CA2196281A1 - Produit d'assemblage immunogene a double porteur - Google Patents

Produit d'assemblage immunogene a double porteur

Info

Publication number
CA2196281A1
CA2196281A1 CA 2196281 CA2196281A CA2196281A1 CA 2196281 A1 CA2196281 A1 CA 2196281A1 CA 2196281 CA2196281 CA 2196281 CA 2196281 A CA2196281 A CA 2196281A CA 2196281 A1 CA2196281 A1 CA 2196281A1
Authority
CA
Canada
Prior art keywords
carrier
vaccine
molecular weight
primary
bsa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2196281
Other languages
English (en)
Inventor
James J. Mond
Andrew Lees
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henry M Jackson Foundation for Advancedment of Military Medicine Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2196281A1 publication Critical patent/CA2196281A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
    • C07K17/12—Cellulose or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Produit d'assemblage immunogène à double porteur constitué d'au moins un porteur primaire comprenant une molécule de masse moléculaire élevée supérieure à 70 kDa, et au moins un porteur secondaire comprenant un antigène T-dépendant conjugué à un porteur primaire. Le produit d'assemblage immunogène à double porteur peut également comprendre des fractions telles que des haptènes et des antigènes. Lesdits produits d'assemblage immunogènes sont adaptés à une utilisation dans le diagnostic, le traitement et la prévention de maladies.
CA 2196281 1995-06-06 1996-06-05 Produit d'assemblage immunogene a double porteur Abandoned CA2196281A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46806095A 1995-06-06 1995-06-06
US468,060 1995-06-06

Publications (1)

Publication Number Publication Date
CA2196281A1 true CA2196281A1 (fr) 1996-12-12

Family

ID=23858287

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2196281 Abandoned CA2196281A1 (fr) 1995-06-06 1996-06-05 Produit d'assemblage immunogene a double porteur

Country Status (5)

Country Link
EP (1) EP0776216A1 (fr)
JP (1) JPH10504842A (fr)
AU (1) AU6095196A (fr)
CA (1) CA2196281A1 (fr)
WO (1) WO1996039182A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202091382A1 (ru) 2017-12-06 2021-01-15 Мерк Шарп И Доум Корп. Композиции, содержащие конъюгаты полисахарид streptococcus pneumoniae с белком, и способы их применения
GEP20247633B (en) 2018-12-19 2024-06-25 Merck Sharp & Dohme Llc Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644059A (en) * 1982-07-06 1987-02-17 Connaught Laboratories, Inc. Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine
IL98715A0 (en) * 1990-08-13 1992-07-15 American Cyanamid Co Filamentous hemaglutinin of bodetella pertussis as a carrier molecule for conjugate vaccines
AU685047B2 (en) * 1992-02-11 1998-01-15 Henry M. Jackson Foundation For The Advancement Of Military Medicine Dual carrier immunogenic construct

Also Published As

Publication number Publication date
WO1996039182A1 (fr) 1996-12-12
JPH10504842A (ja) 1998-05-12
EP0776216A1 (fr) 1997-06-04
AU6095196A (en) 1996-12-24

Similar Documents

Publication Publication Date Title
US5955079A (en) Dual carrier immunogenic construct
Anderson Antibody responses to Haemophilus influenzae type b and diphtheria toxin induced by conjugates of oligosaccharides of the type b capsule with the nontoxic protein CRM197
AU678613B2 (en) Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs
EP0814833B1 (fr) Preparation de produits de recombinaison immunogenes au moyen d'hydrates de carbone solubles actives par l'intermediaire de reactifs organiques de cyanylation
JP5745221B2 (ja) タンパク質マトリックスワクチンおよびそのようなワクチンの製造方法および投与方法
EP0245078A2 (fr) Augmentation de l'immunogénicité d'antigènes
JPH04506662A (ja) 接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー
JP2013504588A (ja) 免疫原性の高いタンパク質マトリックスワクチン
AU763691B2 (en) Method for preparing solid phase conjugate vaccines
Peeters et al. Preparation of polysaccharide-conjugate vaccines
Paoletti et al. Preclinical evaluation of group B streptococcal polysaccharide conjugate vaccines prepared with a modified diphtheria toxin and a recombinant duck hepatitis B core antigen
CA2196281A1 (fr) Produit d'assemblage immunogene a double porteur
CN113663066B (zh) 一种肌醇阿拉伯甘露寡糖缀合物及在抗结核疫苗中的应用
Fattom Qualitative and quantitative immune response to bacterial capsular polysaccharides and their conjugates in mouse and man
CA1327523C (fr) Immunogenicite d'antigenes
HK1136220A (en) Protein matrix vaccines and methods of making and administering such vaccines

Legal Events

Date Code Title Description
FZDE Dead