CA2192073A1 - Nouveaux derives d'oligosides, leur procede de preparation et leurs applications - Google Patents

Nouveaux derives d'oligosides, leur procede de preparation et leurs applications

Info

Publication number
CA2192073A1
CA2192073A1 CA002192073A CA2192073A CA2192073A1 CA 2192073 A1 CA2192073 A1 CA 2192073A1 CA 002192073 A CA002192073 A CA 002192073A CA 2192073 A CA2192073 A CA 2192073A CA 2192073 A1 CA2192073 A1 CA 2192073A1
Authority
CA
Canada
Prior art keywords
molecule
preparation
method therefor
oligosaccharide derivatives
novel oligosaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002192073A
Other languages
English (en)
Other versions
CA2192073C (fr
Inventor
Michel Monsigny
Annie-Claude Roche
Nadia Sdiqui
Roger Mayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IDM Immuno Designed Molecules
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9407738A external-priority patent/FR2721612B1/fr
Application filed by Individual filed Critical Individual
Publication of CA2192073A1 publication Critical patent/CA2192073A1/fr
Application granted granted Critical
Publication of CA2192073C publication Critical patent/CA2192073C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Compounds including one or more oligosaccharides each of which is covalently bonded to one or more, particularly one, two or three, molecules, matrices or particles, by means of an intermediate molecule having a nitrogen atom on an .alpha. carbon of a C=O group and one or more, particularly one, two or three, functional groups, the covalent bond between said intermediate molecule and the oligosaccharide being via said nitrogen atom, and the covalent bond between said intermediate molecule and said molecule(s), matrix(-ces) or particle(s) being via said functional group(s) of said intermediate molecule and suitable functional groups on said molecule(s), matrix(-ces) or particle(s).
CA002192073A 1994-06-23 1995-06-15 Nouveaux derives d'oligosides, leur procede de preparation et leurs applications Expired - Fee Related CA2192073C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR94/07738 1994-06-23
FR9407738A FR2721612B1 (fr) 1994-06-23 1994-06-23 Nouveaux dérivés d'oligosides, leur procédé de préparation et leurs applications.
PCT/FR1995/000790 WO1996000229A1 (fr) 1994-06-23 1995-06-15 Nouveaux derives d'oligosides, leur procede de preparation et leurs applications

Publications (2)

Publication Number Publication Date
CA2192073A1 true CA2192073A1 (fr) 1996-01-04
CA2192073C CA2192073C (fr) 2006-08-01

Family

ID=36764261

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002192073A Expired - Fee Related CA2192073C (fr) 1994-06-23 1995-06-15 Nouveaux derives d'oligosides, leur procede de preparation et leurs applications

Country Status (1)

Country Link
CA (1) CA2192073C (fr)

Also Published As

Publication number Publication date
CA2192073C (fr) 2006-08-01

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed