CA2198557C - Method and apparatus for the production of nitric oxide gas mixture - Google Patents

Method and apparatus for the production of nitric oxide gas mixture Download PDF

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Publication number
CA2198557C
CA2198557C CA002198557A CA2198557A CA2198557C CA 2198557 C CA2198557 C CA 2198557C CA 002198557 A CA002198557 A CA 002198557A CA 2198557 A CA2198557 A CA 2198557A CA 2198557 C CA2198557 C CA 2198557C
Authority
CA
Canada
Prior art keywords
gas
nitric oxide
oxygen
adsorbent
ammonia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002198557A
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English (en)
French (fr)
Other versions
CA2198557A1 (en
Inventor
Lien-Lung Sheu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Hospital Products IP Unlimited Co
Original Assignee
AGA AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AGA AB filed Critical AGA AB
Publication of CA2198557A1 publication Critical patent/CA2198557A1/en
Application granted granted Critical
Publication of CA2198557C publication Critical patent/CA2198557C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B21/00Nitrogen; Compounds thereof
    • C01B21/20Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
    • C01B21/24Nitric oxide (NO)
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B21/00Nitrogen; Compounds thereof
    • C01B21/20Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
    • C01B21/24Nitric oxide (NO)
    • C01B21/30Preparation by oxidation of nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10Preparation of respiratory gases or vapours
    • A61M16/12Preparation of respiratory gases or vapours by mixing different gases
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B21/00Nitrogen; Compounds thereof
    • C01B21/20Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
    • C01B21/24Nitric oxide (NO)
    • C01B21/26Preparation by catalytic or non-catalytic oxidation of ammonia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/02Gases
    • A61M2202/0266Nitrogen (N)
    • A61M2202/0275Nitric oxide [NO]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Separation Of Gases By Adsorption (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Drying Of Gases (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
CA002198557A 1996-04-02 1997-02-26 Method and apparatus for the production of nitric oxide gas mixture Expired - Lifetime CA2198557C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/626,413 US5692495A (en) 1996-04-02 1996-04-02 Method and apparatus for the production of nitric oxide gas mixture
US08/626,413 1996-04-02

Publications (2)

Publication Number Publication Date
CA2198557A1 CA2198557A1 (en) 1997-10-03
CA2198557C true CA2198557C (en) 2000-04-18

Family

ID=24510285

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002198557A Expired - Lifetime CA2198557C (en) 1996-04-02 1997-02-26 Method and apparatus for the production of nitric oxide gas mixture

Country Status (10)

Country Link
US (1) US5692495A (de)
EP (1) EP0799793B1 (de)
KR (1) KR100203721B1 (de)
AT (1) ATE244681T1 (de)
AU (1) AU710642B2 (de)
CA (1) CA2198557C (de)
DE (1) DE69723340T2 (de)
DK (1) DK0799793T3 (de)
ES (1) ES2205123T3 (de)
ZA (1) ZA972770B (de)

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US6758214B2 (en) 2000-01-28 2004-07-06 Cyterra Corporation Simple nitric oxide generator for ambulatory and/or bedside inhaled no treatment
US8066904B2 (en) * 2001-09-05 2011-11-29 Geno Llc Controlled generation of nitric oxide
US7618594B2 (en) 2004-08-18 2009-11-17 Geno Llc Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
WO2006023616A2 (en) * 2004-08-18 2006-03-02 Geno Llc Conversion of nitrogen dioxide (no2) to nitric oxide (no)
US20060048778A1 (en) * 2004-09-07 2006-03-09 Honeywell International, Inc. Low pressure-drop respirator filter
WO2008079993A2 (en) * 2006-12-22 2008-07-03 Ikaria, Inc. Combinations of nitric oxide and sulfide and methods of use and manufacture thereof
EP2131903B1 (de) 2007-03-23 2018-01-24 Geno LLC Umwandlung von stickstoffdioxid (no2) in stickoxid (no)
WO2008134490A1 (en) * 2007-04-26 2008-11-06 2B Technologies, Inc Method to produce a calibration, reagent or therapeutic gas by exposing a precursor gas to ultraviolet light
EP2247381B1 (de) * 2008-01-28 2016-11-30 Geno LLC Umwandlung von stickstoffdioxid (no2) in stickstoffmonoxid (no)
US8607785B2 (en) 2008-08-21 2013-12-17 Geno Llc Systems and devices for generating nitric oxide
US10780241B2 (en) * 2008-08-21 2020-09-22 Vero Biotech LLC Devices and methods for minimizing and treating high-altitude sickness
CN105214193B (zh) 2009-05-27 2017-11-17 马林克罗特医疗产品知识产权公司 用于药物递送调节装置的分度药物收容装置组件及分度药物递送系统
US8613958B2 (en) 2009-06-22 2013-12-24 Geno Llc Nitric oxide therapies
CA3130908A1 (en) 2009-06-30 2010-12-30 Mallinckrodt Hospital Products IP Limited Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension
CA2781295C (en) * 2009-11-20 2018-02-13 Geno Llc Nitric oxide delivery system
ES2873089T3 (es) * 2010-02-01 2021-11-03 Vero Biotech LLC Sistema de administración de óxido nítrico
FR2958638B1 (fr) * 2010-04-07 2012-04-27 Univ Littoral Cote D Opale Procede de fabrication d'oxyde d'azote (nxoy) et catalyseur pour la mise en oeuvre dudit procede
AU2011245476B2 (en) * 2010-04-26 2016-05-12 VERO Biotech LLC. Delivery of ultra pure nitric oxide (NO)
US8685467B2 (en) * 2010-08-03 2014-04-01 J. W. Randolph Miller Nitric oxide generation, dilution, and topical application apparatus and method
EP2619132B1 (de) * 2010-09-22 2019-04-17 Koninklijke Philips N.V. Verfahren zur herstellung von stickoxid
US20120107423A1 (en) 2010-11-01 2012-05-03 Ino Therapeutics Llc Methods of Using Inhaled Nitric Oxide Gas for Treatment of Acute Respiratory Distress Syndrome
EP3650408A1 (de) 2011-10-03 2020-05-13 NitricGen, Inc. Vorrichtung und verfahren zur erzeugung von stickoxid in kontrollierten und genauen mengen
BR112015022466B1 (pt) 2013-03-15 2022-11-08 The General Hospital Corporation Método e aparelho para síntese inspiratória de óxido nítrico
AU2014228152B2 (en) 2013-03-15 2018-07-05 The General Hospital Corporation Synthesis of nitric oxide gas for inhalation
US10517817B2 (en) 2013-05-09 2019-12-31 Syk Technologies, Llc Deep topical systemic nitric oxide therapy apparatus and method
KR101540383B1 (ko) 2014-03-19 2015-08-06 대성산업가스 주식회사 활성이 저하된 촉매를 이용한 일산화질소 제조장치 및 제조방법
EP3209359B1 (de) * 2014-10-20 2020-07-01 The General Hospital Corporation Systeme und verfahren zur synthese von stickoxid
WO2017132275A1 (en) 2016-01-27 2017-08-03 Syk Technologies, Llc Nitric oxide topical application apparatus and methods
BR112018069582A2 (pt) 2016-03-25 2019-01-22 Massachusetts Gen Hospital sistemas e métodos de entrega para síntese elétrica de plasma de óxido nítrico
CA3019140C (en) * 2016-04-04 2022-02-15 Jean-Philippe Trembley Indirectly cooled cryotherapy apparatus
CA3054656A1 (en) 2017-02-27 2018-08-30 Third Pole, Inc. Systems and methods for generating nitric oxide
CN110770163B (zh) 2017-02-27 2021-08-31 第三极股份有限公司 用于移动生成一氧化氮的系统和方法
MX2020010523A (es) 2017-02-27 2021-02-09 Third Pole Inc Sistemas y metodos para generar oxido nitrico.
WO2018183811A1 (en) 2017-03-31 2018-10-04 The General Hospital Corporation Systems and methods for a cooled nitric oxide generator
JP2022532654A (ja) 2019-05-15 2022-07-15 サード ポール,インコーポレイテッド 一酸化窒素を生成するシステム及び方法
JP2022533628A (ja) 2019-05-15 2022-07-25 サード ポール,インコーポレイテッド 一酸化窒素生成用電極
EP3969016A4 (de) 2019-05-15 2023-08-16 Third Pole, Inc. Architekturen zur herstellung von stickoxid
EP4069069A4 (de) 2020-01-11 2024-07-03 Third Pole, Inc. Systeme und verfahren zur stickoxid-erzeugung mit feuchtigkeitsregelung
WO2021252401A1 (en) * 2020-06-07 2021-12-16 Alti, Llc Nitric oxide generation, delivery, and monitoring system
US20210395905A1 (en) 2020-06-18 2021-12-23 Third Pole, Inc. Systems and methods for preventing and treating infections with nitric oxide
US12509349B2 (en) 2020-10-16 2025-12-30 Third Pole, Inc. Nitric oxide generation process controls
CN113636530A (zh) * 2021-07-22 2021-11-12 四川顺应动力电池材料有限公司 一种利用空气直接实现从氮气到硝酸一步转化的方法
EP4405019A4 (de) 2021-09-23 2025-07-16 Third Pole Inc Systeme und verfahren zur abgabe von stickoxid
CN114288504B (zh) * 2022-02-16 2024-03-22 山东世博金都药业有限公司 一种氢氧混合浓度可调节的氢氧呼吸机及其使用方法
WO2023201363A2 (en) 2022-04-14 2023-10-19 Third Pole, Inc. Delivery of medicinal gas in a liquid medium
KR102645395B1 (ko) 2022-12-20 2024-03-07 오남호 백금전극을 이용한 산화질소 발생장치
WO2025146689A1 (en) * 2024-01-04 2025-07-10 Ninox Medical Ltd. Method and system for delivering a breathable no-enriched gas mixture to a patient

Family Cites Families (11)

* Cited by examiner, † Cited by third party
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US2647822A (en) * 1948-04-13 1953-08-04 Robert D Pike Nitric oxide recovery system
US3660024A (en) * 1970-09-11 1972-05-02 Engelhard Min & Chem Process for ammonia oxidation
US3873675A (en) * 1971-09-14 1975-03-25 Degussa Catalyst and catalyst arrangement for the production of nitric acid
GB8516333D0 (en) * 1985-06-28 1985-07-31 Johnson Matthey Plc Nitric oxide
GB8630728D0 (en) * 1986-12-23 1987-02-04 Johnson Matthey Plc Ammonia oxidation catalyst pack
GB8901406D0 (en) * 1989-01-23 1989-03-15 Ici Plc Ammonia oxidation
US5396882A (en) * 1992-03-11 1995-03-14 The General Hospital Corporation Generation of nitric oxide from air for medical uses
US5558083A (en) * 1993-11-22 1996-09-24 Ohmeda Inc. Nitric oxide delivery system
EP0691154A1 (de) * 1994-07-07 1996-01-10 The Boc Group, Inc. Reinigung von Stickstoffmonoxid
US5514204A (en) * 1994-07-07 1996-05-07 The Boc Group, Inc. Process for the purification of nitric oxide
US5417950A (en) * 1994-07-07 1995-05-23 The Boc Group, Inc. Process for the purification of nitric oxide

Also Published As

Publication number Publication date
ATE244681T1 (de) 2003-07-15
US5692495A (en) 1997-12-02
AU710642B2 (en) 1999-09-23
ES2205123T3 (es) 2004-05-01
EP0799793A1 (de) 1997-10-08
KR970069875A (ko) 1997-11-07
DE69723340T2 (de) 2004-05-27
CA2198557A1 (en) 1997-10-03
DK0799793T3 (da) 2003-08-18
ZA972770B (en) 1997-10-24
AU1623997A (en) 1997-10-09
KR100203721B1 (ko) 1999-06-15
DE69723340D1 (de) 2003-08-14
EP0799793B1 (de) 2003-07-09

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Effective date: 20170227