CA2194397A1 - Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy}butyrique inhibiteur d'adhesion cellulaire - Google Patents
Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy}butyrique inhibiteur d'adhesion cellulaireInfo
- Publication number
- CA2194397A1 CA2194397A1 CA002194397A CA2194397A CA2194397A1 CA 2194397 A1 CA2194397 A1 CA 2194397A1 CA 002194397 A CA002194397 A CA 002194397A CA 2194397 A CA2194397 A CA 2194397A CA 2194397 A1 CA2194397 A1 CA 2194397A1
- Authority
- CA
- Canada
- Prior art keywords
- optically active
- pharmaceutically
- ester
- active compound
- amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La présente invention se rapporte à l'acide (-)-(3R)-3-méthyl-4-{4-[4-(4-pyridyl)pipérazin-1-yl]phénoxy}butyrique, nouveau composé doté d'une activité optique, ainsi qu'à ses sels, esters, amides, ou solvates pharmaceutiquement acceptables. Cette invention concerne également des procédés de préparation de ce composé, des compositions pharmaceutiques contenant ce composé et l'utilisation de ce composé comme inhibiteur de l'adhésion cellulaire, et notamment de l'agrégation plaquettaire.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/457538 | 1995-06-01 | ||
| US08/457,538 US5652242A (en) | 1993-03-29 | 1995-06-01 | Heterocyclic derivatives |
| GB9518188.9 | 1995-09-07 | ||
| GBGB9518188.9A GB9518188D0 (en) | 1995-09-07 | 1995-09-07 | Optically active derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2194397A1 true CA2194397A1 (fr) | 1996-12-05 |
Family
ID=26307696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002194397A Abandoned CA2194397A1 (fr) | 1995-06-01 | 1996-05-28 | Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy}butyrique inhibiteur d'adhesion cellulaire |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0796247A1 (fr) |
| JP (1) | JP2885941B2 (fr) |
| KR (1) | KR100245957B1 (fr) |
| AT (1) | AT406675B (fr) |
| AU (1) | AU710105B2 (fr) |
| BE (1) | BE1009520A5 (fr) |
| BR (1) | BR9606409A (fr) |
| CA (1) | CA2194397A1 (fr) |
| CH (1) | CH691808A5 (fr) |
| CZ (1) | CZ26997A3 (fr) |
| DE (1) | DE19680509T1 (fr) |
| DK (1) | DK10697A (fr) |
| ES (1) | ES2137886B1 (fr) |
| FI (1) | FI970393A0 (fr) |
| GB (1) | GB2304340B (fr) |
| GR (1) | GR1002702B (fr) |
| HU (1) | HUP9700274A3 (fr) |
| IE (1) | IE960405A1 (fr) |
| IL (1) | IL118477A0 (fr) |
| IT (1) | IT1290839B1 (fr) |
| LU (1) | LU90008B1 (fr) |
| MC (1) | MC2418A1 (fr) |
| MX (1) | MX9700379A (fr) |
| NL (1) | NL1003243C2 (fr) |
| NO (1) | NO307460B1 (fr) |
| NZ (1) | NZ308597A (fr) |
| PL (1) | PL318440A1 (fr) |
| SE (1) | SE510812C2 (fr) |
| SK (1) | SK13097A3 (fr) |
| TR (1) | TR199700020T1 (fr) |
| WO (1) | WO1996038416A1 (fr) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0100158A3 (fr) * | 1982-07-28 | 1985-03-27 | The Upjohn Company | Hétéroalkysylalkanoles 3-pyridinyliques, leurs acides alkanoiques et leurs esters |
| GB8609630D0 (en) * | 1986-04-19 | 1986-05-21 | Pfizer Ltd | Anti-arrhythmia agents |
| AU692438B2 (en) * | 1993-03-29 | 1998-06-11 | Astrazeneca Ab | Heterocyclic derivatives as platelet aggregation inhibitors |
| EP0690847A1 (fr) * | 1993-03-29 | 1996-01-10 | Zeneca Limited | Composes heterocycliques en tant qu'inhibiteurs de l'agregation plaquettaire |
-
1996
- 1996-05-28 AU AU58272/96A patent/AU710105B2/en not_active Ceased
- 1996-05-28 SK SK130-97A patent/SK13097A3/sk unknown
- 1996-05-28 EP EP96919906A patent/EP0796247A1/fr not_active Withdrawn
- 1996-05-28 PL PL96318440A patent/PL318440A1/xx unknown
- 1996-05-28 KR KR1019970700532A patent/KR100245957B1/ko not_active Expired - Fee Related
- 1996-05-28 DE DE19680509T patent/DE19680509T1/de not_active Withdrawn
- 1996-05-28 AT AT0900596A patent/AT406675B/de active
- 1996-05-28 JP JP8536281A patent/JP2885941B2/ja not_active Expired - Fee Related
- 1996-05-28 TR TR97/00020T patent/TR199700020T1/xx unknown
- 1996-05-28 ES ES009750006A patent/ES2137886B1/es not_active Expired - Fee Related
- 1996-05-28 NZ NZ308597A patent/NZ308597A/en unknown
- 1996-05-28 CH CH00224/97A patent/CH691808A5/de not_active IP Right Cessation
- 1996-05-28 FI FI970393A patent/FI970393A0/fi unknown
- 1996-05-28 WO PCT/GB1996/001260 patent/WO1996038416A1/fr not_active Ceased
- 1996-05-28 GR GR960100176A patent/GR1002702B/el not_active IP Right Cessation
- 1996-05-28 BR BR9606409A patent/BR9606409A/pt not_active Application Discontinuation
- 1996-05-28 CZ CZ97269A patent/CZ26997A3/cs unknown
- 1996-05-28 CA CA002194397A patent/CA2194397A1/fr not_active Abandoned
- 1996-05-28 GB GB9627127A patent/GB2304340B/en not_active Expired - Fee Related
- 1996-05-28 HU HU9700274A patent/HUP9700274A3/hu unknown
- 1996-05-28 MX MX9700379A patent/MX9700379A/es unknown
- 1996-05-29 MC MC2347A patent/MC2418A1/fr unknown
- 1996-05-30 IL IL11847796A patent/IL118477A0/xx unknown
- 1996-05-31 BE BE9600491A patent/BE1009520A5/fr not_active IP Right Cessation
- 1996-05-31 NL NL1003243A patent/NL1003243C2/xx not_active IP Right Cessation
- 1996-05-31 IE IE960405A patent/IE960405A1/en not_active IP Right Cessation
- 1996-05-31 IT IT96MI001113A patent/IT1290839B1/it active IP Right Grant
-
1997
- 1997-01-22 LU LU90008A patent/LU90008B1/fr active
- 1997-01-24 SE SE9700203A patent/SE510812C2/sv not_active IP Right Cessation
- 1997-01-30 DK DK010697A patent/DK10697A/da not_active Application Discontinuation
- 1997-01-31 NO NO970437A patent/NO307460B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |