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
US6160020A (en) * 1996-12-20 2000-12-12 Mcneill-Ppc, Inc. Alkali metal and alkaline-earth metal salts of acetaminophen
US20020082307A1 (en) * 1999-01-11 2002-06-27 Dobrozsi Douglas Joseph Compositions having improved stability
US20020086878A1 (en) * 1999-01-11 2002-07-04 Douglas Joseph Dobrozsi Compositions having improved stability
US6846495B2 (en) 1999-01-11 2005-01-25 The Procter & Gamble Company Compositions having improved delivery of actives
AU773385B2 (en) * 1999-05-14 2004-05-27 Esperion Luv Development, Inc. Method of treating angina and/or anginal equivalents, and pharmaceutical compositions and kit related thereto
IT1313579B1 (it) * 1999-07-30 2002-09-09 Acraf Composizione farmaceutica liquida a base di paracetamolo.
KR100355532B1 (ko) * 1999-10-27 2002-10-09 서울대학교 공과대학 교육연구재단 수소가 치환된 다공질 결정성 규산 알루미늄 촉매를 이용하여 아세트아미노펜을 합성하는 방법
WO2002036077A2 (fr) * 2000-11-06 2002-05-10 Andrx Pharmaceuticals, Inc. Preparation decongestionnante et antihistaminique a prise quotidienne unique
US7138133B2 (en) 2001-10-10 2006-11-21 The Procter & Gamble Company Orally administered liquid compositions
US7101572B2 (en) * 2001-12-07 2006-09-05 Unilab Pharmatech, Ltd. Taste masked aqueous liquid pharmaceutical composition
EA006939B1 (ru) * 2001-12-18 2006-06-30 Юни-Фарма Клеон Цетис Фармасьютикал Лэборетериз С. А. Парентеральная композиция парацетамола
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
BG65674B1 (bg) * 2003-07-10 2009-06-30 Нихфи Ад Течна форма на комбинирано лекарствено средство за лечение на простудни и грипни заболявания
US20060088590A1 (en) * 2004-10-22 2006-04-27 Banner Pharmacaps, Inc. Non-blooming gelatin and non-gelatin formulations
CN101262860A (zh) * 2005-06-03 2008-09-10 伊兰制药国际有限公司 纳米微粒对乙酰氨基酚制剂
DE102007000521A1 (de) * 2007-10-18 2009-04-23 Renate Conrad Hustenpräparat
ES2465228T5 (es) † 2008-02-08 2022-03-18 Procter & Gamble Proceso para fabricar una bolsa soluble en agua
US8518438B2 (en) * 2011-01-14 2013-08-27 Enspire Group, Llc Highly concentrated liquid acetaminophen solutions
US8969416B2 (en) * 2012-03-29 2015-03-03 Enspire Group LLC Polyvinylpyrrolidone-containing acetaminophen liquid formulations
NZ709958A (en) 2013-02-28 2018-03-23 Pfizer Enhanced stability of novel liquid compositions
CN107847496A (zh) * 2015-02-20 2018-03-27 英仕柏集团有限责任公司 含有非索非那丁的软明胶胶囊
WO2017058836A1 (fr) * 2015-09-28 2017-04-06 Puracap Pharmaceutical Llc Capsules de gélatine molle contenant un mélange d'analgésiques et de décongestionnants, d'expectorants, d'antitussifs et/ou d'antihistaminiques
US20180055938A1 (en) * 2016-09-01 2018-03-01 The Procter & Gamble Company Medication With Improved Taste And Sensory Experience
WO2018183082A1 (fr) * 2017-03-27 2018-10-04 Paracap Pharmaceutical Llc Formulations contenant des expectorants ou des décongestionnants
CA3100314A1 (fr) 2018-05-16 2019-11-21 Bayer Healthcare Llc Formulation de suspension a concentration elevee pour medicaments a capsule molle contre le rhume et la grippe
US20210330594A1 (en) * 2018-09-11 2021-10-28 Puracap Pharmaceutical Llc Fast-Acting Soft Gelatin Capsules Containing A Mixture Of Pain Reliever/Fever Reducer, Diuretic And Antihistamine
WO2021105524A1 (fr) * 2019-11-25 2021-06-03 Mmc International Health Holding, S.L. Composition pharmaceutique de sel d'ibuprofène avec de la lysine sous forme de solution orale

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520134A (en) * 1982-08-27 1985-05-28 Rosen Gerald M N-alkyl-4'-hydroxyacetanilides, pharmaceutical compositions comprising them and their use
US4565890A (en) * 1983-10-27 1986-01-21 Mallinckrodt, Inc. Process for the preparation of N-acetyl-P-aminophenol
US5155269A (en) * 1984-01-30 1992-10-13 Mallinckrodt Purification of p-aminophenol compositions and direct conversion to N-acetyl-p-aminophenol
US4524217A (en) * 1984-06-08 1985-06-18 Celanese Corporation Process for producing N-acyl-hydroxy aromatic amines
US5071643A (en) * 1986-10-17 1991-12-10 R. P. Scherer Corporation Solvent system enhancing the solubility of pharmaceuticals for encapsulation
US4760093A (en) * 1986-10-21 1988-07-26 American Home Products Corporation (Del.) Spray dried acetaminophen
US5155273A (en) * 1988-07-12 1992-10-13 Hoechst Celanese Corporation Production of acetaminophen
JP2958021B2 (ja) * 1989-05-26 1999-10-06 キヤノン株式会社 画像形成装置
JP2801391B2 (ja) * 1989-12-27 1998-09-21 三井化学株式会社 ｐ―アセチルアミノフェノールの製造法
US5141961A (en) * 1991-06-27 1992-08-25 Richrdson-Vicks Inc. Process for solubilizing difficulty soluble pharmaceutical actives
US5344979A (en) * 1993-04-29 1994-09-06 Hoechst Celanese Corporation Process for preparing color-stabilized acetaminophen
US5505961A (en) * 1993-08-05 1996-04-09 R. P. Scherer Corporation Gelatin capsules containing a highly concentrated acetaminophen solution

Also Published As

Publication number Publication date
US5510389A (en) 1996-04-23
CA2184365A1 (fr) 1995-09-08
AU1935795A (en) 1995-09-18
WO1995023595A1 (fr) 1995-09-08

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