CA2198557C - Method and apparatus for the production of nitric oxide gas mixture - Google Patents
Method and apparatus for the production of nitric oxide gas mixture Download PDFInfo
- Publication number
- CA2198557C CA2198557C CA002198557A CA2198557A CA2198557C CA 2198557 C CA2198557 C CA 2198557C CA 002198557 A CA002198557 A CA 002198557A CA 2198557 A CA2198557 A CA 2198557A CA 2198557 C CA2198557 C CA 2198557C
- Authority
- CA
- Canada
- Prior art keywords
- gas
- nitric oxide
- oxygen
- adsorbent
- ammonia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 137
- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 238000000034 method Methods 0.000 title claims description 18
- 238000004519 manufacturing process Methods 0.000 title description 6
- 239000007789 gas Substances 0.000 claims abstract description 99
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims abstract description 50
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 40
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 40
- 239000001301 oxygen Substances 0.000 claims abstract description 40
- 239000003463 adsorbent Substances 0.000 claims abstract description 33
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 claims abstract description 32
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229910021529 ammonia Inorganic materials 0.000 claims abstract description 24
- 239000003054 catalyst Substances 0.000 claims abstract description 19
- 229910000510 noble metal Inorganic materials 0.000 claims abstract description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 34
- 239000010457 zeolite Substances 0.000 claims description 27
- 229910021536 Zeolite Inorganic materials 0.000 claims description 17
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 17
- 229910052757 nitrogen Inorganic materials 0.000 claims description 17
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 10
- 230000002950 deficient Effects 0.000 claims description 9
- 238000001179 sorption measurement Methods 0.000 claims description 9
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 8
- 229910052782 aluminium Inorganic materials 0.000 claims description 7
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 7
- 229910002027 silica gel Inorganic materials 0.000 claims description 6
- 239000000741 silica gel Substances 0.000 claims description 6
- 230000003197 catalytic effect Effects 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 229910052763 palladium Inorganic materials 0.000 claims description 4
- 229910052697 platinum Inorganic materials 0.000 claims description 4
- 229910052703 rhodium Inorganic materials 0.000 claims description 4
- 239000010948 rhodium Substances 0.000 claims description 4
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 3
- 229910052741 iridium Inorganic materials 0.000 claims description 3
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 6
- 239000000376 reactant Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000002808 molecular sieve Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical class ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
- OLBVUFHMDRJKTK-UHFFFAOYSA-N [N].[O] Chemical compound [N].[O] OLBVUFHMDRJKTK-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910017604 nitric acid Inorganic materials 0.000 description 2
- 238000005201 scrubbing Methods 0.000 description 2
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 208000002330 Congenital Heart Defects Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010035742 Pneumonitis Diseases 0.000 description 1
- 229910001260 Pt alloy Inorganic materials 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- UNYSKUBLZGJSLV-UHFFFAOYSA-L calcium;1,3,5,2,4,6$l^{2}-trioxadisilaluminane 2,4-dioxide;dihydroxide;hexahydrate Chemical compound O.O.O.O.O.O.[OH-].[OH-].[Ca+2].O=[Si]1O[Al]O[Si](=O)O1.O=[Si]1O[Al]O[Si](=O)O1 UNYSKUBLZGJSLV-UHFFFAOYSA-L 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 229910052676 chabazite Inorganic materials 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 208000028831 congenital heart disease Diseases 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000010891 electric arc Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012013 faujasite Substances 0.000 description 1
- 239000008246 gaseous mixture Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229910052680 mordenite Inorganic materials 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 230000008695 pulmonary vasoconstriction Effects 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000012495 reaction gas Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- -1 types A Chemical class 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B21/00—Nitrogen; Compounds thereof
- C01B21/20—Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
- C01B21/24—Nitric oxide (NO)
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B21/00—Nitrogen; Compounds thereof
- C01B21/20—Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
- C01B21/24—Nitric oxide (NO)
- C01B21/30—Preparation by oxidation of nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B21/00—Nitrogen; Compounds thereof
- C01B21/20—Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
- C01B21/24—Nitric oxide (NO)
- C01B21/26—Preparation by catalytic or non-catalytic oxidation of ammonia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Separation Of Gases By Adsorption (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Drying Of Gases (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/626,413 US5692495A (en) | 1996-04-02 | 1996-04-02 | Method and apparatus for the production of nitric oxide gas mixture |
| US08/626,413 | 1996-04-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2198557A1 CA2198557A1 (en) | 1997-10-03 |
| CA2198557C true CA2198557C (en) | 2000-04-18 |
Family
ID=24510285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002198557A Expired - Lifetime CA2198557C (en) | 1996-04-02 | 1997-02-26 | Method and apparatus for the production of nitric oxide gas mixture |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5692495A (de) |
| EP (1) | EP0799793B1 (de) |
| KR (1) | KR100203721B1 (de) |
| AT (1) | ATE244681T1 (de) |
| AU (1) | AU710642B2 (de) |
| CA (1) | CA2198557C (de) |
| DE (1) | DE69723340T2 (de) |
| DK (1) | DK0799793T3 (de) |
| ES (1) | ES2205123T3 (de) |
| ZA (1) | ZA972770B (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6758214B2 (en) | 2000-01-28 | 2004-07-06 | Cyterra Corporation | Simple nitric oxide generator for ambulatory and/or bedside inhaled no treatment |
| US8066904B2 (en) * | 2001-09-05 | 2011-11-29 | Geno Llc | Controlled generation of nitric oxide |
| US7618594B2 (en) | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| WO2006023616A2 (en) * | 2004-08-18 | 2006-03-02 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| US20060048778A1 (en) * | 2004-09-07 | 2006-03-09 | Honeywell International, Inc. | Low pressure-drop respirator filter |
| WO2008079993A2 (en) * | 2006-12-22 | 2008-07-03 | Ikaria, Inc. | Combinations of nitric oxide and sulfide and methods of use and manufacture thereof |
| EP2131903B1 (de) | 2007-03-23 | 2018-01-24 | Geno LLC | Umwandlung von stickstoffdioxid (no2) in stickoxid (no) |
| WO2008134490A1 (en) * | 2007-04-26 | 2008-11-06 | 2B Technologies, Inc | Method to produce a calibration, reagent or therapeutic gas by exposing a precursor gas to ultraviolet light |
| EP2247381B1 (de) * | 2008-01-28 | 2016-11-30 | Geno LLC | Umwandlung von stickstoffdioxid (no2) in stickstoffmonoxid (no) |
| US8607785B2 (en) | 2008-08-21 | 2013-12-17 | Geno Llc | Systems and devices for generating nitric oxide |
| US10780241B2 (en) * | 2008-08-21 | 2020-09-22 | Vero Biotech LLC | Devices and methods for minimizing and treating high-altitude sickness |
| CN105214193B (zh) | 2009-05-27 | 2017-11-17 | 马林克罗特医疗产品知识产权公司 | 用于药物递送调节装置的分度药物收容装置组件及分度药物递送系统 |
| US8613958B2 (en) | 2009-06-22 | 2013-12-24 | Geno Llc | Nitric oxide therapies |
| CA3130908A1 (en) | 2009-06-30 | 2010-12-30 | Mallinckrodt Hospital Products IP Limited | Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension |
| CA2781295C (en) * | 2009-11-20 | 2018-02-13 | Geno Llc | Nitric oxide delivery system |
| ES2873089T3 (es) * | 2010-02-01 | 2021-11-03 | Vero Biotech LLC | Sistema de administración de óxido nítrico |
| FR2958638B1 (fr) * | 2010-04-07 | 2012-04-27 | Univ Littoral Cote D Opale | Procede de fabrication d'oxyde d'azote (nxoy) et catalyseur pour la mise en oeuvre dudit procede |
| AU2011245476B2 (en) * | 2010-04-26 | 2016-05-12 | VERO Biotech LLC. | Delivery of ultra pure nitric oxide (NO) |
| US8685467B2 (en) * | 2010-08-03 | 2014-04-01 | J. W. Randolph Miller | Nitric oxide generation, dilution, and topical application apparatus and method |
| EP2619132B1 (de) * | 2010-09-22 | 2019-04-17 | Koninklijke Philips N.V. | Verfahren zur herstellung von stickoxid |
| US20120107423A1 (en) | 2010-11-01 | 2012-05-03 | Ino Therapeutics Llc | Methods of Using Inhaled Nitric Oxide Gas for Treatment of Acute Respiratory Distress Syndrome |
| EP3650408A1 (de) | 2011-10-03 | 2020-05-13 | NitricGen, Inc. | Vorrichtung und verfahren zur erzeugung von stickoxid in kontrollierten und genauen mengen |
| BR112015022466B1 (pt) | 2013-03-15 | 2022-11-08 | The General Hospital Corporation | Método e aparelho para síntese inspiratória de óxido nítrico |
| AU2014228152B2 (en) | 2013-03-15 | 2018-07-05 | The General Hospital Corporation | Synthesis of nitric oxide gas for inhalation |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| KR101540383B1 (ko) | 2014-03-19 | 2015-08-06 | 대성산업가스 주식회사 | 활성이 저하된 촉매를 이용한 일산화질소 제조장치 및 제조방법 |
| EP3209359B1 (de) * | 2014-10-20 | 2020-07-01 | The General Hospital Corporation | Systeme und verfahren zur synthese von stickoxid |
| WO2017132275A1 (en) | 2016-01-27 | 2017-08-03 | Syk Technologies, Llc | Nitric oxide topical application apparatus and methods |
| BR112018069582A2 (pt) | 2016-03-25 | 2019-01-22 | Massachusetts Gen Hospital | sistemas e métodos de entrega para síntese elétrica de plasma de óxido nítrico |
| CA3019140C (en) * | 2016-04-04 | 2022-02-15 | Jean-Philippe Trembley | Indirectly cooled cryotherapy apparatus |
| CA3054656A1 (en) | 2017-02-27 | 2018-08-30 | Third Pole, Inc. | Systems and methods for generating nitric oxide |
| CN110770163B (zh) | 2017-02-27 | 2021-08-31 | 第三极股份有限公司 | 用于移动生成一氧化氮的系统和方法 |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| WO2018183811A1 (en) | 2017-03-31 | 2018-10-04 | The General Hospital Corporation | Systems and methods for a cooled nitric oxide generator |
| JP2022532654A (ja) | 2019-05-15 | 2022-07-15 | サード ポール,インコーポレイテッド | 一酸化窒素を生成するシステム及び方法 |
| JP2022533628A (ja) | 2019-05-15 | 2022-07-25 | サード ポール,インコーポレイテッド | 一酸化窒素生成用電極 |
| EP3969016A4 (de) | 2019-05-15 | 2023-08-16 | Third Pole, Inc. | Architekturen zur herstellung von stickoxid |
| EP4069069A4 (de) | 2020-01-11 | 2024-07-03 | Third Pole, Inc. | Systeme und verfahren zur stickoxid-erzeugung mit feuchtigkeitsregelung |
| WO2021252401A1 (en) * | 2020-06-07 | 2021-12-16 | Alti, Llc | Nitric oxide generation, delivery, and monitoring system |
| US20210395905A1 (en) | 2020-06-18 | 2021-12-23 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| US12509349B2 (en) | 2020-10-16 | 2025-12-30 | Third Pole, Inc. | Nitric oxide generation process controls |
| CN113636530A (zh) * | 2021-07-22 | 2021-11-12 | 四川顺应动力电池材料有限公司 | 一种利用空气直接实现从氮气到硝酸一步转化的方法 |
| EP4405019A4 (de) | 2021-09-23 | 2025-07-16 | Third Pole Inc | Systeme und verfahren zur abgabe von stickoxid |
| CN114288504B (zh) * | 2022-02-16 | 2024-03-22 | 山东世博金都药业有限公司 | 一种氢氧混合浓度可调节的氢氧呼吸机及其使用方法 |
| WO2023201363A2 (en) | 2022-04-14 | 2023-10-19 | Third Pole, Inc. | Delivery of medicinal gas in a liquid medium |
| KR102645395B1 (ko) | 2022-12-20 | 2024-03-07 | 오남호 | 백금전극을 이용한 산화질소 발생장치 |
| WO2025146689A1 (en) * | 2024-01-04 | 2025-07-10 | Ninox Medical Ltd. | Method and system for delivering a breathable no-enriched gas mixture to a patient |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2647822A (en) * | 1948-04-13 | 1953-08-04 | Robert D Pike | Nitric oxide recovery system |
| US3660024A (en) * | 1970-09-11 | 1972-05-02 | Engelhard Min & Chem | Process for ammonia oxidation |
| US3873675A (en) * | 1971-09-14 | 1975-03-25 | Degussa | Catalyst and catalyst arrangement for the production of nitric acid |
| GB8516333D0 (en) * | 1985-06-28 | 1985-07-31 | Johnson Matthey Plc | Nitric oxide |
| GB8630728D0 (en) * | 1986-12-23 | 1987-02-04 | Johnson Matthey Plc | Ammonia oxidation catalyst pack |
| GB8901406D0 (en) * | 1989-01-23 | 1989-03-15 | Ici Plc | Ammonia oxidation |
| US5396882A (en) * | 1992-03-11 | 1995-03-14 | The General Hospital Corporation | Generation of nitric oxide from air for medical uses |
| US5558083A (en) * | 1993-11-22 | 1996-09-24 | Ohmeda Inc. | Nitric oxide delivery system |
| EP0691154A1 (de) * | 1994-07-07 | 1996-01-10 | The Boc Group, Inc. | Reinigung von Stickstoffmonoxid |
| US5514204A (en) * | 1994-07-07 | 1996-05-07 | The Boc Group, Inc. | Process for the purification of nitric oxide |
| US5417950A (en) * | 1994-07-07 | 1995-05-23 | The Boc Group, Inc. | Process for the purification of nitric oxide |
-
1996
- 1996-04-02 US US08/626,413 patent/US5692495A/en not_active Expired - Lifetime
-
1997
- 1997-02-26 CA CA002198557A patent/CA2198557C/en not_active Expired - Lifetime
- 1997-03-11 AU AU16239/97A patent/AU710642B2/en not_active Expired
- 1997-03-27 DE DE69723340T patent/DE69723340T2/de not_active Expired - Lifetime
- 1997-03-27 EP EP97302198A patent/EP0799793B1/de not_active Expired - Lifetime
- 1997-03-27 AT AT97302198T patent/ATE244681T1/de active
- 1997-03-27 DK DK97302198T patent/DK0799793T3/da active
- 1997-03-27 ES ES97302198T patent/ES2205123T3/es not_active Expired - Lifetime
- 1997-04-01 KR KR1019970012047A patent/KR100203721B1/ko not_active Expired - Lifetime
- 1997-04-01 ZA ZA9702770A patent/ZA972770B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE244681T1 (de) | 2003-07-15 |
| US5692495A (en) | 1997-12-02 |
| AU710642B2 (en) | 1999-09-23 |
| ES2205123T3 (es) | 2004-05-01 |
| EP0799793A1 (de) | 1997-10-08 |
| KR970069875A (ko) | 1997-11-07 |
| DE69723340T2 (de) | 2004-05-27 |
| CA2198557A1 (en) | 1997-10-03 |
| DK0799793T3 (da) | 2003-08-18 |
| ZA972770B (en) | 1997-10-24 |
| AU1623997A (en) | 1997-10-09 |
| KR100203721B1 (ko) | 1999-06-15 |
| DE69723340D1 (de) | 2003-08-14 |
| EP0799793B1 (de) | 2003-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20170227 |