CA2184631A1 - Produit et procede de regulation des voies de transduction de signaux - Google Patents
Produit et procede de regulation des voies de transduction de signauxInfo
- Publication number
- CA2184631A1 CA2184631A1 CA002184631A CA2184631A CA2184631A1 CA 2184631 A1 CA2184631 A1 CA 2184631A1 CA 002184631 A CA002184631 A CA 002184631A CA 2184631 A CA2184631 A CA 2184631A CA 2184631 A1 CA2184631 A1 CA 2184631A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- motif
- amino acid
- kinase
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
- C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Saccharide Compounds (AREA)
Abstract
L'invention concerne des produits et des procédés de régulation de voies de transduction de signaux dans des cellules. L'invention se rapporte d'une part, à un peptide présentant un motif aminoacide YXXLXXXXXXXYXX? et utile dans la régulation de l'activité des tyrosine-kinases, des lipide-kinases et des molécules d'adaptation. Elle porte, d'autre part, sur un produit et un procédé d'inhibition de voies de transduction de signaux dans des cellules impliquant un peptide capable de se lier au domaine SH3 d'une tyrosine-kinase, pour bloquer ainsi la liaison et l'activation d'un effecteur par la tyrosine-kinase. Le composé et la composition peptidique peuvent être utilisés dans le traitement de troubles médicaux tels que les réactions allergiques, les maladies auto-immunes, les réactions inflammatoires, le cancer, les déficiences immunitaires, les maladies immunoprolifératives et celles dues à des virus tels que le virus Epstein-Barr et le virus de la leucémie bovine.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21511694A | 1994-03-17 | 1994-03-17 | |
| US215,116 | 1994-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2184631A1 true CA2184631A1 (fr) | 1995-09-21 |
Family
ID=22801724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002184631A Abandoned CA2184631A1 (fr) | 1994-03-17 | 1995-03-17 | Produit et procede de regulation des voies de transduction de signaux |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0804218A1 (fr) |
| JP (1) | JPH09512704A (fr) |
| CA (1) | CA2184631A1 (fr) |
| WO (1) | WO1995024915A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976819A (en) * | 1995-11-21 | 1999-11-02 | National Jewish Medical And Research Center | Product and process to regulate actin polymerization in T lymphocytes |
| BR9712556A (pt) | 1996-10-23 | 1999-10-19 | Univ Pennsylvania | Plasmìdeo, composição farmacêutica, e, processo de imunizar um indivìduo contra um antìgeno |
| US6420338B1 (en) * | 1997-06-13 | 2002-07-16 | New York University Medical Center | Inhibition of the Src kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma |
| US6503509B1 (en) * | 1999-02-25 | 2003-01-07 | National Jewish Medical & Research Center | Method for receptor desensitization |
| JPWO2003006060A1 (ja) * | 2001-07-09 | 2004-10-28 | 協和醗酵工業株式会社 | Ｓｈ３ドメイン結合阻害剤 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT100037B (pt) * | 1991-01-18 | 1999-06-30 | Univ New York | Processo de expressao-clonacao para detectar proteinas alvo para tirosina-quinases de receptores sonda polipeptidica e proteinas grb humanas |
| US5352660A (en) * | 1991-10-31 | 1994-10-04 | Mount Sinai Hospital Corporation | Method for assaying for a substance that affects a SH2-phosphorylated ligand regulatory system |
| US5770396A (en) * | 1992-04-16 | 1998-06-23 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation characterization, and use of the human beta subunit of the high affinity receptor for immunoglobulin E |
| IL101769A (en) * | 1992-05-03 | 2007-02-11 | Yeda Res & Dev | Modulation of TNF receptor action |
| WO1994017095A1 (fr) * | 1993-01-29 | 1994-08-04 | Ariad Pharmaceuticals, Inc. | Analogues de motifs d'activation de tyrosine de recepteurs et leurs utilisations therapeutiques |
| WO1994018832A1 (fr) * | 1993-02-26 | 1994-09-01 | Dana-Farber Cancer Institute, Inc. | Modulation a mediation cd4 de kinases lipidiques |
| FI950729A7 (fi) * | 1993-06-30 | 1995-04-19 | Pharmacia & Upjohn Spa | Mitogeneesia ja motogeneesia inhiboivat peptidit |
| EP0772773B1 (fr) * | 1994-07-22 | 2006-04-05 | The University Of North Carolina | PEPTIDES SE FIXANT AUX SH3 DE Src ET LEURS METHODES D'ISOLEMENT ET D'UTILISATION |
| JPH11501622A (ja) * | 1995-02-28 | 1999-02-09 | ナショナル ジューイッシュ センター フォー イミュノロジー アンド レスピラトリー メディスン | 造血機能を調整するｉｔｉｍモチーフを含むペプチジル化合物とその利用 |
| US7815749B2 (en) * | 2006-06-29 | 2010-10-19 | Hitachi Metals, Ltd. | Method for manufacturing semi-hard magnetic material and semi-hard magnetic material |
-
1995
- 1995-03-17 EP EP95914756A patent/EP0804218A1/fr not_active Withdrawn
- 1995-03-17 WO PCT/US1995/003438 patent/WO1995024915A1/fr not_active Ceased
- 1995-03-17 CA CA002184631A patent/CA2184631A1/fr not_active Abandoned
- 1995-03-17 JP JP7524210A patent/JPH09512704A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU699662B2 (en) | 1998-12-10 |
| JPH09512704A (ja) | 1997-12-22 |
| EP0804218A4 (fr) | 1997-11-12 |
| EP0804218A1 (fr) | 1997-11-05 |
| WO1995024915A1 (fr) | 1995-09-21 |
| AU2187495A (en) | 1995-10-03 |
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| EEER | Examination request | ||
| FZDE | Discontinued |