CA2201159A1 - Foie artificiel et son fonctionnement - Google Patents

Foie artificiel et son fonctionnement

Info

Publication number
CA2201159A1
CA2201159A1 CA002201159A CA2201159A CA2201159A1 CA 2201159 A1 CA2201159 A1 CA 2201159A1 CA 002201159 A CA002201159 A CA 002201159A CA 2201159 A CA2201159 A CA 2201159A CA 2201159 A1 CA2201159 A1 CA 2201159A1
Authority
CA
Canada
Prior art keywords
hepatocytes
biological fluid
culture medium
bioreactor
conduit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002201159A
Other languages
English (en)
Inventor
Edward F. Myers
Albert P. Li
Achilles Demetriou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
EXTEN INDUSTRIES Inc
Cedars Sinai Medical Center
Xenogenics Corp
Xenogenex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EXTEN INDUSTRIES Inc, Cedars Sinai Medical Center, Xenogenics Corp, Xenogenex Inc filed Critical EXTEN INDUSTRIES Inc
Priority to CA002201159A priority Critical patent/CA2201159A1/fr
Publication of CA2201159A1 publication Critical patent/CA2201159A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)

Abstract

Dispositifs constituant des foies artificiels permettant de purifier un fluide biologique et leur fonctionnement. Ce fonctionnement recouvre l'utilisation d'hépatocytes (23) vivants, fixés ou non à des porteurs inertes et en suspension dans un milieu de culture cellulaire s'écoulant avec les hépatocytes (23) dans ces dispositifs. Le sang ou le plasma passent d'un côté (7') de membranes semi-perméables, de l'autre côté (7) desquelles s'écoule un milieu de culture cellulaire et à travers lesquelles s'exerce un certain gradient de concentration et/ou de pression. Les solutés se diffusant à travers la membrane dans le milieu de culture cellulaire sont métabolisés par les hépatocytes (23) et/ou capturés par d'autres dispositifs complémentaires d'extraction (40). Les substances indésirables qui ne se diffusent pas hors du sang du plasma dans le milieu de culture contenant les hépatocytes sont capturées par des dispositifs complémentaires d'élimination (50).
CA002201159A 1994-09-27 1994-09-27 Foie artificiel et son fonctionnement Abandoned CA2201159A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002201159A CA2201159A1 (fr) 1994-09-27 1994-09-27 Foie artificiel et son fonctionnement

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002201159A CA2201159A1 (fr) 1994-09-27 1994-09-27 Foie artificiel et son fonctionnement

Publications (1)

Publication Number Publication Date
CA2201159A1 true CA2201159A1 (fr) 1996-04-04

Family

ID=4160267

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002201159A Abandoned CA2201159A1 (fr) 1994-09-27 1994-09-27 Foie artificiel et son fonctionnement

Country Status (1)

Country Link
CA (1) CA2201159A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022733A (en) * 1997-12-02 2000-02-08 Tam; Yun K. Simulated biological dissolution and absorption system
CN111979179A (zh) * 2020-08-24 2020-11-24 扬州大学 一种猪肝脏组织类器官模型及其体外构建方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022733A (en) * 1997-12-02 2000-02-08 Tam; Yun K. Simulated biological dissolution and absorption system
CN111979179A (zh) * 2020-08-24 2020-11-24 扬州大学 一种猪肝脏组织类器官模型及其体外构建方法
CN111979179B (zh) * 2020-08-24 2022-12-27 扬州大学 一种猪肝脏组织类器官模型及其体外构建方法

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued