CA2205112C - Methode et composition de traitement de maladies mammaliennes provoquees par une reaction inflammatoire - Google Patents
Methode et composition de traitement de maladies mammaliennes provoquees par une reaction inflammatoire Download PDFInfo
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- CA2205112C CA2205112C CA002205112A CA2205112A CA2205112C CA 2205112 C CA2205112 C CA 2205112C CA 002205112 A CA002205112 A CA 002205112A CA 2205112 A CA2205112 A CA 2205112A CA 2205112 C CA2205112 C CA 2205112C
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- pyruvate
- respiratory disease
- inflammatory mediator
- pharmaceutical composition
- disease
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
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- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention porte sur une méthode de traitement d'un état pathologique chez des mammifères provoqué par des cellules mammaliennes impliquées dans une réaction inflammatoire. On met ces cellules mammaliennes participant à la réaction inflammatoire en contact avec un médiateur de la réaction inflammatoire, ce qui permet d'atténuer la réaction inflammatoire indésirable, ce médiateur étant un antioxydant. Ce médiateur de la réaction inflammatoire peut également fournir une source d'énergie cellulaire et constituer un bloc de construction dans la synthèse cellulaire d'autres composantes cellulaires. L'invention a également trait à des compositions visant à atténuer et à traiter une réaction inflammatoire indésirable.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US396295P | 1995-09-19 | 1995-09-19 | |
| US60/003,962 | 1995-09-19 | ||
| PCT/US1996/014304 WO1997010818A1 (fr) | 1995-09-19 | 1996-09-06 | Methode et composition de traitement de maladies mammaliennes provoquees par une reaction inflammatoire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2205112A1 CA2205112A1 (fr) | 1997-03-27 |
| CA2205112C true CA2205112C (fr) | 2008-11-18 |
Family
ID=21708422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002205112A Expired - Lifetime CA2205112C (fr) | 1995-09-19 | 1996-09-06 | Methode et composition de traitement de maladies mammaliennes provoquees par une reaction inflammatoire |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0804181A4 (fr) |
| JP (1) | JP4459303B2 (fr) |
| AU (1) | AU719332B2 (fr) |
| CA (1) | CA2205112C (fr) |
| IL (1) | IL119225A (fr) |
| MX (1) | MX9703653A (fr) |
| NZ (1) | NZ306832A (fr) |
| TW (1) | TW434012B (fr) |
| WO (1) | WO1997010818A1 (fr) |
| ZA (1) | ZA967833B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE493124T1 (de) * | 1999-05-14 | 2011-01-15 | Cellular Sciences Inc | Verfahren und zusammensetzung zur behandlung von entzündungsreaktion bedingten nasen- und nebenhölenkrankheiten in säugetieren |
| JP2004528307A (ja) * | 2001-03-15 | 2004-09-16 | ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | サイトカインにより媒介される炎症性状態の治療のためのピルベートおよび／またはその誘導体の使用方法 |
| US20030105162A1 (en) * | 2001-08-21 | 2003-06-05 | Celluar Sciences, Inc. | Method for treating bronchial constriction and bronchospasm |
| US6623723B2 (en) * | 2001-08-21 | 2003-09-23 | Cellular Sciences Inc. | Method for treating bronchial constriction and bronchospasm |
| US6689810B2 (en) * | 2001-08-21 | 2004-02-10 | Cellular Sciences, Inc. | Method for treating pulmonary disease states in mammals by altering indigenous in vivo levels of nitric oxide |
| US8076373B2 (en) * | 2001-09-11 | 2011-12-13 | North Cell Pharmacetical | Method for treating mammalian diseases and injuries caused by the over-expression of peroxynitrite |
| JP5630750B2 (ja) * | 2008-03-18 | 2014-11-26 | 国立大学法人 岡山大学 | 興奮性化学伝達調節剤およびそのスクリーニング法 |
| US11571455B2 (en) | 2013-04-11 | 2023-02-07 | Vanderbilt University | Methods and compositions for treating alcoholic liver disease |
| EP3638287A4 (fr) | 2017-06-16 | 2021-03-17 | Vanderbilt University | Méthodes et compositions pour le traitement d'une inflammation microbienne |
| EP3797766A1 (fr) * | 2019-09-24 | 2021-03-31 | Evonik Operations GmbH | Compositions à utiliser pour réduire l'inflammation |
| WO2021094341A1 (fr) * | 2019-11-14 | 2021-05-20 | Merck Patent Gmbh | Milieux de culture cellulaire |
| KR20240006050A (ko) * | 2021-05-04 | 2024-01-12 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 대사질환 치료를 위한 락토일 아미노산 |
| WO2023114375A2 (fr) * | 2021-12-16 | 2023-06-22 | Alveolus Bio, Inc. | Compositions d'acide lactique inhalables ou ingérables pour traitement d'une maladie pulmonaire chronique |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1857M (fr) * | 1962-03-08 | 1963-06-10 | Roussel Uclaf | Nouveau médicament notamment pour le traitement des maladies d'origine virale. |
| US3279997A (en) * | 1963-10-22 | 1966-10-18 | Herbert D Schneyer | Enteric coated calcium lactate tablets containing an antihistamine and thiamine chloride |
| US3879537A (en) * | 1973-09-04 | 1975-04-22 | Scott Eugene J Van | Treatment of ichthyosiform dermatoses |
| US3988470A (en) * | 1974-02-25 | 1976-10-26 | Scott Eugene J Van | Treatment of palmar and plant disturbed keratosis |
| US4158057A (en) * | 1975-03-28 | 1979-06-12 | Stanko Ronald T | Prevention of the accumulation of fatty deposits in the liver |
| US4021572A (en) * | 1975-07-23 | 1977-05-03 | Scott Eugene J Van | Prophylactic and therapeutic treatment of acne vulgaris utilizing lactamides and quaternary ammonium lactates |
| US4197316A (en) * | 1975-07-23 | 1980-04-08 | Scott Eugene J Van | Treatment of dry skin |
| US4234599A (en) * | 1978-10-04 | 1980-11-18 | Scott Eugene J Van | Treatment of skin keratoses with α-hydroxy acids and related compounds |
| US4415576A (en) * | 1981-04-01 | 1983-11-15 | Montefiore Hospital | Method for preventing body fat deposition in mammals |
| US4351835A (en) * | 1981-04-01 | 1982-09-28 | Montefiore Hospital | Method for preventing body fat deposition in mammals |
| US4521375A (en) * | 1982-11-23 | 1985-06-04 | Coopervision, Inc. | Sterilizing treatment with hydrogen peroxide and neutralization of residual amounts thereof |
| DE3302694A1 (de) * | 1983-01-27 | 1984-08-02 | Retheto Filmtechnik Theilemann & Co, 8000 München | Mundpflegemittel |
| US4663166A (en) * | 1984-06-22 | 1987-05-05 | Veech Richard L | Electrolyte solutions and in vivo use thereof |
| US4696917A (en) * | 1985-08-01 | 1987-09-29 | Lindstrom Richard L | Irrigation solution |
| JPS63135370A (ja) * | 1986-11-26 | 1988-06-07 | Grelan Pharmaceut Co Ltd | 抗アレルギ−剤 |
| IN168530B (fr) * | 1987-11-06 | 1991-04-20 | Lyphomed Inc | |
| AU4056089A (en) * | 1988-07-20 | 1990-02-19 | Amgen, Inc. | Method of treating inflammatory disorders by reducing phagocyte activation |
| JP2794021B2 (ja) * | 1988-11-02 | 1998-09-03 | エーザイ株式会社 | アゼラスチン或いはその塩類含有経皮適用製剤 |
| KR920700677A (ko) * | 1990-03-30 | 1992-08-10 | 스티븐 엠. 오드레 | 호흡기 파열 억제 인자 및 그의 제조방법과 그 인자를 이용한 상처, 염증성질환, 면역성 질환의 치료방법 및 제제 |
| US5210098A (en) * | 1990-09-21 | 1993-05-11 | Regents Of The University Of Minnesota | Use of pyruvate to treat acute renal failure |
| US5296370A (en) * | 1990-10-04 | 1994-03-22 | Rutgers, The State University | Repair medium for the resuscitation of injured cells |
| US5648380A (en) * | 1991-03-01 | 1997-07-15 | Warner-Lambert Company | Anti-inflammatory wound healing compositions and methods for preparing and using same |
| AU4275793A (en) * | 1992-02-25 | 1993-09-13 | Warner-Lambert Company | Cytoprotective compositions containing pyruvate and antioxidants |
| US5256697A (en) * | 1992-04-16 | 1993-10-26 | Abbott Laboratories | Method of administering pyruvate and methods of synthesizing pyruvate precursors |
| JP3236658B2 (ja) * | 1992-04-27 | 2001-12-10 | 花王株式会社 | 気管支拡張剤 |
| US5536751A (en) * | 1994-05-09 | 1996-07-16 | The United States Of America As Represented By The Secretary Of The Army | Pharmaceutical alpha-keto carboxylic acid compositions method of making and use thereof |
-
1996
- 1996-09-06 AU AU69159/96A patent/AU719332B2/en not_active Ceased
- 1996-09-06 EP EP96929932A patent/EP0804181A4/fr not_active Withdrawn
- 1996-09-06 CA CA002205112A patent/CA2205112C/fr not_active Expired - Lifetime
- 1996-09-06 MX MX9703653A patent/MX9703653A/es unknown
- 1996-09-06 NZ NZ306832A patent/NZ306832A/en not_active IP Right Cessation
- 1996-09-06 WO PCT/US1996/014304 patent/WO1997010818A1/fr not_active Ceased
- 1996-09-06 JP JP51274197A patent/JP4459303B2/ja not_active Expired - Lifetime
- 1996-09-09 IL IL11922596A patent/IL119225A/xx not_active IP Right Cessation
- 1996-09-17 ZA ZA967833A patent/ZA967833B/xx unknown
- 1996-09-18 TW TW085111379A patent/TW434012B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997010818A1 (fr) | 1997-03-27 |
| NZ306832A (en) | 2001-04-27 |
| IL119225A0 (en) | 1996-12-05 |
| AU6915996A (en) | 1997-04-09 |
| IL119225A (en) | 2000-09-28 |
| ZA967833B (en) | 1997-06-02 |
| MX9703653A (es) | 1998-07-31 |
| JP4459303B2 (ja) | 2010-04-28 |
| JPH10509463A (ja) | 1998-09-14 |
| AU719332B2 (en) | 2000-05-04 |
| EP0804181A4 (fr) | 2005-02-02 |
| TW434012B (en) | 2001-05-16 |
| EP0804181A1 (fr) | 1997-11-05 |
| CA2205112A1 (fr) | 1997-03-27 |
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| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20160906 |