CA2201750A1 - Complexe de chelates a perceptibilite elevee pour l'imagerie par resonance magnetique - Google Patents
Complexe de chelates a perceptibilite elevee pour l'imagerie par resonance magnetiqueInfo
- Publication number
- CA2201750A1 CA2201750A1 CA 2201750 CA2201750A CA2201750A1 CA 2201750 A1 CA2201750 A1 CA 2201750A1 CA 2201750 CA2201750 CA 2201750 CA 2201750 A CA2201750 A CA 2201750A CA 2201750 A1 CA2201750 A1 CA 2201750A1
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- CA
- Canada
- Prior art keywords
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- contrast
- agent
- signal intensity
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
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- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
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- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- KEAYESYHFKHZAL-IGMARMGPSA-N sodium-23 atom Chemical compound [23Na] KEAYESYHFKHZAL-IGMARMGPSA-N 0.000 description 1
- FGCSIJPPCNCQJB-FAOVPRGRSA-M sodium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;chloride Chemical compound [Na+].[Cl-].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O FGCSIJPPCNCQJB-FAOVPRGRSA-M 0.000 description 1
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- 230000009885 systemic effect Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 239000013008 thixotropic agent Substances 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 238000007487 urography Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
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- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- XLYOFNOQVPJJNP-OUBTZVSYSA-N water-17o Chemical compound [17OH2] XLYOFNOQVPJJNP-OUBTZVSYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
L'invention concerne des agents de contraste possédant des caractéristiques de contraste améliorées et destinés à être utilisés dans des techniques d'imagerie non limitées à l'imagerie par résonance magnétique. Elle concerne également des procédés de synthèse et d'administration des agents de contraste. De plus, elle concerne un nécessaire adapté à la vente dans le commerce.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31726794A | 1994-10-03 | 1994-10-03 | |
| US08/317,267 | 1994-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2201750A1 true CA2201750A1 (fr) | 1996-04-11 |
Family
ID=23232878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2201750 Abandoned CA2201750A1 (fr) | 1994-10-03 | 1995-10-03 | Complexe de chelates a perceptibilite elevee pour l'imagerie par resonance magnetique |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPH10509424A (fr) |
| AU (1) | AU3946395A (fr) |
| CA (1) | CA2201750A1 (fr) |
| WO (1) | WO1996010359A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8647604B2 (en) | 2006-01-25 | 2014-02-11 | Uvic Industry Partnerships Inc. | Lanthanide rich nanoparticles, and their investigative uses in MRI and related technologies |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000086538A (ja) * | 1998-09-17 | 2000-03-28 | Toshihiro Akaike | Ｍｒｉ用造影剤 |
| US7097826B2 (en) * | 1999-12-23 | 2006-08-29 | Health Research, Inc. | Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals |
| DE10325752A1 (de) * | 2003-06-06 | 2004-12-30 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Lektin-Konjugate |
| WO2005080032A1 (fr) * | 2004-02-20 | 2005-09-01 | Kazunori Kataoka | Procédé de fabrication de colloïde de fer, et micelle polymère porteuse de colloïde de fer |
| JP2010529090A (ja) * | 2007-06-08 | 2010-08-26 | ベルゲン・テクノロジオーヴァーフォリング・アクティーゼルスカブ | 常磁性生体分子複合体および器官機能の評価におけるその使用 |
| EP2327395A1 (fr) * | 2009-11-23 | 2011-06-01 | Bracco Imaging S.p.A | Procédé de préparation d'un complexe de gadobénate et de diméglumine sous forme solide |
| WO2012139030A1 (fr) * | 2011-04-06 | 2012-10-11 | Cedars-Sinai Medical Center | Nanoconjugués à base d'acide polymalique pour l'imagerie |
| US11896683B2 (en) | 2016-12-16 | 2024-02-13 | The Australian National University | Radiolabelled material for targeted administration |
| US20230158177A1 (en) * | 2021-11-19 | 2023-05-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Hypoxia-targeting contrast agent and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| JPH07110815B2 (ja) * | 1985-11-18 | 1995-11-29 | ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム | 画像及びスペクトル向上（およびスペクトルシフト）のためのポリキレ−ト剤 |
| US5057313A (en) * | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| DE3806795A1 (de) * | 1988-02-29 | 1989-09-07 | Schering Ag | Polymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5358702A (en) * | 1990-04-10 | 1994-10-25 | Unger Evan C | Methoxylated gel particle contrast media for improved diagnostic imaging |
-
1995
- 1995-10-03 AU AU39463/95A patent/AU3946395A/en not_active Abandoned
- 1995-10-03 JP JP8512116A patent/JPH10509424A/ja active Pending
- 1995-10-03 WO PCT/US1995/012693 patent/WO1996010359A1/fr not_active Ceased
- 1995-10-03 CA CA 2201750 patent/CA2201750A1/fr not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8647604B2 (en) | 2006-01-25 | 2014-02-11 | Uvic Industry Partnerships Inc. | Lanthanide rich nanoparticles, and their investigative uses in MRI and related technologies |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996010359A1 (fr) | 1996-04-11 |
| AU3946395A (en) | 1996-04-26 |
| JPH10509424A (ja) | 1998-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |