CA2186513C - Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis - Google Patents

Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis

Info

Publication number
CA2186513C
CA2186513C CA002186513A CA2186513A CA2186513C CA 2186513 C CA2186513 C CA 2186513C CA 002186513 A CA002186513 A CA 002186513A CA 2186513 A CA2186513 A CA 2186513A CA 2186513 C CA2186513 C CA 2186513C
Authority
CA
Canada
Prior art keywords
formula
methyl
compound
alkyl
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002186513A
Other languages
English (en)
French (fr)
Other versions
CA2186513A1 (en
Inventor
James F. Eggler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Publication of CA2186513A1 publication Critical patent/CA2186513A1/en
Application granted granted Critical
Publication of CA2186513C publication Critical patent/CA2186513C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002186513A 1994-03-28 1995-01-18 Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis Expired - Fee Related CA2186513C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21878894A 1994-03-28 1994-03-28
US08/218,788 1994-03-28

Publications (2)

Publication Number Publication Date
CA2186513A1 CA2186513A1 (en) 1995-10-05
CA2186513C true CA2186513C (en) 1999-03-16

Family

ID=22816518

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002186513A Expired - Fee Related CA2186513C (en) 1994-03-28 1995-01-18 Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis

Country Status (11)

Country Link
US (1) US5665749A (de)
EP (1) EP0752990B1 (de)
JP (1) JP2841120B2 (de)
AT (1) ATE169298T1 (de)
CA (1) CA2186513C (de)
DE (1) DE69503890T2 (de)
DK (1) DK0752990T3 (de)
ES (1) ES2119377T3 (de)
FI (1) FI963882L (de)
GR (1) GR3027598T3 (de)
WO (1) WO1995026346A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227197B1 (en) * 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
GB0316546D0 (en) 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
DE102005005397B4 (de) 2005-02-05 2008-08-21 Lts Lohmann Therapie-Systeme Ag Isolierung von N-Butylbenzolsulfonamid, Synthese von Benzolsulfonamid-Derivaten sowie Verwendung von N-Butylbenzolsulfonamid und Benzolsulfonamid-Derivaten zur Behandlung der benignen Prostatahyperplasie und/oder des Prostatakarzinoms
CN104042617A (zh) 2009-04-29 2014-09-17 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法
WO2016149126A1 (en) 2015-03-13 2016-09-22 The Board Of Trustees Of The Leland Stanford Junior University Ltb4 inhibition to prevent and treat human lymphedema
US11724991B1 (en) * 2023-01-06 2023-08-15 King Faisal University Selective 5-LO inhibitors for the treatment of bronchial asthma

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8926981D0 (en) * 1988-12-23 1990-01-17 Ici Plc Heterocyclic derivatives
US5134148A (en) * 1989-02-28 1992-07-28 Imperial Chemical Industries Plc Heterocycles for use as inhibitors of leukotrienes
US5196419A (en) * 1989-02-28 1993-03-23 Imperial Chemical Industries Plc Heterocyclic cyclic ethers
IE70521B1 (en) * 1989-02-28 1996-12-11 Zeneca Pharma Sa Heterocycles with inhibitory activity of 5-lipoxygenase
IE911919A1 (en) * 1990-06-21 1992-01-01 Zeneca Ltd Bicyclic heterocyclic compounds
JPH04128276A (ja) * 1990-09-19 1992-04-28 Pfizer Pharmaceut Co Ltd アミノベンゾサルタム誘導体およびその用途

Also Published As

Publication number Publication date
US5665749A (en) 1997-09-09
DK0752990T3 (da) 1999-02-08
JP2841120B2 (ja) 1998-12-24
FI963882A7 (fi) 1996-09-27
GR3027598T3 (en) 1998-11-30
EP0752990A1 (de) 1997-01-15
WO1995026346A1 (en) 1995-10-05
FI963882A0 (fi) 1996-09-27
FI963882L (fi) 1996-09-27
ATE169298T1 (de) 1998-08-15
MX9604429A (es) 1997-07-31
ES2119377T3 (es) 1998-10-01
DE69503890T2 (de) 1998-12-10
CA2186513A1 (en) 1995-10-05
DE69503890D1 (de) 1998-09-10
EP0752990B1 (de) 1998-08-05
JPH09507678A (ja) 1997-08-05

Similar Documents

Publication Publication Date Title
US4745117A (en) Imide derivatives and compositions for use as antipsychotic agents
US5298511A (en) Alkanoic acid derivatives
US4840951A (en) Novel naphthalene derivative
EP0219436A2 (de) Thiazolderivate und diese als wirksame Bestandteile enthaltender Leukotrien-Antagonist
EP0350403B1 (de) (Aza)Naphtalensultam-Derivate, Verfahren zu deren Herstellung und Arzneimittel, die sie enthalten
RU2169144C2 (ru) 5-феноксиалкил-2,4-тиазолидиндионы, способы их получения, содержащая их фармацевтическая композиция и промежуточные соединения
US5393775A (en) Benzopyran compounds
NZ229761A (en) Substituted thiazole derivatives for use as inhibitors of enzyme 5-lipoxygenase; pharmaceutical compositions and preparatory processes
CZ403692A3 (en) Aryl cycloalkyl derivatives, process of preparing such derivatives and their use
CA2186513C (en) Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis
EP0608568B1 (de) Aminocycloalkanobenzodioxole als beta-3 selektive adrenergische Wirkstoffe
EP0532239B1 (de) Benzolsulfonamidderivate als 5-Lipoxygenasehemmer
US4588715A (en) Heptenoic acid derivatives
US4083953A (en) Pharmaceutical composition containing 5:6-benzo-alpha-pyrone derivatives and method of use thereof
RO107656B1 (ro) Derivati de beta-carbonil-carboxiamide ale 1,3-tiazolidinelor si procedeu pentru prepararea acestora
EP0528935B1 (de) Alkoxy-substituierte dihydrobenzopyran-2-carbonsäure und deren derivate
AU617386B2 (en) Substituted quinolines
US5578619A (en) Alkoxy-substituted dihydrobenzopyran-2-sulfonimides
CA2184914C (en) Isoxazoline compounds as 5-lipoxygenase inhibitors
RU2041216C1 (ru) Производное бензотиазола или его фармакологически приемлемая соль
RO113856B1 (ro) Derivati ai sulfonamidei, procedee de preparare a acestora si preparate farmaceutice pentru terapia diabetului
CA1306464C (en) 2-(3, 5-dimethyl-4-hydroxyphenyl)indole derivatives
CA1193197A (en) Anti-inflammatory composition
MXPA96004429A (en) Heterociclic inhibitors of the biosynthesis de5-lipooxigen
JP2003277357A (ja) 電位依存性ナトリウムチャネル阻害活性を有する新規誘導体およびそれを有効成分として含有する医薬組成物

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed